CommentaryListeria meningitis in adults
References (10)
- CE Cherubin et al.
Listeria and gram-negative bacillary meningitis in New York City, 1972–1979. Frequent causes of meningitis in adults
Am J Med
(1981) - B Sigurdardottir et al.
Acute bacterial meningitis in adults. A 20-year overview
Arch Intern Med
(1997) - MI Durand et al.
Acute bacterial meningitis in adults: a review of 493 episodes
N Engl J Med
(1993) - JD Wenger et al.
Bacterial meningitis in the United State, 1986: report of a multistate surveillance study
J Inf Dis
(1990) - A Lavetter et al.
Meningitis due to Listeria monocytogenes: a review of 25 cases
N Engl J Med
(1971)
Cited by (20)
Central nervous system infection by Listeria monocytogenes in patients with systemic lupus erythematosus: Analysis of 26 cases, including the report of a new case
2013, Reumatologia ClinicaLas infecciones en pacientes con lupus eritematoso sistémico (LES) causan morbilidad significativa. La infección por Listeria monocytogenes (LM) se considera una enfermedad oportunista y ha sido publicada en raras ocasiones en pacientes con LES.
Revisar la forma de presentación de las infecciones por Listeria a nivel del sistema nervioso central (SNC) en pacientes con LES.
Se realizó una revisión bibliográfica, seleccionando los casos con cuadro de afección al sistema nervioso y confirmación de infección por L. monocytogenes en el cultivo.
Veintiséis casos son descritos. La forma de presentación más común fue la meningitis, siendo la meningoencefalitis y los abscesos cerebrales menos frecuentes. Los factores predisponentes son: empleo glucocorticoides, inmunosupresores, terapia de sustitución renal y el brote de actividad.
La infección del SNC por Listeria es poco común y, en ocasiones, fatal. La presentación atípica puede conducir a un retraso en el diagnóstico y el tratamiento adecuado. L. monocytogenes debe incluirse en el diagnóstico diferencial del paciente con LES y manifestaciones neurológicas.
Infections in patients with systemic lupus erythematosus cause significant morbidity. Infection due to Listeria monocytogenes (LM) is considered an opportunistic disease, and has been published on rare occasions in patients with SLE.
To review the presentation of listeria infections in the central nervous system (CNS) in SLE patients.
We conducted a literature review, selecting cases with central nervous system infection and confirmation of LM infection through culture.
Twenty six cases are described. The most common presentation was meningitis, with meningoencephalitis and brain abscesses being less frequent. The predisposing factors are: use of glucocorticoids, immunosuppressants, renal replacement therapy and the activity flares.
CNS infection by listeria is rare and sometimes fatal. The atypical presentation may lead to a delay in diagnosis and appropriate treatment. L. monocytogenes should be included in the differential diagnosis of patients with SLE with neurological manifestations.
Listeria Meningitis in a Patient with Regular Vital Diet and Proton Pump Inhibitor
2009, Tzu Chi Medical JournalListeria (L.) monocytogenes infection of the central nervous system is often seen in patients with underlying diseases or immunocompromised status. We report a 60-year-old immunocompetent woman who presented with progressively intermittent headache for 3 weeks. Brain magnetic resonance imaging revealed leptomeningeal enhancement on T1-weighted imaging. Cerebrospinal fluid culture showed L. monocytogenes. Dairy products containing yeast (which she has made daily at home for years) and undercooked vegetables (which she harvested and ate daily) may have been the sources of the L. monocytogenes infection. Therefore, we note that a diet of natural raw food may cause outbreaks or sporadic cases of listeriosis. The patient recovered completely after 6 weeks of treatment with ampicillin.
Perinatal Listeria monocytogenes infection during pregnancy and labour
2007, Progresos en Obstetricia y GinecologiaConocer la prevalencia de la infección perinatal por Listeria monocytogenes (LM) en nuestro centro y describir los efectos en el embarazo y el parto.
Se analizaron 21 casos de infección perinatal por LM que acontecieron en el Hospital Universitario Materno Infantil de Canarias entre los años 1992 y 2004. Los casos fueron localizados a través del registro de hemocultivos del servicio de medicina preventiva del hospital. Todos los casos presentaron, en la gestante o en el recién nacido, hemocultivos positivos frente a LM. Se evaluaron diferentes variables: la incidencia de la infección por LM durante ese período, la edad y paridad de las gestantes, la sintomatología, los resultados de las pruebas complementarias, el tratamiento realizado, el tipo y la vía del parto, las alteraciones en el registro cardiotocográfico (RCTG), las características del líquido amniótico y el estado del recién nacido (RN). El análisis se realizó de todos los casos con hemocultivo positivo frente a LM; se recogieron los resultados generales y, posteriormente, se los dividió en 2 grupos: en el grupo 1 se incluyó a las pacientes que presentaron un cuadro infeccioso en la gestación producto de la colonización por LM, diagnosticada por hemocultivo materno positivo, y en el grupo 2, a las gestantes que, con una gestación aparentemente normal, parieron un RN que presentó clínica de cuadro infeccioso y mostró hemocultivo positivo frente a LM.
La incidencia fue de 21 casos de infección diagnosticada por LM en 97.839 nacimientos (2,1 casos/10.000 nacimientos). Nueve gestantes fueron diagnosticadas de listeriosis por la presencia de clínica de cuadro infeccioso y hemocultivo materno positivo, y 12 neonatos fueron diagnosticados de listeriosis neonatal por la presencia de clínica de cuadro infeccioso y hemocultivo positivo. Seis (6/21) casos acabaron en aborto, 8 (8/21) casos en cesárea, 6 (6/21) partos fueron vaginales, 11 (11/21) RN fueron ingresados en la unidad de cuidados intensivos neonatales (UCIN), una (1/21) muerte se produjo durante el período neonatal, una gestación siguió en curso y 2 (2/21) RN sanos no requirieron ingreso (2/21).
To determine the prevalence of perinatal infection with Listeria monocytogenes in our center and to analyze the effects of this infection during pregnancy and labour.
Twenty-one cases of L. monocytogenes infection occurring in the University Maternity Hospital of the Canary Islands (Spain) between 1992 and 2004 were analyzed. Cases were identified through the blood culture registry of the hospital’s Preventive Medicine Service. Cases were defined as a positive blood culture to L. monocytogenes in pregnant women and/or their newborns. The following variables were evaluated: the incidence of L. monocytogenes infection during this period, age and parity of the pregnant women, symptoms, results of complementary investigations, treatment, type and route of delivery, alterations in cardiotocographic recording, amniotic fluid characteristics, and perinatal outcomes.
All cases with a positive blood culture to L. monocytogenes were analyzed. An overall analysis of the results was performed. Subsequently, the patients were divided into 2 groups: women with L. monocytogenes infection during pregnancy, diagnosed by positive maternal blood culture, and those with an apparently normal pregnancy whose neonates had a positive blood culture to L. monocytogenes.
The incidence was 21 cases of infection by L. monocytogenes diagnosed in our center out of 97,839 births (2.1 cases per 10,000 births). Nine women and 12 neonates were diagnosed with listeriosis on the basis of symptoms and a positive blood culture. Miscarriage occurred in 6 women (6/21), cesarian section was performed in 8 (8/21) and there were 6 vaginal deliveries (6/21). Eleven neonates (11/21) were admitted to the neonatal intensive care unit, one neonate died (1/21), one pregnancy was still in course, and two healthy neonates did not require admission to the neonatal intensive care unit (2/21).
The effect of centaurein on interferon-γ expression and Listeria infection in mice
2007, Toxicology and Applied PharmacologyWe previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
Listeriosis and pregnancy
2002, Clinica e Investigacion en Ginecologia y ObstetriciaLa listeriosis es una infección infrecuente. Se contagia a través de los alimentos infectados por la Listeria monocytogenes, que típicamente tiene predilección por mujeres gestantes, inmunodeprimidos, ancianos y niños. Teniendo gran variedad de manifestaciones clínicas, cuyas complicaciones para la madre y el feto son graves, pudiendo complicar un embarazo con abortos, muerte fetal anteparto, parto pretérmino y con listeriosis neonatal. En este artículo describimos un caso de listeriosis neonatal y una revisión de la bibliografía actual.
Listeriosis is an uncommon infection that has a unique predilection for pregnant women and may result in pregnancy loss. Contaminated food is the usual source of infection. It most often affects patients who are pregnant, at the extremes of life, or immunocompromised in some way. A variety of clinical manifestations are possible, but bacteremia and meningitis are most common. If Listeriachorioamnionitis is diagnosed preterm, in contrast to other types of chorioamnionitis, in utero therapy with high-dose penicillin or trimethoprim-sulfamethoxazole is possible, and preterm delivery may be avoided. The epidemiology, diagnosis, and management of Listeriainfection in pregnancy are reviewed.
Chemokines and chemotaxis of leukocytes in infectious meningitis
1998, Journal of NeuroimmunologyChemokines constitute a constantly growing family of small inflammatory cytokines. They have been implied in many different diseases of the CNS including trauma, stroke and inflammation, e.g., multiple sclerosis. In this review we focus on the role of chemokines in infectious meningitis of bacterial or viral origin. In experimental bacterial meningitis induced by Listeria monocytogeneses both CXC and CC chemokines namely MIP-1α, MIP-1β and MIP-2 are produced intrathecally by meningeal macrophages and leukocytes which infiltrate into the CNS. In patients with bacterial meningitis, IL-8, GROα, MCP-1, MIP-1α and MIP-1β are detectable in the CSF. These chemokines contribute to CSF mediated chemotaxis on neutrophils and PBMC in vitro. In viral meningitis IL-8, IP-10 and MCP-1 are identified in the CSF to be responsible for chemotactic activity on neutrophils, PBMC and activated T cells. Taken collectively these data indicate that the recruitment of leukocytes in infectious meningitis involves the intrathecal production of chemokines.