TY - JOUR T1 - Experience With the Use of Baricitinib and Tocilizumab Monotherapy or Combined, in Patients With Interstitial Pneumonia Secondary to Coronavirus COVID19: A Real-World Study JO - Reumatología Clínica (English Edition) T2 - AU - Rosas,José AU - Liaño,Francisco Pasquau AU - Cantó,Mónica Llombart AU - Barea,José María Carrasco AU - Beser,Amparo Raga AU - Rabasa,José Tomás Algado AU - Adsuar,Francisco Martínez AU - Auli,Brian Vila AU - López,Isabel Fernández AU - Sainz,Ana María Garijo AU - Ramis,Pere Esquerdo AU - Pérez,Laura Ruiz AU - Rebollo,Mª Luisa Navarrete AU - Lorido,Raquel Hernández AU - Escolar,Laura Gómez SN - 1699258X M3 - 10.1016/j.reuma.2020.10.009 DO - 10.1016/j.reuma.2020.10.009 UR - https://www.reumatologiaclinica.org/es-experience-with-use-baricitinib-tocilizumab-articulo-S1699258X20302710 AB - ObjectiveTo describe the experience of treatment with baricitinib (BARI) and/or tocilizumab (TCZ), in monotherapy or combined, in patients admitted for interstitial pneumonia secondary to COVID19, and for 30 days after discharge. MethodsMedical records of patients admitted with COVID19 and IP with PaO2/FiO2<300, treated with BARI and/or TCZ, and compared with patients who did not, were retrospectively reviewed. ResultsSixty patients were included; 43 (72%) are males, mean age 67 (SD: 14) years (<50 years: 17%; 51–70: 30%; >70: 53%), with 8.5 (SD: 1) days of symptoms. Sixteen (27%) patients required ICU (94% in <70 years). Fifteen (25%) patients died, 67% in >70 years; 11 (18%) patients died in the first 15 days of admission and 4 (7%) between days 16 to 30. Twenty-three (38%) patients received BARI, 12 (52%) monotherapy (Group 1), during 6 (SD: 2.6) days on average, none required ICU and 2 (17%) died. Thirty-one (52%) patients received TCZ, 20 (33%) as monotherapy (Group 2), 16 (52%) patients required ICU and 4 (20%) died. In the 11 (18%) patients who received BARI (2.8 [SD: 2.5] days average) and TCZ combined (Group 3), 3 (27%) required ICU and died. There were no severe side effects in BARI or TCZ patients. In the 17 (28%) patients who received neither BARI nor TCZ (Group 4), none required ICU and 6 (35%) died. Mean (SD) PaO2/FiO2 at admission between groups was respectively: 167 (82.3), 221 (114.9), 236 (82.3), 276 (83.2). ConclusionTreatment with BARI and TCZ did not cause serious side effects. They could be considered early in patients with NI secondary to COVID19 and impaired PaO2/PaFi. ER -