Continuing medical education
Urinary sediment analysis
Análisis de sedimento urinario
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Mexico City, Mexico
Read
22678
Timeswas read the article
6193
Total PDF
16485
Total HTML
Share statistics
array:23 [ "pii" => "S2173574310700629" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70062-9" "estado" => "S300" "fechaPublicacion" => "2010-09-01" "aid" => "70062" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2010;6:268-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4893 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 1931 "PDF" => 2907 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574310700630" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70063-0" "estado" => "S300" "fechaPublicacion" => "2010-09-01" "aid" => "70063" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2010;6:273-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1767 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1126 "PDF" => 607 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in clinical rheumatology</span>" "titulo" => "Chronic back pain as the first symptom in the rupture of an abdominal aortic aneurism: presentation of 2 cases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "273" "paginaFinal" => "274" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lumbalgia crónica como primer síntoma en la rotura de aneurisma aórtico abdominal: a propósito de 2 casos clínicos" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rosalía Martínez Pérez, José Luis Marenco De La Fuente, Sergio Rodríguez Montero, Carmen Escudero" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Rosalía" "apellidos" => "Martínez Pérez" ] 1 => array:2 [ "nombre" => "José Luis Marenco" "apellidos" => "De La Fuente" ] 2 => array:2 [ "nombre" => "Sergio" "apellidos" => "Rodríguez Montero" ] 3 => array:2 [ "nombre" => "Carmen" "apellidos" => "Escudero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700630?idApp=UINPBA00004M" "url" => "/21735743/0000000600000005/v1_201305061612/S2173574310700630/v1_201305061612/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173574310700617" "issn" => "21735743" "doi" => "10.1016/S2173-5743(10)70061-7" "estado" => "S300" "fechaPublicacion" => "2010-09-01" "aid" => "70061" "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Reumatol Clin. 2010;6:264-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2278 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 1442 "PDF" => 785 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Utilization of hyperestrogenic therapies in systemic lupus erythematosus" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "264" "paginaFinal" => "267" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilización de terapias hiperestrogénicas en el lupus eritematoso sistémico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jaime Calvo-Alén, Cristina Mata, Elena Aurrecoechea" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Jaime" "apellidos" => "Calvo-Alén" ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "Mata" ] 2 => array:2 [ "nombre" => "Elena" "apellidos" => "Aurrecoechea" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700617?idApp=UINPBA00004M" "url" => "/21735743/0000000600000005/v1_201305061612/S2173574310700617/v1_201305061612/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Continuing medical education</span>" "titulo" => "Urinary sediment analysis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "268" "paginaFinal" => "272" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Martha E. Baños-Laredo, Carlos A. Núñez-Álvarez, Javier Cabiedes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Martha E." "apellidos" => "Baños-Laredo" ] 1 => array:4 [ "nombre" => "Carlos A." "apellidos" => "Núñez-Álvarez" "email" => array:1 [ 0 => "nuac80df@yahoo.com.mx" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Javier" "apellidos" => "Cabiedes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "fn1" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Mexico City, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de sedimento urinario" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-02-18" "fechaAceptado" => "2010-03-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112544" "palabras" => array:3 [ 0 => "Urinary sediment (US)" 1 => "Systemic lupus erythematosus (SLE)" 2 => "Lupus nephritis (LN)" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112545" "palabras" => array:3 [ 0 => "Sedimento urinario (SU)" 1 => "Lupus eritematoso generalizado (LEG)" 2 => "Nefritis lúpica (NL)" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Urinary analysis is one of the most requested tests in the clinical laboratory. This test includes the physical, chemical and microscopic analysis of urine. This last one allows for the observation of urinary sediment (US) in search of formed elements (cellular cast, leukocytes, etc.), with different diagnostic uses. Urinary analysis can be assessed by manual or automated methods. In the laboratory diagnosis of autoimmune diseases, US analysis is mainly oriented towards the assessment of renal function in patients with lupus nephritis (LN) as this is a common clinical manifestation associated to systemic lupus erythematosus (SLE). Additionally, its value lies mainly for diagnostic criteria and evaluation of kidney injury, as well as for several damage indexes directed to patients with SLE. In the last years, several groups have sought to establish new urinary biomarkers of kidney damage in patients with SLE; however, this requires a greater number of studies to determine their true diagnostic value in this patients group.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El examen general de orina es una de las pruebas más solicitadas dentro del laboratorio de análisis clínicos e incluye el análisis físico, químico y análisis microscópico. En este último, se analiza el sedimento urinario en búsqueda de distintos elementos formes (leucocitos, cilindros, etc.) con diferente utilidad diagnóstica. El análisis de sedimento urinario se puede valorar mediante métodos manuales y automatizados. En el diagnóstico por el laboratorio de las enfermedades autoinmunes el análisis de sedimento urinario está principalmente orientado hacia el apoyo y valoración renal en pacientes con nefritis lúpica, una de las manifestaciones clínicas más frecuentes en pacientes con lupus eritematoso generalizado. Adicionalmente, su utilidad radica fundamentalmente en su valoración en la mayoría de los criterios diagnósticos y de afección renal, así como en los diferentes índices de daño en pacientes con lupus eritematoso generalizado. En los últimos años, diversos grupos de investigación han buscado nuevos biomarcadores urinarios de afección renal en pacientes con lupus eritematoso generalizado, sin embargo se requiere un mayor número de estudios para determinar su verdadero valor diagnóstico en este grupo de pacientes.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Note: section acknowledged by SEAFORMEC with 1.7 credits. Please check questions from each article at: URL: <span class="elsevierStyleInterRef" href="http://www.reumatologiaclinica.org/">http://www.reumatologiaclinica.org</span>.</p>" ] 1 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">In memory of our teacher and friend</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A handbook of routine urinanalysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Graff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1983" "editorial" => "Lippincott" "editorialLocalizacion" => "Philadelphia" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Todd-Sanford clinical diagnosis by laboratory methods" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Davidsohn" 1 => "J. Bernard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "14 Ed" "fecha" => "1969" "editorial" => "WB Saunders Co." "editorialLocalizacion" => "Philadelphia" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 1982 revised criteria for the classification of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Tan" 1 => "A.S. Cohen" 2 => "J.F. Fries" 3 => "A.T. Masi" 4 => "D.J. McShane" 5 => "N.F. Rothfield" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1982" "volumen" => "25" "paginaInicial" => "1271" "paginaFinal" => "1277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7138600" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitative clinical assessment of disease activity in systemic lupus erythematosus: progress report and research agenda" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.H. Liang" 1 => "P.R. Fortin" 2 => "D.A. Isenberg" 3 => "L. Snaith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "1991" "volumen" => "11" "paginaInicial" => "133" "paginaFinal" => "136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1754816" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El sedimento urinario. Atlas, técnicas de estudio y valoración" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Althof" 1 => "J. Kindler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:2 [ "fecha" => "2003" "editorial" => "Ed. Médica Panamericana" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the Sysmex UF-100 automated urinalysis analyzer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Ben-Ezra" 1 => "L. Bork" 2 => "R.A. McPherson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1998" "volumen" => "44" "paginaInicial" => "92" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9550564" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitative urine particle analysis: integrative approach for the optimal combination of automation with UF-100 and microscopic review with KOVA cell chamber" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Ottiger" 1 => "A.R. Huber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "617" "paginaFinal" => "623" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12651815" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Automated flow cytometry compared with automated dipstick reader for urinalysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.R. Langlois" 1 => "J.R. Delangue" 2 => "S.R. Steyaert" 3 => "K.C. Everaert" 4 => "M.L. De Buyzere" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1999" "volumen" => "45" "paginaInicial" => "118" "paginaFinal" => "122" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9895347" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Instrucción operativa (IO-INM-63 V:0; Análisis de Sedimento Urinario). Laboratorio de Inmunología y Reumatología. Laboratorio Certificado ISO9001:2000 No. Cert: US04/3688." ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "National Committee for Clinical Laboratory Standards. Urinalysis and collection, transportation and preservation of urine specimens; urinalysis approved guideline. Clinical and Laboratory Standards Institute. 2009. Third Ed. Vol. 29 Number 4." ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the C-terminal structure of urinary Tamm-Horsfall protein reveals that the release of the glycosyl phosphatidylinositol-anchored counterpart from the kidney occurs by phenylalanine-specific proteolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Fukuoka" 1 => "K. Kobayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/bbrc.2001.6112" "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun" "fecha" => "2001" "volumen" => "289" "paginaInicial" => "1044" "paginaFinal" => "1048" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11741296" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of release of urinary Tamm-Horsfall glycoprotein from the kidney GPI-anchored counterpart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Cavallone" 1 => "N. Malagoni" 2 => "F. Serafini-Cessi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/bbrc.2000.4090" "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Commun" "fecha" => "2001" "volumen" => "280" "paginaInicial" => "110" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11162486" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tamm-Horsfall glycoprotein: biology and clinical relevance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Serafini-Cessi" 1 => "N. Malagolini" 2 => "D. Cavallone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "658" "paginaFinal" => "676" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14520616" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.C. Hochberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(199709)40:9<1725::AID-ART29>3.0.CO;2-Y" "Revista" => array:5 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1997" "volumen" => "40" "paginaInicial" => "1725" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9324033" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Derivation of the SLEDAI. A disease activity index for lupus patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Bombardier" 1 => "D. Gladman" 2 => "M.B. Urowitz" 3 => "D. Caron" 4 => "C.H.L. Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1992" "volumen" => "35" "paginaInicial" => "630" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1599520" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Guzmán" 1 => "M.H. Cardiel" 2 => "A. Arce-Salinas" 3 => "J. Sánchez-Guerrero" 4 => "D. Alarcón-Segovia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "1551" "paginaFinal" => "1558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1464867" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Hay" 1 => "P.A. Bacon" 2 => "C. Gordo" 3 => "D.A. Isenberg" 4 => "P. Maddison" 5 => "M.L. Snaith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Q J Med" "fecha" => "1993" "volumen" => "86" "paginaInicial" => "447" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8210301" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunological factors and clinical activity in lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.H. Schur" 1 => "J. Sandson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM196803072781004" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1968" "volumen" => "278" "paginaInicial" => "533" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4866347" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relation of immunoglobulin class, pattern of antinuclear antibody an complement fixing antibodies to DNA in sera from patients with systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.F. Rothfield" 1 => "B.D. Stollar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI105669" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "1967" "volumen" => "46" "paginaInicial" => "1785" "paginaFinal" => "1795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4168731" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal involvement in systemic lupus erythematosus (SLE): a study of 56 patients emphasizing histologic classification" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.B. Appel" 1 => "F.G. Silva" 2 => "C.L. Pirani" 3 => "J.I. Meltzer" 4 => "D. Estes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine" "fecha" => "1978" "volumen" => "57" "paginaInicial" => "371" "paginaFinal" => "410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/682942" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated urinary VCAM-1, P-Selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Wu" 1 => "C. Xie" 2 => "H.W. Wang" 3 => "X.J. Zhou" 4 => "N. Schwartz" 5 => "S. Calixto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2007" "volumen" => "179" "paginaInicial" => "7166" "paginaFinal" => "7175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17982109" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lipocalin-2, TWEAK and other cytokines as urinary biomarkers for lupus nephritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Schwartz" 1 => "J.S. Michaelson" 2 => "C. Putterman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1196/annals.1398.032" "Revista" => array:6 [ "tituloSerie" => "Ann NY Acad Sci" "fecha" => "2007" "volumen" => "1109" "paginaInicial" => "265" "paginaFinal" => "274" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17785315" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary biomarkers in lupus nephritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Li" 1 => "M. Tucci" 2 => "S. Narain" 3 => "E.V. Barnes" 4 => "E.S. Sobel" 5 => "M.S. Segal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2005.10.006" "Revista" => array:6 [ "tituloSerie" => "Autoimmun Rev" "fecha" => "2006" "volumen" => "5" "paginaInicial" => "383" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16890891" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Reyes-Thomas J, Blanco I, Putterman C. Urinary biomarkers in lupus nephritis. 2010 (2):Epub ahead of print." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000005/v1_201305061612/S2173574310700629/v1_201305061612/en/main.assets" "Apartado" => array:4 [ "identificador" => "8414" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Continuing Medical Education" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000005/v1_201305061612/S2173574310700629/v1_201305061612/en/main.pdf?idApp=UINPBA00004M&text.app=https://www.reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700629?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 319 | 44 | 363 |
| 2024 September | 512 | 43 | 555 |
| 2024 August | 542 | 55 | 597 |
| 2024 July | 599 | 82 | 681 |
| 2024 June | 466 | 48 | 514 |
| 2024 May | 499 | 54 | 553 |
| 2024 April | 423 | 45 | 468 |
| 2024 March | 449 | 69 | 518 |
| 2024 February | 411 | 43 | 454 |
| 2024 January | 737 | 52 | 789 |
| 2023 December | 503 | 38 | 541 |
| 2023 November | 554 | 79 | 633 |
| 2023 October | 724 | 71 | 795 |
| 2023 September | 440 | 68 | 508 |
| 2023 August | 355 | 37 | 392 |
| 2023 July | 300 | 41 | 341 |
| 2023 June | 250 | 35 | 285 |
| 2023 May | 254 | 37 | 291 |
| 2023 April | 269 | 25 | 294 |
| 2023 March | 331 | 57 | 388 |
| 2023 February | 261 | 65 | 326 |
| 2023 January | 264 | 60 | 324 |
| 2022 December | 225 | 92 | 317 |
| 2022 November | 351 | 67 | 418 |
| 2022 October | 246 | 47 | 293 |
| 2022 September | 235 | 66 | 301 |
| 2022 August | 226 | 57 | 283 |
| 2022 July | 169 | 70 | 239 |
| 2022 June | 183 | 89 | 272 |
| 2022 May | 227 | 128 | 355 |
| 2022 April | 201 | 243 | 444 |
| 2022 March | 210 | 108 | 318 |
| 2022 February | 160 | 83 | 243 |
| 2022 January | 201 | 83 | 284 |
| 2021 December | 173 | 78 | 251 |
| 2021 November | 178 | 73 | 251 |
| 2021 October | 283 | 78 | 361 |
| 2021 September | 115 | 55 | 170 |
| 2021 August | 315 | 76 | 391 |
| 2021 July | 91 | 51 | 142 |
| 2021 June | 111 | 63 | 174 |
| 2021 May | 130 | 32 | 162 |
| 2021 April | 192 | 105 | 297 |
| 2021 March | 152 | 35 | 187 |
| 2021 February | 102 | 36 | 138 |
| 2021 January | 94 | 32 | 126 |
| 2020 December | 80 | 21 | 101 |
| 2020 November | 79 | 34 | 113 |
| 2020 October | 39 | 33 | 72 |
| 2020 September | 62 | 31 | 93 |
| 2020 August | 42 | 27 | 69 |
| 2020 July | 44 | 33 | 77 |
| 2020 June | 68 | 43 | 111 |
| 2020 May | 54 | 34 | 88 |
| 2020 April | 32 | 27 | 59 |
| 2020 March | 22 | 8 | 30 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 5 | 2 | 7 |
| 2018 April | 30 | 20 | 50 |
| 2018 March | 32 | 19 | 51 |
| 2018 February | 13 | 12 | 25 |
| 2018 January | 17 | 6 | 23 |
| 2017 December | 25 | 15 | 40 |
| 2017 November | 20 | 24 | 44 |
| 2017 October | 21 | 22 | 43 |
| 2017 September | 24 | 19 | 43 |
| 2017 August | 19 | 32 | 51 |
| 2017 July | 20 | 23 | 43 |
| 2017 June | 45 | 32 | 77 |
| 2017 May | 46 | 23 | 69 |
| 2017 April | 22 | 21 | 43 |
| 2017 March | 24 | 35 | 59 |
| 2017 February | 24 | 19 | 43 |
| 2017 January | 19 | 15 | 34 |
| 2016 December | 45 | 21 | 66 |
| 2016 November | 35 | 15 | 50 |
| 2016 October | 31 | 16 | 47 |
| 2016 September | 35 | 15 | 50 |
| 2016 August | 35 | 21 | 56 |
| 2016 July | 16 | 10 | 26 |
| 2016 June | 0 | 13 | 13 |
| 2016 May | 0 | 16 | 16 |
| 2016 April | 1 | 14 | 15 |
| 2016 March | 2 | 12 | 14 |
| 2016 February | 3 | 9 | 12 |
| 2016 January | 2 | 16 | 18 |
| 2015 December | 6 | 0 | 6 |
| 2015 November | 1 | 10 | 11 |
| 2015 October | 1 | 16 | 17 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 3 | 0 | 3 |
| 2015 July | 29 | 6 | 35 |
| 2015 June | 30 | 119 | 149 |
| 2015 May | 54 | 166 | 220 |
| 2015 April | 42 | 179 | 221 |
| 2015 March | 50 | 168 | 218 |
| 2015 February | 30 | 151 | 181 |
| 2015 January | 34 | 136 | 170 |
| 2014 December | 37 | 139 | 176 |
| 2014 November | 31 | 159 | 190 |
| 2014 October | 28 | 157 | 185 |
| 2014 September | 33 | 128 | 161 |
| 2014 August | 41 | 90 | 131 |
| 2014 July | 38 | 62 | 100 |
| 2014 June | 54 | 61 | 115 |
| 2014 May | 52 | 53 | 105 |
| 2014 April | 48 | 47 | 95 |
| 2014 March | 33 | 56 | 89 |
| 2014 February | 29 | 32 | 61 |
| 2014 January | 28 | 40 | 68 |
| 2013 December | 32 | 24 | 56 |
| 2013 November | 42 | 33 | 75 |
| 2013 October | 34 | 31 | 65 |
| 2013 September | 37 | 31 | 68 |
| 2013 August | 59 | 55 | 114 |
| 2013 July | 38 | 23 | 61 |
| 2013 June | 50 | 28 | 78 |
| 2013 May | 48 | 26 | 74 |
| 2013 April | 34 | 18 | 52 |
| 2013 March | 33 | 36 | 69 |
| 2013 February | 21 | 22 | 43 |
| 2013 January | 21 | 18 | 39 |
| 2012 December | 13 | 21 | 34 |
| 2012 November | 23 | 33 | 56 |
| 2012 October | 11 | 12 | 23 |
| 2012 September | 16 | 4 | 20 |
| 2012 May | 4 | 0 | 4 |
| 2012 April | 2 | 0 | 2 |
| 2012 March | 4 | 0 | 4 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 6 | 0 | 6 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 3 | 0 | 3 |
| 2011 June | 2 | 0 | 2 |
| 2011 April | 3 | 0 | 3 |
| 2011 March | 6 | 0 | 6 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 15 | 0 | 15 |
| 2010 November | 5 | 0 | 5 |
Show all
