TY - JOUR T1 - Myositis-associated Interstitial Lung Disease: Clinical Characteristics and Factors Related to Pulmonary Function Improvement: A Latin-American Multicenter Cohort Study JO - Reumatología Clínica T2 - AU - Alberti,María Laura AU - Wolff,Verónica AU - Reyes,Felipe AU - Juárez-León,Ernesto AU - Fassola,Leandro AU - Carballo,Gabriel AU - Buendía-Roldán,Ivette AU - Rojas-Serrano,Jorge AU - Caro,Fabián AU - Florenzano,Matías AU - Paulín,Francisco SN - 1699258X M3 - 10.1016/j.reuma.2020.12.002 DO - 10.1016/j.reuma.2020.12.002 UR - https://www.reumatologiaclinica.org/es-myositis-associated-interstitial-lung-disease-clinical-articulo-S1699258X21000103 AB - Background and objectivesILD patients can be positive to highly specific autoantibodies of connective tissue diseases (CTD). Among them stand out myositis-specific and associated autoantibodies (MSA/MAA). There is limited knowledge about treatment response and prognosis of ILD patients positive to MSA/MAA (MSA/MAA-ILD). Our aim was to describe clinical, radiological and pulmonary function (PF) of MSA/MAA-ILD Latin-American patients and risk factors associated to PF at onset and long term follow up. MethodsMulticentric retrospective study of MSA/MAA-ILD patients evaluated between 2016 and 2018 in 3 ILD clinics in Latin America. Clinical, functional and tomographic variables were described. Variables associated with poor baseline PF and associated with functional improvement (FI) were analyzed in a multivariate logistic regression model. ResultsWe included 211 patients, 77.4% female, mean age 57 years old. Most frequent MSA/MAA were Ro-52 and Jo-1. Poor baseline PF was associated to ILD as initial diagnosis and NSIP/OP HRCT pattern. 121 patients were included in the follow up PF analysis: 48.8% remained stable and 33% had a significant FI. In multivariate analysis, OP pattern on HRCT was associated with FI. Systemic symptoms from the beginning and the absence of sclerodactyly showed a trend to be associated with FI. ConclusionsWorse baseline PF could be related to the absence of extra-thoracic symptoms and “classic” antibodies in CTD (ANA), which causes delay in diagnosis and treatment. In contrast, FI could be related to the presence of extra-thoracic signs that allow timely diagnosis and therapy, and more acute and subacute forms of ILD, such as OP pattern. ER -