Reumatología Clínica Reumatología Clínica
Reumatol Clin 2008;4 Supl 1:17-21 - Vol. 4 DOI: 10.1016/S1699-258X(08)76134-5
Enfermedades sistémicas autoinmunitarias
Comorbilidad en lupus eritematoso sistémico
Comorbidity of Systemic Lupus Erythematosus
Eduardo Úcar Angulo, , Natalia Rivera García
Servicio de Reumatología. Hospital de Basurto. Bilbao. Vizcaya. España
Resumen

Los pacientes con lupus eritematoso sistémico (LES) padecen una serie de afecciones asociadas con mayor incidencia que en la población general. Esta comorbilidad incluye: infecciones, arteriosclerosis, arteriopatía coronaria, osteoporosis y necrosis avascular ósea, entre las más frecuentes. En general, estas complicaciones se relacionan, sobre todo, con el grado de actividad del LES y con las dosis de corticoides diarias y acumuladas. Se trata de resaltar la importancia que tiene esta comorbilidad para el pronóstico de nuestros pacientes y que debe estar presente a la hora de establecer el tratamiento en cada una de sus visitas.

Resumen

Patients with systemic lupus erythematosus (SLE) suffer a series of incidence-associated pathologies more frequent than general population. Comorbility includes: infections, arteriosclerosis, coronary arteriopathy, osteoporosis, and avascular necrosis of the bone, to name the more frequent ones. In general, such complications are related, above all, to the degree of SLE activity and the dosages of daily and accumulated corticoids. It is a matter of highlighting the importance of the associated pathologies in regards to our patients’ prognosis and of taking them into consideration when we establish a treatment for our patients’ during each one of their visits.

Palabras clave
Lupus, Comorbilidad, Infección, Arteriosclerosis, Osteoporosis
Key words
Lupus, Comorbility, Infection, Arteriosclerosis, Osteoporosis
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Bibliografía
1.
D.D. Gladman,M.B. Urowitz
Morbidity in systemic lupus erythematosus
2.
M. Petri,S. Perez-Gutthann,J.C. Longenecker,M.C. Hochberg
Morbidity of systemic lupus erythematosus: Role of race and socioeconomic status
3.
M. Petri,M. Genovese
Incidence of and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins Lupus Cohort
4.
F. Formiga Pérez,I. Moga Sampere,R. Canet González,M. Pac Ferraz,F. Mitjavila Villero,F. Fernández Nogués
Infection and systemic lupus erythematosus: analisis of a series of 145 patients
5.
F.J. Blanco,J.J. Gómez-Reino,J. De La Maza,A. Corrales,V. Rodriguez-Valverde,J.C. Rosas
Survival analysis of 306 European Spanish patients with systemic lupus erythematosus
6.
R. Cervera,M.A. Khamashta,J. Font,G.D. Sebastiani,A. Gil,P. Lavilla,A.O. Aydintug
Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1.000 patients. European Working Party on Systemic Lupus Erythematosus
7.
S. Rosner,E.M. Ginzler,H.S. Diamond,M. Weiner,M. Schlesinger,J.F. Fries
A multicenter study of outcome in systemic lupus erythematosus. II. Causes of death
8.
B. Holvast,A. Huckriede,C.G.M. Kallenberg,M. Bijl
Influenza vaccination in systemic lupus erythematosus: Safe and protective?
Autoimmun Rev, 6 (2007), pp. 300-305 http://dx.doi.org/10.1016/j.autrev.2006.09.012
9.
M.B. Urowitz,D. Ibáñez,D.D. Gladman
Atherosclerotic vascular events in a single large lupus cohort: Prevalence and risk factors
10.
M.M. Ward
Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus
11.
S. Manzi,F. Selzer,K. Sutton-Tyrrell,S.G. Fitzgerald,J.E. Rairie,R.P. Tracy
Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus
12.
K.H. Leona,E.T. Koh,P.H. Fena,M.L. Boey
Lipid profiles in patients with systemic lupus erythematosus
13.
D.J. Wallace,A.L. Metzger,V.J. Stecher,B.A. Turnbull,P.A. Kern
Colesterol lowering effect of hydroxychloroquine in patients with rheumatic disease: Effects on lipid metabolism
14.
E.F. Borba,E. Bonfa
Longterm beneficial effect of chloroquine diphosphate on lipoprotein profile in lupus patients with and without steroid therapy
15.
A. Abou-Raya,S. Abou-Raya
Inflammation: A pivotal link between autoimmune diseases and atherosclerosis
Autoimmun Rev, 5 (2006), pp. 331-337 http://dx.doi.org/10.1016/j.autrev.2005.12.006
16.
E. Krishnan
Stroke subtypes among young patients with systemic lupus erythematosus
17.
Y. Molad,N. Levin-Laina,M. Vaturi,J. Sulkes,A. Sagie
Herth valve calcification in young patients with systemic lupus erythematosus: A window to premature atherosclerotic vascular morbidity and risk factor for all-cause mortality
18.
B.F. Mandell
Cardiovascular involvement in systemic lupus erythematosus
19.
P.E. Lazzerini,P.L. Capecchi,F. Guideri,M. Acampa,M. Galeazzi,F. Laghi Pasini
Connective tissue diseases and cardiac rhythm disorders: An overview
Autoimmun Rev, 5 (2006), pp. 306-313 http://dx.doi.org/10.1016/j.autrev.2005.11.002
20.
M. Abu-Shraka,M.B. Urowitz,D.D. Gladman,J. Gough
Mortality studies in systemic lupus erythematosus. Results from a single centre. I. Causes of death
21.
D. Fen,R.W. Keen
Osteoporosis in systemic lupus erythematosus: Prevalence and therapy
22.
Y. Kipen,R. Buchbinder,A. Forbes,B. Strauss,G. Littlejohn,E. Morand
Prevalence of reduced bone mineral density in systemic lupus erythematosus and the role of steroids
23.
F. Formiga,I. Moga,J.M. Nolla,M. Pac,F. Mitjavila,D. Roig-Escofet
Loss of bone mineral density in premenopausal women with systemic lupus erythematosus
24.
R. Ramsey-Goldman,S. Mamzi
Association of osteoporosis and cardiovascular disease in women with systemic lupus erythematosus
25.
S.C. Manalagas,R. Jilka
Bone marrow, cytokines and bone remodeling. Emerging insights into the patophysiology of osteoporosis
26.
E.E. Velayos,J.D. Leidholt,C.J. Smyth,R. Priest
Arthropathy associated with steroid therapy
27.
P.L. Williams,M. Corbett
Avascular necrosis of bone complicating corticosteroid replacement therapy
28.
M. Petri
Musculoskeletal complications of systemic lupus erythematosus in the Hopkins Lupus Cohort: An update
29.
E.L. Dubois,L. Cozen
Avascular (aseptic) bone necrosis associated with systemic lupus erythematosus
30.
J.S. Sheik,G.S. Retzinger,H.V. Hess
Association of osteonecrosis in systemic lupus erythematosus with anormalities of fibrinolysis
31.
M.A. Mont,C.J. Glueck,I.H. Pacheco,P. Wang,D.S. Hungerford,M. Petri
Risk factors for osteonecrosis in systemic lupus erythematosus
32.
D.A. Blueinke,M. Petri,E.A. Zerhouni
Femoral head perfusion and composition: MR imaging and spectroscopic evaluation of patients with systemic lupus erythematosus and at risk for avascular necrosis
33.
G.S. Cooper,M.A. Dooley,E.L. Treadwell,E.W. St Clair,G.S. Gil Keson
Hormonal and reproductive risk factors for development of systemic lupus erythematosus: Results of a population-based, case-control study
Arthritis Rheum, 46 (2002), pp. 1830-1839 http://dx.doi.org/10.1002/art.10365
34.
A. Zonana-Nacach,S. Barr,L. Magder,M. Petri
Damage in SLE and its association with prednisone [resumen]
35.
S. Bernatsky,J. Boivin,J. Rajan,A. Zoma,S. Manzi,E. Ginzler
An international cohort study of cancer in systemic lupus erythematosus
Arthritis Rheum, 52 (2005), pp. 1481-1490 http://dx.doi.org/10.1002/art.21029
36.
J. Bin,S. Bernatsky,C. Gordon,J. Boivin,E. Ginzler,D. Gladman
Lung cancer in systemic lupus erythematosus
37.
L. Bjornadal,B. Lofstrom,L. Yin,I. Lundberg,A. Ekbom
Increased cancer incidence in a Swedish cohort of patients with systemic lupus erythematosus
38.
J. Cibere,J. Sibley,M. Haga
Systemic lupus erythematosus and the risk of malignancy
39.
J.F. Sequeiro,D. Cesic,G. Keser,M. Bukelica,S. Karanagnostis,M.A. Khamashtam
Allergic disorders in systemic lupus erythematosus
40.
S. Gaucha,S. Hamzaoui,M. Abdallam,K. Bouslama,A. Harmel,M. Ennafaa
Association lupus érythémateux systémique et psoriasis. À propos d’une observation
41.
F. Wolfe,H.A. Smythe,M.B. Yunus,R.M. Bennet,C. Bombardier,D.L. Goldenberg
The American College of Rheumatology 1990 criteria for the classification of fibromialgia: Report of the Multicentre Criteria Committee
42.
D.D. Gladman,M.B. Urowitz
Morbidity in systemic lupus erythematosus
43.
S. Manzi,E.N. Meilahn,J.E. Rairie,C. Conte,T.A. Medsger,L. Jansen-McWilliams
Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: Comparison with the Framingham Study
44.
M. Petri,S. Pérez-Gutthann,D. Spence,M.C. Hochberg
Risk factors for coronary artery disease in patients with systemic lupus erythematosus
45.
R. Cervera,on behalf of the members of the European Working Party on Systemic Lupus Erythematosus Systemic lupus erythematosus in Europe at the change of the millennium: Lessons from the “Euro-Lupus Proyect”
46.
S. Bernatsky,J.F. Boivin,L. Joseph,S. Manzi,E. Ginzler,D.D. Gladman
Mortality in systemic lupus erythematosus
Arthritis Rheum, 54 (2006), pp. 2550-2557 http://dx.doi.org/10.1002/art.21955
Correspondencia: Dr. E. Úcar Angulo. Servicio de Reumatología. Hospital de Basurto. Avda. Montevideo, 18. 48013 Bilbao. Vizcaya. España.
Copyright © 2008. Elsevier España S.L. Barcelona
Reumatol Clin 2008;4 Supl 1:17-21 - Vol. 4 DOI: 10.1016/S1699-258X(08)76134-5