Reumatología Clínica (English Edition) Reumatología Clínica (English Edition)
Reumatol Clin 2017;13:294-6 - Vol. 13 Num.5 DOI: 10.1016/j.reumae.2017.04.001
Case Report
Relapsed Hydroxychloroquine Induced Thrombocytopenia in Systemic Lupus Erythematosus Patient
Trombocitopenia recurrente inducida por hidroxicloroquina en ausencia de actividad del lupus eritematoso sistémico
Vanesa Antón Vázqueza,, , Luis Pascuala, Héctor Corominas Maciasb, Isabel Giménez Torrecillac
a Servicio de Medicina Interna, Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain
b Servicio de Reumatología, Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain
c Servicio de Nefrología, Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain
Received 04 March 2016, Accepted 18 April 2016

Hydroxychloroquine is used in the long-term therapy of systemic lupus erythematosus (SLE). Although considered to be a safe treatment, side effects have been documented. An uncommon side effect is thrombocytopenia. In order to establish the diagnosis of thrombocytopenia secondary to Hydroxychloroquine, non-pharmacological causes must be ruled out and it is necessary to determine a recurrence after re-exposure to the drug. We present one case of severe thrombocytopenia occurring in a patient with SLE undergoing treatment with Hydroxychloroquine.


La hidroxicloroquina es un fármaco antimalárico, empleado como terapia a largo plazo en el lupus eritematoso sistémico (LES). A pesar de considerarse un tratamiento seguro, existen efectos adversos descritos. Uno muy infrecuente es la trombocitopenia. Para establecer el diagnóstico de trombocitopenia causada por hidroxicloroquina es necesario descartar otras causas no farmacológicas y objetivar la recurrencia tras la reexposición al fármaco. Presentamos un caso de trombocitopenia severa en un paciente con LES durante el tratamiento con hidroxicloroquina.

Hydroxychloroquine, Thrombocytopenia, Systemic lupus erythematosus
Palabras clave
Hidroxicloroquina, Trombocitopenia, Lupus eritematoso sistémico


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Reumatol Clin 2017;13:294-6 - Vol. 13 Num.5 DOI: 10.1016/j.reumae.2017.04.001
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