Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis

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Original Article

Revisión sistemática y metaanálisis de la eficacia y la seguridad de leflunomida y metotrexato en el tratamiento de la artritis reumatoide

Roberto Alfaro-Laraa, Hector Fabricio Espinosa-Ortegab, César Alejandro Arce-Salinasc,

Corresponding author

, On behalf of the PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex

a Staff member, Hospital Central Sur Pemex, Mexico

b Assistant professor, Rheumatology consultant, Staff member, Hospital Central Sur Pemex, Mexico

c Professor and chairman, Division of Internal Medicine, Hospital Central Sur Pemex, Mexico

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Article information

ISSN: 1699258X
Original language: English

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Year/Month	Html	Pdf	Total

2025 6	7	23	30
2025 5	185	67	252
2025 4	191	59	250
2025 3	189	64	253
2025 2	170	59	229
2025 1	110	63	173
2024 12	150	51	201
2024 11	125	80	205
2024 10	145	62	207
2024 9	92	26	118
2024 8	102	52	154
2024 7	74	37	111
2024 6	105	60	165
2024 5	127	42	169
2024 4	165	66	231
2024 3	125	62	187
2024 2	126	71	197
2024 1	95	50	145
2023 12	89	49	138
2023 11	116	116	232
2023 10	118	49	167
2023 9	217	60	277
2023 8	208	45	253
2023 7	115	78	193
2023 6	128	52	180
2023 5	138	48	186
2023 4	126	45	171
2023 3	161	115	276
2023 2	95	47	142
2023 1	76	48	124
2022 12	168	95	263
2022 11	116	75	191
2022 10	171	82	253
2022 9	104	90	194
2022 8	99	103	202
2022 7	116	79	195
2022 6	143	74	217
2022 5	171	83	254
2022 4	214	82	296
2022 3	162	133	295
2022 2	124	76	200
2022 1	140	63	203
2021 12	129	73	202
2021 11	158	91	249
2021 10	106	83	189
2021 9	101	83	184
2021 8	62	67	129
2021 7	63	65	128
2021 6	90	67	157
2021 5	103	92	195
2021 4	468	218	686
2021 3	174	93	267
2021 2	184	45	229
2021 1	143	31	174
2020 12	147	48	195
2020 11	107	68	175
2020 10	77	49	126
2020 9	109	57	166
2020 8	143	52	195
2020 7	78	80	158
2020 6	85	42	127
2020 5	120	44	164
2020 4	134	62	196
2020 3	113	65	178
2020 2	107	69	176
2020 1	98	58	156
2019 12	105	55	160
2019 11	90	26	116
2019 10	8	9	17
2019 9	3	2	5
2019 8	4	4	8
2019 7	5	4	9
2019 6	5	4	9
2019 5	49	17	66
2019 4	107	62	169
2019 3	154	90	244
2019 2	68	37	105
2019 1	96	45	141
2018 12	82	58	140
2018 11	0	30	30
2018 10	0	23	23
2018 9	0	22	22
2018 8	0	19	19
2018 7	0	9	9
2018 5	0	7	7
2018 4	0	32	32
2018 3	0	54	54
2018 2	0	30	30
2018 1	0	35	35
2017 12	0	40	40
2017 11	0	67	67
2017 10	0	98	98
2017 9	0	158	158

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