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Vol. 12. Num. 1.January - February 2016
Pages 1-62
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Vol. 12. Num. 1.January - February 2016
Pages 1-62
Special Article
DOI: 10.1016/j.reumae.2015.11.004
Non-celiac Gluten Sensitivity and Rheumatic Diseases
Sensibilidad al gluten no celíaca y enfermedades reumatológicas
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Carlos Isasia,
Corresponding author
cisasi.hpth@salud.madrid.org

Corresponding author.
, Eva Tejerinab, Luz M. Moránc
a Servicio de Reumatología, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
c Servicio de Radiodiagnóstico, Hospital Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain
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Table 1. Groups at Risk for Celiac Disease.
Table 2. Symptoms of Non-celiac Gluten Sensitivity.
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Abstract

Celiac disease is an autoimmune systemic disease having among its clinical manifestations frequent symptoms common to rheumatologic diseases such as musculoskeletal pain, asthenia, and cognitive fatigue. It is associated with other autoimmune diseases like Sjögren disease. It is a well-characterized disease with specific diagnostic tests.

Non-celiac gluten sensitivity is an emerging entity with symptoms similar to celiac disease, but without specific diagnostic tests. The concept of non-celiac gluten sensitivity and its diagnostic problems are reviewed, and the hypothesis of its association with fibromyalgia, spondyloarthritis, and autoimmune conditions is proposed. Clinical observations supporting the hypothesis are described, highlighting the benefit of treating non-celiac gluten sensitivity.

Keywords:
Celiac disease
Non-celiac gluten sensitivity
Fibromyalgia
Spondyloarthritis
Autoimmunity
Resumen

La enfermedad celíaca es una enfermedad autoinmune sistémica que tiene entre sus manifestaciones clínicas síntomas frecuentes en las enfermedades reumatológicas, como dolor musculoesquelético crónico, astenia y fatiga mental. Se asocia a otras enfermedades autoinmunes, como la enfermedad de Sjögren. Es una enfermedad bien caracterizada con pruebas diagnósticas específicas.

La sensibilidad al gluten no celíaca es una entidad emergente, con sintomatología similar a la de la enfermedad celíaca, pero sin pruebas diagnósticas específicas. Se revisan el concepto y los problemas diagnósticos de la sensibilidad al gluten no celíaca y se propone como hipótesis la asociación de la sensibilidad al gluten no celíaca a la fibromialgia, las espondiloartropatías y las enfermedades autoinmunes. Se describen observaciones clínicas que apoyan esta hipótesis, destacando el beneficio clínico del tratamiento de la sensibilidad al gluten.

Palabras clave:
Enfermedad celíaca
Sensibilidad al gluten no celíaca
Fibromialgia
Espondiloartritis
Autoinmunidad

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