CardiovascularMetabolic Syndrome and Cardiovascular Risk in Patients with Diffuse Idiopathic Skeletal Hyperostosis
Section snippets
Materials and Methods
Ninety-five consecutive patients attending our Rheumatic Diseases Unit were enrolled in the study. Forty-seven patients fulfilled the diagnostic criteria for DISH as suggested by Resnick and Niwayama (4), and 48 patients were diagnosed with OA without evidence of DISH. Patients were excluded from the study if they had a history of known angina pectoris, myocardial infarction, transient ischemic attacks, stroke, or peripheral vascular diseases. Data regarding demographics, smoking and medical
Results
The results revealed that patients with DISH had a significantly higher BMI and WC, while no significant differences were observed for age, sex distribution, serum total cholesterol, HDL, low-density lipoprotein, or TG levels (Table 1). Serum uric acid levels did not differ between the 2 groups. Significantly higher proportions of patients with DISH fulfilled the NCEP-MS parameters of WC, high blood pressure, and DM and were significantly more likely to meet the definition of NCEP-MS (Table 2).
Discussion
This study demonstrates that patients with DISH are significantly more likely to be affected by MS compared with age- and sex-matched patients without DISH. The 10-year CHD risk of patients with DISH is also significantly higher than the control group. The major contributors for the diagnosis of MS were high WC and HT for both NCEP-MS and WHO-MS, while hyperglycemia was a significant contributor only for NCEP-MS.
DISH is characterized by the production of coarse flowing osteophytes involving, in
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