TY - JOUR T1 - Lack of association between periodontitis and rheumatoid arthritis JO - Reumatología Clínica (English Edition) T2 - AU - Posada-López,Adriana AU - Duque,Jose Daniel AU - Pineda-Tamayo,Ricardo Antonio AU - Bedoya-Giraldo,Emilio AU - Botero,Javier Enrique SN - 21735743 M3 - 10.1016/j.reumae.2022.03.006 DO - 10.1016/j.reumae.2022.03.006 UR - https://www.reumatologiaclinica.org/en-lack-association-between-periodontitis-rheumatoid-articulo-S217357432300014X AB - Background and objectivePeriodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials and methodsSeventy-five (75) participants distributed in 3 groups (21 patients with periodontitis without RA, 33 patients with periodontitis with RA and 21 patients with reduced periodontium with RA) were included in this cross-sectional study. A full periodontal and medical examination was performed in each patient. Additionally, subgingival plaque samples for the detection of Porphyromonas gingivalis (P. gingivalis) and blood samples for biochemical markers of RA were also taken. Logistic regression analysis adjusted for confounding variables, Spearman's rank correlation coefficient and a linear multivariate regression were used to analyze the data. ResultsPatients with RA presented less severity of periodontal parameters. The highest levels of anti-citrullinated protein antibodies were detected in non-periodontitis patients with RA. Covariates such as age, P. gingivalis, diabetes, smoking, osteoporosis and use of medication were not associated with RA. All periodontal variables and P. gingivalis expressed a negative correlation with biochemical markers of RA (P<0.05). ConclusionsPeriodontitis was not associated with RA. Furthermore, there was no correlation between periodontal clinical parameters and biochemical markers of RA. ER -