Prevalence of Atherosclerotic Vascular Disease in Cuban Patients With Systemic Lupus Erythematosus
Prevalencia de enfermedad vascular aterosclerótica en pacientes cubanos con lupus eritematoso sistémico
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San Lázaro 701, Márquez González y Lucena. CP 10300. La Habana. Cuba." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia de enfermedad vascular aterosclerótica en pacientes cubanos con lupus eritematoso sistémico" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-03-08" "fechaAceptado" => "2007-10-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111702" "palabras" => array:3 [ 0 => "Prevalence" 1 => "Atherosclerotic vascular disease" 2 => "Systemic lupus erythematosus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111703" "palabras" => array:3 [ 0 => "Prevalencia" 1 => "Aterosclerosis vascular" 2 => "Lupus eritematoso sistémico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Atherosclerotic vascular disease-associated mortality and morbidity has increased in sick patients with systemic lupus erythematosus (SLE).</p> <span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine frequency of atherosclerotic vascular disease (AVD) in our patients, and to identify associations of some risk factors associated to its presence.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Study included 51 patients and 51 controls paired by age, sex, and skin colour, who underwent carotid ultrasound (US) to measure thickness of the intima-medial complex, and to determine presence of plaques. In patients and controls we analyzed the presence of classic risk factors, eg, age, smoking, high blood pressure, diabetes mellitus, and hyperlipidemia. In addition in SLE we also analyzed the influencie on AVD of the clinical features of disease, as well as treatments applied.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Risk factors were similar between patients and controls, except for hypertriglyceridemia, which was more frequent in patients. Presence of plaque was more prevalent in patients than in controls (59.9% vs 23.5%, <span class="elsevierStyleItalic">P</span>=.001). In multivariate analysis, age (OR, 1.31; 95% CI, 1.038–1.253; <span class="elsevierStyleItalic">P</span>=.005), diagnosis of SLE (OR, 3.872; 95% CI, 1.4–10.2; <span class="elsevierStyleItalic">P</span>=.005), and the presence of damage measured by SLICC/ACR (OR, 34.884; 95% CI, 1.1–12.9; <span class="elsevierStyleItalic">P</span>=.006) were the only variables independently associated to the presence of atherosclerosis in our patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Frequency of atherosclerosis is increased in patients presenting with SLE, risk factors independent of those classics, seem to be associated with this presence.</p>" ] "es" => array:1 [ "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La morbimortalidad asociada a enfermedad vascular aterosclerótica ha aumentado en los enfermos con lupus eritematoso sistémico (LES).</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar la frecuencia con que se encuentra la enfermedad vascular aterosclerótica en nuestros pacientes, e identificar la asociación de algunos factores de riesgo con su presencia.</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El estudio incluyó a 51 pacientes y 51 controles identificados por edad, sexo y color de piel, a quienes se realizó ultrasonido de carótida para medir el grosor del complejo íntima-media y determinar la presencia de placa. Se identificaron, en pacientes y controles, los factores de riesgos clásicos, como edad, hábito tabáquico, hipertensión arterial, diabetes mellitus e hiperlipemia. En los pacientes con LES se analizaron además las características clínicas de la enfermedad y los tratamientos recibidos. Finalmente, se estudió la influencia de todas estas variables en la enfermedad vascular aterosclerótica de los pacientes con LES.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Los factores de riesgo fueron similares entre pacientes y controles con la excepción de la hipertrigliceridemia más frecuente en los pacientes. La presencia de placa fue más prevalente en los pacientes que en los controles (el 56,9% frente al 23,5%, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001). En el análisis multivariable, la edad (<span class="elsevierStyleItalic">odds ratio</span> [OR]<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,31; intervalo de confianza [IC] del 95%, 1,038–1,253; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005), el diagnóstico de LES (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3,872; IC del 95%, 1,4–10,2; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005) y el daño sistémico valorado por el índice de SLICC/ACR (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3,884; IC del 95%, 1,1–12,9; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,006) fueron las variables que de forma independiente se asociaron a la presencia de aterosclerosis en los pacientes con LES.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La frecuencia de aterosclerosis se encuentra aumentada en los pacientes con LES, y parece que podría estar asociada a otros factores de riesgo independientes a los clásicamente implicados en la aterosclerosis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 21 | 31 | 52 |
| 2024 September | 35 | 27 | 62 |
| 2024 August | 32 | 52 | 84 |
| 2024 July | 26 | 37 | 63 |
| 2024 June | 34 | 37 | 71 |
| 2024 May | 28 | 31 | 59 |
| 2024 April | 21 | 19 | 40 |
| 2024 March | 26 | 27 | 53 |
| 2024 February | 20 | 31 | 51 |
| 2024 January | 19 | 19 | 38 |
| 2023 December | 13 | 31 | 44 |
| 2023 November | 25 | 27 | 52 |
| 2023 October | 33 | 34 | 67 |
| 2023 September | 46 | 37 | 83 |
| 2023 August | 19 | 16 | 35 |
| 2023 July | 21 | 28 | 49 |
| 2023 June | 29 | 22 | 51 |
| 2023 May | 23 | 14 | 37 |
| 2023 April | 12 | 10 | 22 |
| 2023 March | 17 | 21 | 38 |
| 2023 February | 15 | 29 | 44 |
| 2023 January | 18 | 20 | 38 |
| 2022 December | 16 | 31 | 47 |
| 2022 November | 28 | 22 | 50 |
| 2022 October | 15 | 27 | 42 |
| 2022 September | 18 | 34 | 52 |
| 2022 August | 16 | 42 | 58 |
| 2022 July | 18 | 45 | 63 |
| 2022 June | 15 | 38 | 53 |
| 2022 May | 18 | 40 | 58 |
| 2022 April | 26 | 58 | 84 |
| 2022 March | 23 | 48 | 71 |
| 2022 February | 22 | 25 | 47 |
| 2022 January | 16 | 44 | 60 |
| 2021 December | 16 | 39 | 55 |
| 2021 November | 23 | 45 | 68 |
| 2021 October | 25 | 48 | 73 |
| 2021 September | 34 | 40 | 74 |
| 2021 August | 18 | 36 | 54 |
| 2021 July | 18 | 36 | 54 |
| 2021 June | 22 | 32 | 54 |
| 2021 May | 20 | 28 | 48 |
| 2021 April | 26 | 37 | 63 |
| 2021 March | 35 | 15 | 50 |
| 2021 February | 47 | 29 | 76 |
| 2021 January | 29 | 22 | 51 |
| 2020 December | 19 | 16 | 35 |
| 2020 November | 18 | 22 | 40 |
| 2020 October | 8 | 8 | 16 |
| 2020 September | 26 | 15 | 41 |
| 2020 August | 17 | 15 | 32 |
| 2020 July | 20 | 21 | 41 |
| 2020 June | 22 | 18 | 40 |
| 2020 May | 14 | 12 | 26 |
| 2020 April | 21 | 19 | 40 |
| 2020 March | 18 | 13 | 31 |
| 2020 February | 3 | 0 | 3 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 1 | 0 | 1 |
| 2019 September | 4 | 0 | 4 |
| 2019 August | 2 | 0 | 2 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 4 | 0 | 4 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 3 | 0 | 3 |
| 2018 May | 4 | 2 | 6 |
| 2018 April | 21 | 9 | 30 |
| 2018 March | 14 | 10 | 24 |
| 2018 February | 10 | 2 | 12 |
| 2018 January | 9 | 6 | 15 |
| 2017 December | 8 | 5 | 13 |
| 2017 November | 10 | 5 | 15 |
| 2017 October | 16 | 5 | 21 |
| 2017 September | 10 | 2 | 12 |
| 2017 August | 9 | 5 | 14 |
| 2017 July | 7 | 8 | 15 |
| 2017 June | 26 | 16 | 42 |
| 2017 May | 25 | 6 | 31 |
| 2017 April | 11 | 5 | 16 |
| 2017 March | 10 | 14 | 24 |
| 2017 February | 8 | 2 | 10 |
| 2017 January | 18 | 3 | 21 |
| 2016 December | 38 | 13 | 51 |
| 2016 November | 16 | 4 | 20 |
| 2016 October | 24 | 8 | 32 |
| 2016 September | 23 | 7 | 30 |
| 2016 August | 24 | 3 | 27 |
| 2016 July | 14 | 5 | 19 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 1 | 0 | 1 |
| 2015 September | 3 | 0 | 3 |
| 2015 July | 12 | 5 | 17 |
| 2015 June | 17 | 11 | 28 |
| 2015 May | 18 | 15 | 33 |
| 2015 April | 19 | 16 | 35 |
| 2015 March | 16 | 4 | 20 |
| 2015 February | 13 | 8 | 21 |
| 2015 January | 14 | 9 | 23 |
| 2014 December | 16 | 7 | 23 |
| 2014 November | 14 | 6 | 20 |
| 2014 October | 16 | 10 | 26 |
| 2014 September | 11 | 8 | 19 |
| 2014 August | 15 | 13 | 28 |
| 2014 July | 18 | 9 | 27 |
| 2014 June | 34 | 7 | 41 |
| 2014 May | 24 | 11 | 35 |
| 2014 April | 33 | 9 | 42 |
| 2014 March | 35 | 18 | 53 |
| 2014 February | 24 | 5 | 29 |
| 2014 January | 28 | 8 | 36 |
| 2013 December | 24 | 7 | 31 |
| 2013 November | 21 | 10 | 31 |
| 2013 October | 30 | 12 | 42 |
| 2013 September | 25 | 9 | 34 |
| 2013 August | 21 | 5 | 26 |
| 2013 July | 19 | 6 | 25 |
| 2013 June | 21 | 6 | 27 |
| 2013 May | 11 | 6 | 17 |
| 2013 April | 20 | 3 | 23 |
| 2013 March | 14 | 9 | 23 |
| 2013 February | 26 | 6 | 32 |
| 2013 January | 12 | 8 | 20 |
| 2012 December | 15 | 7 | 22 |
| 2012 November | 6 | 2 | 8 |
| 2012 October | 8 | 4 | 12 |
| 2012 September | 9 | 4 | 13 |
| 2012 June | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 1 | 0 | 1 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 4 | 0 | 4 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 March | 6 | 0 | 6 |
| 2011 February | 14 | 0 | 14 |
| 2011 January | 12 | 0 | 12 |
| 2010 December | 2 | 0 | 2 |
| 2010 November | 4 | 0 | 4 |
| 2010 October | 7 | 0 | 7 |
| 2010 September | 4 | 0 | 4 |
| 2010 August | 6 | 0 | 6 |
| 2010 July | 7 | 0 | 7 |
| 2010 June | 1 | 0 | 1 |
| 2010 May | 10 | 0 | 10 |
| 2010 April | 10 | 0 | 10 |
| 2010 March | 3 | 0 | 3 |
| 2010 February | 2 | 0 | 2 |
| 2010 January | 3 | 0 | 3 |
| 2009 December | 19 | 0 | 19 |
| 2009 November | 10 | 0 | 10 |
| 2009 October | 7 | 0 | 7 |
| 2009 September | 7 | 0 | 7 |
| 2009 August | 6 | 0 | 6 |
| 2009 July | 3 | 0 | 3 |
| 2009 June | 13 | 0 | 13 |
| 2009 May | 7 | 0 | 7 |
| 2009 April | 12 | 0 | 12 |
| 2009 March | 7 | 0 | 7 |
Show all
