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Vol. 5. Issue 6.
Pages 280-284 (November - December 2009)
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Vol. 5. Issue 6.
Pages 280-284 (November - December 2009)
Review
DOI: 10.1016/S2173-5743(09)70136-4
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Fiftieth anniversary of the description of the chemical structure of antibodies
Cincuentenario del descubrimiento de la estructura química de los anticuerpos
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Dolores Ramos-Bello, Luis Llorente
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fluisllorentepeters57@gmail.com

Corresponding author.
Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, Mexico
Article information
Abstract

The identification of the antitoxic property of serum in 1890 by Emil von Behring and the introduction of the term “Antikörper” by Paul Ehrlich in 1891 referring to one of the most relevant mechanisms of defense of the adaptive immune system, ie, the humoral immune response mediators, mark the beginning of modern immunology. The “Y” structure was described 50 years ago by Gerald M. Edelman and Rodney R. Porter. Thus, on the fiftieth anniversary of the description of the chemical structure of antibodies, we consider it appropriate to celebrate this fact by sketching a brief outline and review of these epoch-making achievements.

Keywords:
Antibodies
History
Immunochemistry
Resumen

La identificación de la propiedad antitóxica del suero en 1890 por Emil von Behring y la introducción del término “Antikörper” por Paul Ehrlich en 1891 para referirse a uno de los mecanismos de defensa más relevantes del sistema inmunitario adaptativo, es decir, los mediadores de la respuesta inmunitaria humoral, marcan el inicio de la etapa de la inmunología moderna. La estructura en “Y” fue descrita hace cincuenta años por Gerald M. Edelman y Rodney R. Porter. Así, al cumplirse el cincuentenario de la descripción de la estructura química de los anticuerpos, consideramos oportuno no dejar pasar inadvertido el hecho a través de una breve remembranza y la revisión de dichos hallazgos.

Palabras clave:
Anticuerpos
Historia
Inmunoquímica
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