MiscellaneousValue of Neutrophil-Lymphocyte Ratio in Predicting Outcomes in Kawasaki Disease
Section snippets
Methods
This retrospective cohort study was approved by the institutional review board of Korea University Medical Center. The medical records of all consecutive patients with KD who were treated at the center from January 2008 to December 2013 were reviewed. KD was diagnosed when a patient exhibited ≥5 principal clinical manifestations, including fever >38°C. When the clinical manifestations did not fulfill the diagnostic criteria but other diagnoses could be excluded, incomplete KD was diagnosed if
Results
In the analysis of NLR as a predictor of IVIG resistance, 222 of 587 patients with KD were IVIG resistant (38%). Comparison of the IVIG-responsive and IVIG-resistant groups in terms of demographic and clinical variables (Table 1) revealed that the IVIG-resistant patients were more likely to be male, to be treated with IVIG earlier after the fever started, and to develop coronary dilatation or aneurysm. During the acute febrile phase, the 2 groups did not differ significantly in terms of total
Discussion
This study showed that IVIG-resistant patients had significantly higher NLRs in the acute febrile phase and 2 days after IVIG treatment than IVIG-responsive patients. Similarly, patients with CAAs and coronary aneurysms had higher NLRs than patients without CAAs during the acute febrile phase and particularly 2 days after IVIG. These observations indicate that the NLR can be used for risk stratification in patients with KD.
At the pathologic level, affected coronary arteries in patients with KD
Disclosures
The authors have no conflicts of interest to disclose.
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Cited by (0)
This study was supported by Grant K1132081 from Korea University, Seoul, Korea.
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