Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Reumatol Clin 2012;8:220-4 - Vol. 8 Num.4 DOI: 10.1016/j.reumae.2011.06.006
Continuing medical education
Treatment of Paget's Disease of Bone
Tratamiento de la enfermedad ósea de Paget
Leticia Lojo Oliveira??, , Antonio Torrijos Eslava
Unidad Metabólica Ósea, Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain
Received 30 May 2011, Accepted 09 June 2011
Abstract

Paget's disease of bone is the paradigm of bone focal distortion with accelerated bone turnover. Over the years, a number of different drugs have been used to control its activity but, since bisphosphonates were introduced for the treatment of the disease, they have become the preferred treatment. This review will update the therapeutic indications, available drugs and therapeutic response monitoring.

Resumen

La enfermedad ósea de Paget es el paradigma de alteración focal esquelética con remodelado óseo acelerado. A lo largo de los años se han utilizado diferentes fármacos para el control de la actividad pero, desde la introducción de los bifosfonatos en la terapéutica de esta enfermedad, éstos se han convertido en el tratamiento de elección. A lo largo de esta revisión se abordarán de manera actualizada las indicaciones terapéuticas, los fármacos disponibles y la monitorización de la respuesta.

Keywords
Paget's disease of bone, Osteitis deformans, Treatment, Bisphosphonates
Palabras clave
Enfermedad ósea de Paget, Osteítis deformante, Tratamiento, Bifosfonatos

Article

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Reumatol Clin 2012;8:220-4 - Vol. 8 Num.4 DOI: 10.1016/j.reumae.2011.06.006
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