TY - JOUR T1 - How many patients with rheumatic diseases and TNF inhibitors treatment have latent tuberculosis? JO - Reumatología Clínica T2 - AU - Busquets-Pérez,Noemi AU - Ponce,Andrés AU - Ortiz-Santamaria,Vera AU - de Agustín de Oro,Juanjosé AU - Hernández-Rico,Yolanda León AU - Vidal,Imma AU - Alfonso,Carolina AU - Argemí,Sonia AU - Muñoz,Blanca AU - Quispe,Fernando AU - Díaz,Ana Carolina AU - Campos,Salvador AU - Hernández,Teresa Mariné AU - Torres,Miquel AU - Surís,Xavier SN - 1699258X M3 - 10.1016/j.reuma.2016.05.006 DO - 10.1016/j.reuma.2016.05.006 UR - https://www.reumatologiaclinica.org/es-how-many-patients-with-rheumatic-articulo-S1699258X1630050X AB - ObjectivesSpanish clinical guidelines recommend screening patients for tuberculosis (TB) before TNF inhibitors (TNFi) treatment. Our objective was to estimate the prevalence of TST seroconversion as an estimation of the prevalence of latent TB in patients with rheumatic diseases and TNFi treatment that have already been screened for tuberculosis. MethodsTST, booster and chest x-ray were performed to patients with rheumatic diseases, TNFi treatment, negative tuberculin skin tests before treatment and that were attending the rheumatology Department of three different hospitals in Barcelona. According to the Spanish Society Rheumatology guidelines, these patients had not received TB prophylaxis treatment. ResultsOne hundred and forty patients were included in the study. The tuberculin skin test was positive in 4.28% (n=6) of the patients. 50% of the patients were undergoing TNFi ≤ 2 years, being two of the patients only one year on the TNFi when a positive TST was detected. This shows that a conversion of the TST can occur even few months or years after the TNFi is started. ConclusionsThe present study observed that 4.28% of patients with rheumatic diseases on TNFi who did not have performed a pre-treatment TB prophylaxis, had a conversion of the TST. Moreover, the conversion of the TST had been within the first two years of treatment in half of the patients of our cohort. In spite of these results, false TST positives in the diagnosis of latent TB cannot be excluded as an explanation for our results. ER -