TY - JOUR T1 - Screening of interstitial lung disease in patients with rheumatoid arthritis: A systematic review JO - Reumatología Clínica (English Edition) T2 - AU - Garrote-Corral,Sandra AU - Silva-Fernández,Lucía AU - Seoane-Mato,Daniel AU - Guerra-Rodríguez,Mercedes AU - Aburto,Myriam AU - Castañeda,Santos AU - Valenzuela,Claudia AU - Narváez,Javier SN - 21735743 M3 - 10.1016/j.reumae.2021.07.002 DO - 10.1016/j.reumae.2021.07.002 UR - https://www.reumatologiaclinica.org/en-screening-interstitial-lung-disease-in-articulo-S2173574321001945 AB - AimsInterstitial lung disease (ILD) is frequent in patients with rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. The aim of this review was to identify the different screening methods for ILD in patients with RA. MethodsWe ran a systematic search in Pubmed, Embase and Cochrane Library up to April 2020 and did a hand search of the references of the retrieved articles. The search was limited to humans and articles published in English, Spanish or French. We selected studies with any design where: (a) the population included adult patients with RA; (b) the intervention was any screening method for ILD; and (c) validity or reliability of the screening method were evaluated, or a screening method was described. Two reviewers independently screened the articles by title and abstract and subsequently extracted the information using a specific data extraction form. Results25 studies were included with a total of 2593 patients. The most frequently used tool for ILD screening was high resolution computed tomography (HRCT) of the lung. Electronic auscultation, biochemical markers, bronchoalveolar lavage (BAL), pulmonary function tests (PFTs) and lung ultrasonography were also evaluated. Across the different studies, electronic auscultation and lung ultrasonography achieved higher accuracy than PFTs, BAL and biochemical markers. ConclusionsHRCT resulted as the most sensitive tool for ILD screening in patients with RA. Given its harmlessness and high sensitivity, lung ultrasonography may become the first-choice tool in the future. ER -