Systemic lupus erythematosusNeuropsychiatric Lupus: The Prevalence and Autoantibody Associations Depend on the Definition: Results from the 1000 Faces of Lupus Cohort
Section snippets
Study Population
The 1000 Faces of Lupus Cohort (1000 Faces) is a prospective, multicenter cohort study of patients with a clinical diagnosis of SLE (meeting the ACR criteria). The goal of the cohort is to establish a long-term national lupus cohort to characterize lupus further in a contemporary Canadian context, particularly the effect of socioeconomic factors on disease activity, organ involvement, and outcomes. Recruitment began in July 2005 and included both incident and prevalent cases presenting at 14
Results
The 1000 Faces cohort consisted of 1417 patients, including 1253 adults and 164 children. Children were excluded from this analysis. The mean ± SD disease duration and age at study entry were 11.7 ± 10.2 and 41.0 ± 16.3 years, respectively. The majority was female (86%). Total numbers in the analyses vary, as some sites do not collect SLAM data. Subgroup size and characteristics were dependent on the specific definition of NPSLE. Adult patients were excluded from subgroup analysis if a required
Discussion
The 1000 Faces of Lupus cohort represents one of the largest lupus cohorts where NPSLE has been studied. NPSLE is a common manifestation in lupus and has been found to contribute significantly to morbidity, mortality, and quality of life (26, 27, 28, 29). Thus far, there has been little consensus in the published literature on the true prevalence of NP manifestations, despite the new ACR guidelines specifying diagnostic and exclusion criteria of 19 NP syndromes in 1999 (2). The largest barrier
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On behalf of the 1000 Faces of Lupus and Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus (CaNIOS).
This study was funded in part by a grant from the Arthritis Society of Canada.