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Vol. 8. Num. 4.July - August 2012
Pages 163-232
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Vol. 8. Num. 4.July - August 2012
Pages 163-232
Continuing medical education
DOI: 10.1016/j.reumae.2011.06.006
Treatment of Paget's Disease of Bone
Tratamiento de la enfermedad ósea de Paget
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Leticia Lojo Oliveira??
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leticialojooliveira2@yahoo.es

Corresponding author.
, Antonio Torrijos Eslava
Unidad Metabólica Ósea, Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain
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Table 1. Classification of Bisphosphonates According to Their Amino Group.
Table 2. Bisphosphonate Doses Approved in Spain for PD.
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Abstract

Paget's disease of bone is the paradigm of bone focal distortion with accelerated bone turnover. Over the years, a number of different drugs have been used to control its activity but, since bisphosphonates were introduced for the treatment of the disease, they have become the preferred treatment. This review will update the therapeutic indications, available drugs and therapeutic response monitoring.

Keywords:
Paget's disease of bone
Osteitis deformans
Treatment
Bisphosphonates
Resumen

La enfermedad ósea de Paget es el paradigma de alteración focal esquelética con remodelado óseo acelerado. A lo largo de los años se han utilizado diferentes fármacos para el control de la actividad pero, desde la introducción de los bifosfonatos en la terapéutica de esta enfermedad, éstos se han convertido en el tratamiento de elección. A lo largo de esta revisión se abordarán de manera actualizada las indicaciones terapéuticas, los fármacos disponibles y la monitorización de la respuesta.

Palabras clave:
Enfermedad ósea de Paget
Osteítis deformante
Tratamiento
Bifosfonatos

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