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Vol. 3. Issue 5.
Pages 237-240 (September - October 2007)
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Vol. 3. Issue 5.
Pages 237-240 (September - October 2007)
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Septic Arthritis Due to Bacteroides fragilis in a Patient With Non-Hodgkins Lymphoma and Mixed Connective Tissue Disease
Artritis séptica por Bacteroides fragilis en paciente con linfoma no hodgkiniano y enfermedad mixta del tejido conectivo
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Mario Luis Cousseaua,
Corresponding author
mlcousseau@yahoo.com.ar

Correspondence: Policlínica Privada Paz. 7000 Tandil. Buenos Aires. Argentina.
, Jorge Gentileb, Roxana Pérezc
a Servicio de Reumatología, Policlínica Privada Paz, Tandil, Buenos Aires, Argentina
b Servicio de Infectología, Sanatorio Tandil, Tandil, Buenos Aires, Argentina
c Laboratorio de Bioquímica, Sanatorio Tandil, Tandil, Buenos Aires, Argentina
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We present a 53 year old woman with pre-existing mixed collagen tissue disease who developed highlymalignant non-Hodgkin lymphoma and 2 years later had left groin abscess, then septic tenosynovitis of the left ankle, septic arthritis of the right shoulder, and purulent tenosynovitis of the right hand. Bacteroides fragilis was identified in synovial fluid drawn from the right shoulder, in blood cultures and in culture of a central venous catheter tip. The primary infection site is presumed to have been the abdominal cavity, and the presence of an indwelling central venous catheter the reason for recurrence of infection. We treated her empirically with intravenous ampicillin/sulbactam and clindamycine then oral metronidazole until definite resolution of the infection. Septic arthritis due to Bacteroides fragilis is a rare entity mainly occurring in immunocompromised patients, as shown in this case.

Key words:
Septic arthritis
Bacteroides fragilis
Non-Hodgkin lymphoma

Presentamos una paciente de 53 años de edad con enfermedad mixta del tejido conectivo que desarrolló un linfoma no hodgkiniano de alto grado de malignidad y 2 años más tarde, un cuadro de absceso inguinal izquierdo, luego tenosinovitis supurada de tobillo izquierdo y, finalmente, artritis séptica del hombro derecho y tenosinovitis supurada del tercer dedo de la mano derecha. Se logró aislar Bacteroides fragilis en líquido sinovial del hombro, en hemocultivos y en punta de catéter central intravenoso. El foco infeccioso primario se presume que haya sido intraabdominal, y el catéter central en permanencia, el factor de mantenimiento de la infección crónica. Utilizamos un tratamiento empírico secuencial de ampicilina/sulbactam y clindamicina intravenosos y más tarde metronidazol por vía oral hasta la cura definitiva de la infección. La artritis séptica por Bacteroides fragilis es una entidad rara que ocurre principalmente en pacientes inmunodeficientes, tal como refleja este caso.

Palabras clave:
Artritis séptica
Bacteroides fragilis
Linfoma no hodgkiniano
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