TY - JOUR T1 - Scleroderma renal crisis and ovarian hyperstimulation syndrome related to the use of clomiphene in a patient with scleroderma JO - Reumatología Clínica T2 - AU - Kobak,Şenol AU - Hacivelioglu,Servet AU - Gungor,Selen SN - 1699258X M3 - 10.1016/j.reuma.2012.11.003 DO - 10.1016/j.reuma.2012.11.003 UR - https://www.reumatologiaclinica.org/es-scleroderma-renal-crisis-ovarian-hyperstimulation-articulo-S1699258X13000223 AB - This paper presented a 28-year-old female with systemic sclerosis who developed scleroderma renal crisis and ovarian hyperstimulation syndrome following clomiphene administration. Urgent therapy including angiotensin-converting enzyme (ACE) inhibitors and supportive care resulted in regression and eventually resolution of all the clinical and laboratory symptoms. Although scleroderma renal crisis is a fatal complication of high-dose corticosteroids, rarely is this seen with the use of ACE inhibitors. This case report aimed to investigate the potential capacity of the selective oestrogen receptor modulator clomiphene to induce scleroderma renal crisis as well as corticosteroids. ER -