Publish in this journal
Journal Information
Vol. 12. Num. 1.January - February 2016
Pages 1-62
Download PDF
More article options
Vol. 12. Num. 1.January - February 2016
Pages 1-62
Special Article
DOI: 10.1016/j.reumae.2015.11.004
Non-celiac Gluten Sensitivity and Rheumatic Diseases
Sensibilidad al gluten no celíaca y enfermedades reumatológicas
Carlos Isasia,
Corresponding author

Corresponding author.
, Eva Tejerinab, Luz M. Moránc
a Servicio de Reumatología, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
c Servicio de Radiodiagnóstico, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
This item has received
Article information
Full Text
Download PDF
Figures (4)
Show moreShow less
Tables (2)
Table 1. Groups at Risk for Celiac Disease.
Table 2. Symptoms of Non-celiac Gluten Sensitivity.
Show moreShow less

Celiac disease is an autoimmune systemic disease having among its clinical manifestations frequent symptoms common to rheumatologic diseases such as musculoskeletal pain, asthenia, and cognitive fatigue. It is associated with other autoimmune diseases like Sjögren disease. It is a well-characterized disease with specific diagnostic tests.

Non-celiac gluten sensitivity is an emerging entity with symptoms similar to celiac disease, but without specific diagnostic tests. The concept of non-celiac gluten sensitivity and its diagnostic problems are reviewed, and the hypothesis of its association with fibromyalgia, spondyloarthritis, and autoimmune conditions is proposed. Clinical observations supporting the hypothesis are described, highlighting the benefit of treating non-celiac gluten sensitivity.

Celiac disease
Non-celiac gluten sensitivity

La enfermedad celíaca es una enfermedad autoinmune sistémica que tiene entre sus manifestaciones clínicas síntomas frecuentes en las enfermedades reumatológicas, como dolor musculoesquelético crónico, astenia y fatiga mental. Se asocia a otras enfermedades autoinmunes, como la enfermedad de Sjögren. Es una enfermedad bien caracterizada con pruebas diagnósticas específicas.

La sensibilidad al gluten no celíaca es una entidad emergente, con sintomatología similar a la de la enfermedad celíaca, pero sin pruebas diagnósticas específicas. Se revisan el concepto y los problemas diagnósticos de la sensibilidad al gluten no celíaca y se propone como hipótesis la asociación de la sensibilidad al gluten no celíaca a la fibromialgia, las espondiloartropatías y las enfermedades autoinmunes. Se describen observaciones clínicas que apoyan esta hipótesis, destacando el beneficio clínico del tratamiento de la sensibilidad al gluten.

Palabras clave:
Enfermedad celíaca
Sensibilidad al gluten no celíaca


These are the options to access the full texts of the publication Reumatología Clínica (English Edition)
If you are member of Sociedad Española de Reumatología (SER) or the Colegio Mexicano de Reumatología (CMR):
Please go to the member area of SER or CMR and log in.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Reumatología Clínica (English Edition)

From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
902 88 87 40
Calls from outside Spain
+34 932 418 800
Reumatología Clínica (English Edition)

Subscribe to our Newsletter

Article options
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.