MyositisInfectious Complications in Polymyositis and Dermatomyositis: A Series of 279 Patients
Section snippets
Patient Population
From 1996 to 2009, 279 consecutive patients with a diagnosis of PM (n = 148) and DM (n = 131) were included in the study. No patient had other connective tissue disorders. The criteria for diagnosis of PM/DM were based on the following from Bohan and Peter (12, 13): (1) symmetric muscle weakness; (2) increased serum muscle enzymes; (3) myopathic changes on electromyography; (4) typical histologic findings on muscle biopsy; and (5) characteristic dermatologic manifestations.
First, the medical
Results
The 279 PM/DM patients consisted of 110 men and 169 women with a median age of 52 years at diagnosis. The median duration of follow-up in our patients was 36 months [range: 1 to 264 months].
Discussion
Infections have been increasingly described in patients with connective-tissue diseases; Falagas and coworkers (14) have, in fact, reported the incidence of infections to be 8 to 77.5%, 4.5 to 55%, and 26 to 46%, respectively, in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Wegener's granulomatosis. Few authors have found the frequency of infections to be 25 to 33% in small series of PM/DM patients (1, 5, 8, 9, 10, 11). Our study is, to our knowledge, the
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The relationship between immunosuppressive therapy and clinical isolates for patients diagnosed with dermatomyositis-related interstitial lung diseases
2022, International ImmunopharmacologyCitation Excerpt :As the prominent side effect of intensive glucocorticoids in combination with long-term immunosuppressants used in DM-ILD, the occurrence of infection and/or microorganism colonization, is inevitable and will worsen the prognosis. According to previous reports, the leading cause of infection was aspiration pneumonia that was accounted for 16.7 ∼ 21.1 % of major infections in polymyositis (PM) and DM [15,16]. In the current study, we focused on discriminating the risk factors for infection/colonization in patients receiving immunosuppressive therapy, and found that DM-ILD patients complicated with infection or microbiological colonization have higher inflammatory biomarker and higher degree of fever, higher serum concentration of FK506, longer hospital stays and lower CD4+ T cell count than that of negative patients.
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