OsteoarthritisDiffuse Idiopathic Skeletal Hyperostosis and Its Relation to Back Pain Among Older Men: The MrOS Study
Section snippets
Parent Cohort
The MrOS Study enrolled 5995 men from March 2000 through April 2002 as described elsewhere (18, 19). Briefly, recruitment occurred at 6 US academic medical centers in Birmingham AL, Minneapolis MN, Palo Alto, CA, Pittsburgh PA, Portland OR, and San Diego, CA. Men aged 65 years and older who were able to walk unassisted and had at least 1 natural hip for femoral bone density measurement were eligible for the study. The MrOS study was approved by the Institutional Review Boards at all
Characteristics
Distributions of characteristics in the study sample and in the entire cohort were similar. For example, mean ± SD age was 74 ± 6 years in both the study sample and the parent cohort; mean height was 174 ± 7 cm in both, and the study sample mean for BMI was 28 ± 4, whereas the cohort mean BMI was 27 ± 4 (data not shown). The study sample participants were mainly white (90%); approximately 60% reported a history of smoking, and most reported their health as either excellent or good (85%).
Discussion
In this cohort of community-dwelling older men not preselected for back pain or medical reasons, DISH was present in 42%, with a nearly linear association between DISH prevalence and age. Measured systolic blood pressure, current BMI, and BMI at age 25 were also positively associated with DISH. Older men with DISH were also observed to be less likely to report a history of back pain in the past year than men without DISH.
Positive associations of DISH with age and BMI (6, 7, 15, 17, 26) and
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Cited by (0)
The Osteoporotic Fractures in Men (MrOS) Study is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), and the National Center for Research Resources (NCRR) and the NIH Roadmap for Medical Research through Grants U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01 AG027810, and UL1 RR024140.
The authors have no conflicts of interest to disclose.