Original articlePretreatment antimüllerian hormone levels determine rate of posttherapy ovarian reserve recovery: acute changes in ovarian reserve during and after chemotherapy
Section snippets
Materials and methods
This study is part of a collaboration between the University of Pennsylvania (Penn), Children's Hospital of Philadelphia (CHOP), Children's Memorial Hospital in Chicago (CMH), and the University of North Carolina at Chapel Hill (UNC). Institutional review board approval was obtained at each site, and informed consent was obtained from all participants. The study included a visit before initiation of cancer therapy and then visits every 3 months from chemotherapy initiation. Study visits
Results
Eighty-one women between the ages of 15 and 35 years were enrolled in this study. Forty-six women had sufficient visits to be included in this report. Thirty eligible women were recruited from Penn, seven from CMH, six from CHOP, and three from UNC.
Baseline characteristics are presented in Table 1. Most participants were Caucasian, unmarried, normal weight, nulligravid, and college graduates. Nineteen (41%) of 46 participants were diagnosed with breast cancer and 37% with hematologic
Discussion
Cancer therapies have been shown to impair reproductive function in cancer survivors, but the acute impact of therapies on ovarian function in postpubertal adolescents and young women is not well documented. Future fertility is an important consideration for young women newly diagnosed with cancer, and better methods are needed to predict long-term reproductive potential in individual patients so that they can be counseled regarding fertility preservation strategies 12, 13.
Our study completed a
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2022, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :AMH recovery after gonadotoxic damage depends not only on the type of gonadotoxic agent but also the age and size of the ovarian reserve [23,26]. AMH values at the time of gonadotoxic treatment are also predictive of fertility recovery after gonadotoxic damage since there is a greater likelihood of menstrual cycle and fertility resumption with higher pretreatment AMH values [17,25]. AMH has also been investigated as a predictor of the impact of ovarian surgery on ovarian reserve, as in the case of ovarian endometriosis.
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K.E.D. has nothing to disclose. M.D.S. has nothing to disclose. M.P. has nothing to disclose. J.P.G. has nothing to disclose. D.W. has nothing to disclose. J.E.M. has nothing to disclose. Y.G. has nothing to disclose. C.R.G. has nothing to disclose.
Supported by NIH Grant K01 L:1-CA-133839–03 (CG); 1R01HD062797 (CG), and the Doris Duke Clinical Research Fellowship (KED).