TY - JOUR T1 - McArdle Disease: 2 Case Reports JO - Reumatología Clínica (English Edition) T2 - AU - Diez Morrondo,Carolina AU - Pantoja Zarza,Lucía AU - San Millán Tejado,Beatriz SN - 21735743 M3 - 10.1016/j.reumae.2015.06.004 DO - 10.1016/j.reumae.2015.06.004 UR - https://www.reumatologiaclinica.org/en-mcardle-disease-2-case-reports-articulo-S2173574316000356 AB - A high serum level of creatine kinase (CK) is a common reason for referring to medical specialities. Myopathies are one of the causes of elevated levels of CK. McArdle disease is the most common disorder of skeletal muscle carbohydrate metabolism. The cases are presented on 2 patients who were referred to our medical consultation to study the cause of their increased CK levels: a 72-year-old asymptomatic man with high levels of CK detected by chance in a routine analysis, and a 30-year-old woman with very few symptoms, apart from slight muscle pain and tiredness. Electromyography was normal in both patients. There was null activity of myophosphorylase in muscle biopsy of both cases, so a diagnosis of McArdle disease was made. ER -