TY - JOUR T1 - Mycophenolate mofetil in lupus nephritis refractary to intravenous cyclophosphamide JO - Reumatología Clínica (English Edition) T2 - AU - Daza,Leonel AU - Pérez,Salvador AU - Velasco,Ulises AU - Hernández,Martha SN - 21735743 UR - https://www.reumatologiaclinica.org/en-mycophenolate-mofetil-in-lupus-nephritis-articulo-13133692 AB - Objective: To evaluate the use of mycophenolate mofetil (MMF) in lupus nephritis (LN) patients with prior failure to intravenous cyclophosphamide over a 12-month follow-up. Patients and methods: Eleven patients with LN were included. MMF doses ranged from 1.5-2 grams per day. In all patients, 24-h urinary protein excretion, creatinine clearance, and serum creatinine were evaluated. Treatment-related adverse effects were recorded over the 12-month follow-up. Results: Basal proteinuria decreased from 1.63 g/L (95% CI: 0.78-2.5) to 0.93 (95% CI: 0.1-1.62) g/L at the end of the follow-up period (p = 0.04). Creatinine clearance showed a tendency to improve but no statistically significant differences were found, 69.2 (95% CI 51.4-87.4) vs. 79.29 (IC 95% 49.2-109.3) ml/min, respectively; p = 0.90). No significant differences were found in the remaining variables. Patients without response to MMF had a higher chronicity index than those with good or average response. Conclusion: MMF doses of 1.5-2 grams per day are a good alternative in LN patients without response to intravenous cyclophosphamide and a low chronicity index. No severe adverse effects were found. ER -