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Adherence to the SC biological drug &#40;the primary objective&#41; was evaluated by calculating the Medication Possession Ratio &#91;MPR&#93;&#44; considering a MPR&#8239;&#8804;&#8239;80&#37; as non-adherence&#46; The information about the design and main findings has already been published&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The patients also filled out a questionnaire developed by the EXPRESAR<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> group on their satisfaction and expectations&#46; This evaluated their degree of satisfaction with the efficacy and tolerability of the treatment on a Likert scale &#40;from &#8220;very dissatisfied&#8221; to &#8220;very satisfied&#8221;&#41;&#44; and fulfilment of their expectations was assessed from &#8220;much better&#8221; to &#8220;much worse than expected&#8221;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In this work we describe the degree to which patients were satisfied with the treatment and how far it fulfilled their expectations&#46; We study whether there are any differences between administration regimes for the SC biological drug&#44; as well as if the percentage of non-adherence differs according to the degree of satisfaction and the fulfilment of expectations&#46; The patients were classified according to the administration regime of the SC biological drug they were taking&#44; as weekly&#44; fortnightly or monthly&#46; Regarding their level of satisfaction they were divided into &#8220;satisfied&#47;very satisfied&#8221; or &#8220;neutral&#47;dissatisfied&#8221;&#44; and respecting the fulfilment of their expectations&#44; they were divided into &#8220;much&#47;quite a lot better than expected&#8221;&#44; and &#8220;more or less as expected&#8221; or &#8220;quite a lot&#47;much less than expected&#8221;&#46; The descriptive data are shown with core tendency measurements&#44; scatter and percentages&#46; The differences between percentages were analysed using the chi-squared test or Fischer&#8217;s exact test&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">From May 2014 to September 2015 364 patients were recruited &#40;54&#46;9 years old &#91;SD&#58; 12&#46;5&#93;&#59; 77&#46;5&#37; were women&#44; with median duration of RA of 7&#46;8 years &#91;interquartile range&#58; 3&#46;4&#8211;15&#46;7&#93;&#41;&#46; The interval between administrations of the SC biological drug was weekly &#40;n&#8239;&#61;&#8239;161&#44; 44&#46;2&#37;&#41;&#44; fortnightly &#40;n&#8239;&#61;&#8239;140&#59; 38&#46;5&#37;&#41; or monthly &#40;n&#8239;&#61;&#8239;63&#59; 17&#46;3&#37;&#41;&#46; As well as the SC biological drug&#44; 77&#46;2&#37; were also being treated with oral anti-rheumatic drugs and 31&#46;6&#37; were taking non-biological SC anti-rheumatic drugs&#46; The 346 patients who filled out the EXPRESAR group questionnaire had similar characteristics&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A very high percentage of the patients were satisfied&#47;very satisfied with the efficacy of the treatment &#40;close to or higher than 80&#37; in all aspects except for foot pain &#91;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#93;&#41;&#46; 64&#46;4&#37; considered themselves to be satisfied&#47;very satisfied with tolerability &#40;side effects or discomfort&#41;&#46; The percentages of patients who were satisfied&#47;very satisfied with efficacy &#40;question 1&#41; were very similar in the patients with weekly&#44; fortnightly and monthly administration&#44; while the percentages who were satisfied&#47;very satisfied with the side effects or discomfort were 63&#46;9&#37;&#44; 61&#46;2&#37; and 72&#46;9&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;176&#41;&#46; The percentage of patients who did not adhere to their SC biological drug regime amounted to 14&#46;7&#37; of those who were satisfied with efficacy and 8&#46;3&#37; of those who were neutral&#47;dissatisfied &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;339&#41;&#46; The percentages of non-adherence were very similar respecting side effects &#40;13&#46;1&#37; vs&#46; 15&#46;4&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;504&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the degree to which expectations were fulfilled&#46; The majority stated that the effect had been greater than expected&#44; without differences here between different administration regimes&#46; The percentages of non-adherence were 15&#46;5&#37; among those who considered the effect to be greater than expected&#44; 12&#46;6&#37; among those considered it to be similar and 10&#46;7&#37; of those who described it as less than expected &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;667&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Half of the patients considered that the discomfort caused by administration were quite or much less than expected or were absent&#44; and this percentage was higher in the patients with monthly administration &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;049&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The percentages who said that it caused no discomfort were 17&#46;8&#37; &#40;weekly administration&#41;&#44; 29&#46;3&#37; &#40;fortnightly&#41; and 35&#46;0&#37; &#40;monthly&#44; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;013&#41;&#46; The percentages of non-adherence were 15&#46;6&#37; in those with more discomfort than expected&#44; 18&#46;5&#37; in those with an expected level of discomfort and 11&#46;1&#37; in those with less discomfort than expected or without discomfort &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;189&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the ARCO study we reported a higher rate of adherence to the SC biological drug with monthly administration&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the current study we examine possible differences in greater depth from the viewpoint of patient experience which can be associated with adherence&#44; apart from the administration regime itself&#46; Although no significant differences were found in adherence according to degree of satisfaction or the fulfilment of expectations&#44; and with the limitation of sample size&#44; the information supplied by the patients contains relevant data&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">There was a very high level of satisfaction with the therapeutic effect&#44; without differences between administration regimes&#46; This finding fits with the high level of efficacy of the biological drugs&#44; which is similar for all of them&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and it also agrees with the findings of a recent survey in our field of 592 patients&#44; who expressed a level of satisfaction with the efficacy of the SC biological drug of &#8776;80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Although there was less satisfaction with the side effects&#44; it still attained a high level &#40;64&#37;&#41;&#44; with slight differences that were not significant between administration regimes&#46; This aspect is relevant as these patients generally require chronic treatment&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The expectations patients feel when they start a treatment and whether they are fulfilled are also relevant&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In our study the percentage who stated that they felt less discomfort than expected or no discomfort at all was highest in the patients with a monthly dose requiring fewer injections&#46; The study cannot determine whether this finding is due to the lower number of injections in itself or to better tolerability of the drug&#46; The percentage of non-adherence stood at 11&#46;1&#37; in the patients with less discomfort than expected or no discomfort&#46; This figure is slightly lower than the 18&#46;5&#37; and 15&#46;6&#37; of non-adherence in patients with &#8220;expected or more than expected discomfort&#8221;&#46; The doctor&#8211;patient relationship was also said to be an important factor in improving adherence&#58; expertise regarding the disease and feeling expectations with the patients about the effect and tolerability of the treatment may lead to benefits in terms of better adhesion and clinical results&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Our study has several limitations&#46; The sample size &#40;n&#8239;&#61;&#8239;346&#41; lacks the power necessary to find significant differences between adherence percentages&#44; although it does suggest that patients whose expectations of tolerability were fulfilled displayed better adherence&#46; The majority of the patients said they were satisfied or very satisfied with the efficacy of the treatment&#44; hindering evaluation of the percentages of adherence according to this variable&#46; At the time the study was undertaken&#44; the only SC biological drugs were anti-TNF alpha&#59; there are now SC biological drugs with other mechanisms of action&#46; Given all of these considerations&#44; exploring patient-related aspects &#40;belief in the medication&#44; expectations and experience&#41; is of interest in taking steps to improve adherence and clinical results&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and this work offers interesting information in these fields&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">To conclude&#44; the patients with RA who were treated with SC biological drugs expressed a high level of satisfaction and fulfilment of their expectations respecting the efficacy of the treatment&#46; Although the percentage of patients who were satisfied with its tolerability was also high&#44; it was lower than it was for efficacy&#46; The fulfilment of expectations seems to be higher with a monthly injection regime&#44; so that this&#44; together with the fact that fewer SC injections are needed&#44; may contribute to adherence to treatment with the drug&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financing</span><p id="par0070" class="elsevierStylePara elsevierViewall">The ARCO study was financed by <span class="elsevierStyleGrantSponsor" id="gs0005">Merck Sharp &#38; Dohme&#44; Spain</span>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">Luis Cea-Calvo is a full-time employee of Merck Sharp &#38; Dohme in Spain&#46; The other authors have no conflict of interests to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2017-10-05"
    "fechaAceptado" => "2018-02-22"
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          "clase" => "keyword"
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            0 => "Rheumatoid arthritis"
            1 => "Biological drugs"
            2 => "Adherence"
            3 => "Expectations"
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          "palabras" => array:4 [
            0 => "Artritis reumatoide"
            1 => "F&#225;rmacos biol&#243;gicos"
            2 => "Adherencia"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In the ARCO study&#44; adherence to subcutaneous biological agents by patients with rheumatoid arthritis improved with monthly administration&#46; We assess whether adherence can be related to fulfilment of expectations and satisfaction with treatment&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adherence was assessed by calculating the Medication Possession Ratio&#44; and satisfaction and fulfilment of expectations using the EXPRESAR group questionnaire&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 346 patients&#44; those who were satisfied&#47;very satisfied with efficacy and tolerability were &#8805;80&#37; and 64&#46;4&#37;&#44; with no differences between weekly&#44; biweekly or monthly administration regimens&#46; Regarding the fulfilment of expectations&#44; 59&#46;9&#37; considered the effect of the treatment greater than expected and 52&#46;6&#37; reported lower&#47;much lower than expected discomfort&#59; the latter percentage was higher in patients with monthly administration &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;049&#41;&#46; The percentages for nonadherence were 15&#46;6&#37; &#40;discomfort greater than expected&#41;&#44; 18&#46;5&#37; &#40;expected discomfort&#41; and 11&#46;1&#37; &#40;lower than expected or no discomfort&#41; &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;189&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Satisfaction and fulfilment of expectations were high&#46; Fulfilment of expectations of tolerability was better with monthly administration&#44; which could contribute to better adherence&#46;</p></span>"
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            "identificador" => "abst0005"
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            "identificador" => "abst0010"
            "titulo" => "Patients and methods"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En el estudio ARCO&#44; la adherencia al biol&#243;gico subcut&#225;neo en pacientes con artritis reumatoide fue mejor con administraci&#243;n mensual&#46; Evaluamos si satisfacci&#243;n y cumplimiento de expectativas pueden relacionarse con la adherencia al tratamiento&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La adherencia se evalu&#243; calculando el &#205;ndice de Posesi&#243;n de Medicaci&#243;n&#44; y satisfacci&#243;n y cumplimiento de expectativas mediante el cuestionario EXPRESAR&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En 346 pacientes&#44; los porcentajes satisfechos&#47;muy satisfechos con eficacia y tolerabilidad fueron &#8805;80&#37; y 64&#46;4&#37;&#44; sin diferencias entre pautas semanal&#44; cada dos semanas o mensual&#46; Sobre el cumplimiento de expectativas&#44; el 59&#46;9&#37; consider&#243; el efecto del tratamiento mayor al esperado&#44; y el 52&#46;6&#37; las molestias bastante&#47;mucho menores a las esperadas&#44; porcentaje mayor en pacientes con administraci&#243;n mensual p&#8239;&#61;&#8239;0&#44;049&#46; Los porcentajes de no-adherencia fueron 15&#46;6&#37; &#40;molestias mayores a las esperadas&#41;&#44; 18&#46;5&#37; &#40;molestias esperadas&#41; y 11&#46;1&#37; menores&#47;sin molestias p&#8239;&#61;&#8239;0&#44;189&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La satisfacci&#243;n y el cumplimiento de expectativas fueron altos&#46; El cumplimiento de expectativas de tolerabilidad fue mejor con administraci&#243;n mensual&#44; lo que podr&#237;a contribuir a una mejor adherencia&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Calvo-Al&#233;n J&#44; Vela P&#44; Bustabad S&#44; Maceiras F&#44; Carmona L&#44; Cea-Calvo L&#46; Satisfacci&#243;n&#44; cumplimento de expectativas y adherencia al f&#225;rmaco biol&#243;gico subcut&#225;neo en pacientes con artritis reumatoide&#46; Estudio ARCO&#46; Reumatol Clin&#46; 2020&#59;16&#58;116&#8211;119&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No&#46; &#40;&#37;&#41; satisfied or very satisfied&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">1&#46; Do you feel satisfied with its efficacy&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">301 &#40;86&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">2&#46; Do you feel satisfied with how it is controlling symptoms&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">301 &#40;86&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">3&#46; Do you feel satisfied with the treatment regarding pain in your joints in general&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">291 &#40;83&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">4&#46; Do you feel satisfied with the treatment regarding pain in your hands&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">274 &#40;78&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">5&#46; Do you feel satisfied with the treatment regarding pain in your feet&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">239 &#40;68&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">6&#46; Do you feel satisfied with the treatment regarding the reduction of joint inflammation&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">297 &#40;85&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46; Do you feel satisfied with the side effects or discomfort &#40;such as dizziness or stomach pain&#41;&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222 &#40;64&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Percentages of patients who answered that they were satisfied or very satisfied in reply to the EXPRESAR group questionnaire&#46;</p>"
        ]
      ]
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            "identificador" => "at0010"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">SC&#58; subcutaneous&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All &#40;n&#8239;&#61;&#8239;346&#41; &#37;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Administration regime</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Weekly &#40;n&#8239;&#61;&#8239;152&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fortnightly &#40;n&#8239;&#61;&#8239;133&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Monthly &#40;n&#8239;&#61;&#8239;60&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Do you consider that the effect of treatment for your rheumatoid arthritis has been&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot&#47;quite a lot more than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;573</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite&#47;a lot less than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">The presence of discomfort caused by the administration of the treatment has been&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot&#47;quite a lot more than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;048</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite a lot&#47;a lot less than expected&#44; or it has not caused discomfort&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fulfillment of expectations in terms of efficacy and tolerability according to the administration regime of the SC biological drug&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
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        0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Medication adherence of patients with selected rheumatic conditions&#58; a systematic review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;R&#46; Harrold"
                            1 => "S&#46;E&#46; Andrade"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "SeminArthritis Rheum"
                        "fecha" => "2009"
                        "volumen" => "385"
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                  "contribucion" => array:1 [
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                      "titulo" => "The rate of adherence to antiarthritis medications and associated factors among patients with rheumatoid arthritis&#58; a systematic literature review and metaanalysis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Scheiman-Elazary"
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                            2 => "C&#46; Shourt"
                            3 => "H&#46; Agrawal"
                            4 => "D&#46; Ellashof"
                            5 => "M&#46; Cameron-Hay"
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                    0 => array:2 [
                      "doi" => "10.3899/jrheum.141371"
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                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2016"
                        "volumen" => "43"
                        "paginaInicial" => "512"
                        "paginaFinal" => "523"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26879354"
                            "web" => "Medline"
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            2 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors associated with adherence to pharmaceutical treatment for rheumatoid arthritis patients&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Pasma"
                            1 => "A&#46; van&#8217;t Spijker"
                            2 => "J&#46;M&#46; Hazes"
                            3 => "J&#46;J&#46; Busschbach"
                            4 => "J&#46;J&#46; Luime"
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                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2012.12.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2013"
                        "volumen" => "43"
                        "paginaInicial" => "18"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23352247"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A systematic review of factors associated with non-adherence to treatment for immune-mediated inflammatory diseases"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Vangeli"
                            1 => "S&#46; Bakhshi"
                            2 => "A&#46; Baker"
                            3 => "A&#46; Fisher"
                            4 => "D&#46; Bucknor"
                            5 => "U&#46; Mrowietz"
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12325-015-0256-7"
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                        "tituloSerie" => "Adv Ther"
                        "fecha" => "2015"
                        "volumen" => "32"
                        "paginaInicial" => "983"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26547912"
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              "identificador" => "bib0025"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-adherence to subcutaneous biological medication in patients with rheumatoid arthritis&#58; a multicentre&#44; non-interventional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Calvo-Al&#233;n"
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Brief Report
Satisfaction, fulfillment of expectations and adherence to subcutaneous biological drugs in patients with rheumatoid arthritis: ARCO study
Satisfacción, cumplimento de expectativas y adherencia al fármaco biológico subcutáneo en pacientes con artritis reumatoide. Estudio ARCO
Jaime Calvo-Aléna, Paloma Velab, Sagrario Bustabadc, Francisco Maceirasd, Loreto Carmonae, Luis Cea-Calvof,
Corresponding author
luis.cea@merck.com

Corresponding author.
a Servicio de Reumatología, Hospital Txagorritxu, Vitoria-Gasteiz, Álava, Spain
b Servicio de Reumatología, Hospital Universitario de Alicante, Alicante, Spain
c Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Tenerife, Spain
d Servicio de Reumatología, Complexo Universitario de Vigo, Vigo, La Coruña, Spain
e Instituto de Salud Musculoesquelética, Madrid, Spain
f Medical Affairs, Merck Sharp & Dohme de España, Spain
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    "titulo" => "Satisfaction&#44; fulfillment of expectations and adherence to subcutaneous biological drugs in patients with rheumatoid arthritis&#58; ARCO study"
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        "titulo" => "Satisfacci&#243;n&#44; cumplimento de expectativas y adherencia al f&#225;rmaco biol&#243;gico subcut&#225;neo en pacientes con artritis reumatoide&#46; Estudio ARCO"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; requires chronic treatment&#44; and adherence to this is important to gain the best therapeutic results&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Nevertheless&#44; adherence to anti-rheumatic medication is sub-optimum&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and the lack of adherence has been associated with the type of medication&#44; the administration regime&#44; the psychological characteristics of patients or beliefs respecting the medication&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One aspect that has been studied less is the relationship between adherence and the expectations and degree of satisfaction of patients regarding treatment&#46; In the study &#8220;Adherence of Rheumatoid arthritis patients to subCutaneous and Oral drugs&#8221; &#40;ARCO&#41;&#44; of 364 patients with RA&#44; we described how&#44; during the first 14 months of treatment&#44; 14&#46;3&#37; of these patients did not adhere to the prescribed subcutaneous &#40;SC&#41; biological drug&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and that the percentage of non-adherent patients was lower in those for whom administration was monthly &#40;6&#46;4&#37;&#41; than it was for patients treated every fortnight &#40;14&#46;4&#37;&#41; or weekly &#40;17&#46;4&#37;&#41;&#46; This work has two objectives&#58; 1&#41; to describe the degree of satisfaction and fulfilment of expectations of the patients with their treatment&#44; and 2&#41; to evaluate whether there are differences between administration regimes that may contribute to a higher level of adherence&#44; apart from the regime itself&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">ARCO was a multicentre retrospective study in patients &#8805;18 years old with RA who had started taking a SC biological therapy 12&#8211;18 months before the study&#46; Adherence to the SC biological drug &#40;the primary objective&#41; was evaluated by calculating the Medication Possession Ratio &#91;MPR&#93;&#44; considering a MPR&#8239;&#8804;&#8239;80&#37; as non-adherence&#46; The information about the design and main findings has already been published&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The patients also filled out a questionnaire developed by the EXPRESAR<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> group on their satisfaction and expectations&#46; This evaluated their degree of satisfaction with the efficacy and tolerability of the treatment on a Likert scale &#40;from &#8220;very dissatisfied&#8221; to &#8220;very satisfied&#8221;&#41;&#44; and fulfilment of their expectations was assessed from &#8220;much better&#8221; to &#8220;much worse than expected&#8221;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In this work we describe the degree to which patients were satisfied with the treatment and how far it fulfilled their expectations&#46; We study whether there are any differences between administration regimes for the SC biological drug&#44; as well as if the percentage of non-adherence differs according to the degree of satisfaction and the fulfilment of expectations&#46; The patients were classified according to the administration regime of the SC biological drug they were taking&#44; as weekly&#44; fortnightly or monthly&#46; Regarding their level of satisfaction they were divided into &#8220;satisfied&#47;very satisfied&#8221; or &#8220;neutral&#47;dissatisfied&#8221;&#44; and respecting the fulfilment of their expectations&#44; they were divided into &#8220;much&#47;quite a lot better than expected&#8221;&#44; and &#8220;more or less as expected&#8221; or &#8220;quite a lot&#47;much less than expected&#8221;&#46; The descriptive data are shown with core tendency measurements&#44; scatter and percentages&#46; The differences between percentages were analysed using the chi-squared test or Fischer&#8217;s exact test&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">From May 2014 to September 2015 364 patients were recruited &#40;54&#46;9 years old &#91;SD&#58; 12&#46;5&#93;&#59; 77&#46;5&#37; were women&#44; with median duration of RA of 7&#46;8 years &#91;interquartile range&#58; 3&#46;4&#8211;15&#46;7&#93;&#41;&#46; The interval between administrations of the SC biological drug was weekly &#40;n&#8239;&#61;&#8239;161&#44; 44&#46;2&#37;&#41;&#44; fortnightly &#40;n&#8239;&#61;&#8239;140&#59; 38&#46;5&#37;&#41; or monthly &#40;n&#8239;&#61;&#8239;63&#59; 17&#46;3&#37;&#41;&#46; As well as the SC biological drug&#44; 77&#46;2&#37; were also being treated with oral anti-rheumatic drugs and 31&#46;6&#37; were taking non-biological SC anti-rheumatic drugs&#46; The 346 patients who filled out the EXPRESAR group questionnaire had similar characteristics&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A very high percentage of the patients were satisfied&#47;very satisfied with the efficacy of the treatment &#40;close to or higher than 80&#37; in all aspects except for foot pain &#91;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#93;&#41;&#46; 64&#46;4&#37; considered themselves to be satisfied&#47;very satisfied with tolerability &#40;side effects or discomfort&#41;&#46; The percentages of patients who were satisfied&#47;very satisfied with efficacy &#40;question 1&#41; were very similar in the patients with weekly&#44; fortnightly and monthly administration&#44; while the percentages who were satisfied&#47;very satisfied with the side effects or discomfort were 63&#46;9&#37;&#44; 61&#46;2&#37; and 72&#46;9&#37;&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;176&#41;&#46; The percentage of patients who did not adhere to their SC biological drug regime amounted to 14&#46;7&#37; of those who were satisfied with efficacy and 8&#46;3&#37; of those who were neutral&#47;dissatisfied &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;339&#41;&#46; The percentages of non-adherence were very similar respecting side effects &#40;13&#46;1&#37; vs&#46; 15&#46;4&#37;&#44; respectively&#59; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;504&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the degree to which expectations were fulfilled&#46; The majority stated that the effect had been greater than expected&#44; without differences here between different administration regimes&#46; The percentages of non-adherence were 15&#46;5&#37; among those who considered the effect to be greater than expected&#44; 12&#46;6&#37; among those considered it to be similar and 10&#46;7&#37; of those who described it as less than expected &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;667&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Half of the patients considered that the discomfort caused by administration were quite or much less than expected or were absent&#44; and this percentage was higher in the patients with monthly administration &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;049&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The percentages who said that it caused no discomfort were 17&#46;8&#37; &#40;weekly administration&#41;&#44; 29&#46;3&#37; &#40;fortnightly&#41; and 35&#46;0&#37; &#40;monthly&#44; <span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;013&#41;&#46; The percentages of non-adherence were 15&#46;6&#37; in those with more discomfort than expected&#44; 18&#46;5&#37; in those with an expected level of discomfort and 11&#46;1&#37; in those with less discomfort than expected or without discomfort &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;189&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the ARCO study we reported a higher rate of adherence to the SC biological drug with monthly administration&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the current study we examine possible differences in greater depth from the viewpoint of patient experience which can be associated with adherence&#44; apart from the administration regime itself&#46; Although no significant differences were found in adherence according to degree of satisfaction or the fulfilment of expectations&#44; and with the limitation of sample size&#44; the information supplied by the patients contains relevant data&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">There was a very high level of satisfaction with the therapeutic effect&#44; without differences between administration regimes&#46; This finding fits with the high level of efficacy of the biological drugs&#44; which is similar for all of them&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and it also agrees with the findings of a recent survey in our field of 592 patients&#44; who expressed a level of satisfaction with the efficacy of the SC biological drug of &#8776;80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Although there was less satisfaction with the side effects&#44; it still attained a high level &#40;64&#37;&#41;&#44; with slight differences that were not significant between administration regimes&#46; This aspect is relevant as these patients generally require chronic treatment&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The expectations patients feel when they start a treatment and whether they are fulfilled are also relevant&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In our study the percentage who stated that they felt less discomfort than expected or no discomfort at all was highest in the patients with a monthly dose requiring fewer injections&#46; The study cannot determine whether this finding is due to the lower number of injections in itself or to better tolerability of the drug&#46; The percentage of non-adherence stood at 11&#46;1&#37; in the patients with less discomfort than expected or no discomfort&#46; This figure is slightly lower than the 18&#46;5&#37; and 15&#46;6&#37; of non-adherence in patients with &#8220;expected or more than expected discomfort&#8221;&#46; The doctor&#8211;patient relationship was also said to be an important factor in improving adherence&#58; expertise regarding the disease and feeling expectations with the patients about the effect and tolerability of the treatment may lead to benefits in terms of better adhesion and clinical results&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Our study has several limitations&#46; The sample size &#40;n&#8239;&#61;&#8239;346&#41; lacks the power necessary to find significant differences between adherence percentages&#44; although it does suggest that patients whose expectations of tolerability were fulfilled displayed better adherence&#46; The majority of the patients said they were satisfied or very satisfied with the efficacy of the treatment&#44; hindering evaluation of the percentages of adherence according to this variable&#46; At the time the study was undertaken&#44; the only SC biological drugs were anti-TNF alpha&#59; there are now SC biological drugs with other mechanisms of action&#46; Given all of these considerations&#44; exploring patient-related aspects &#40;belief in the medication&#44; expectations and experience&#41; is of interest in taking steps to improve adherence and clinical results&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and this work offers interesting information in these fields&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">To conclude&#44; the patients with RA who were treated with SC biological drugs expressed a high level of satisfaction and fulfilment of their expectations respecting the efficacy of the treatment&#46; Although the percentage of patients who were satisfied with its tolerability was also high&#44; it was lower than it was for efficacy&#46; The fulfilment of expectations seems to be higher with a monthly injection regime&#44; so that this&#44; together with the fact that fewer SC injections are needed&#44; may contribute to adherence to treatment with the drug&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financing</span><p id="par0070" class="elsevierStylePara elsevierViewall">The ARCO study was financed by <span class="elsevierStyleGrantSponsor" id="gs0005">Merck Sharp &#38; Dohme&#44; Spain</span>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">Luis Cea-Calvo is a full-time employee of Merck Sharp &#38; Dohme in Spain&#46; The other authors have no conflict of interests to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In the ARCO study&#44; adherence to subcutaneous biological agents by patients with rheumatoid arthritis improved with monthly administration&#46; We assess whether adherence can be related to fulfilment of expectations and satisfaction with treatment&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adherence was assessed by calculating the Medication Possession Ratio&#44; and satisfaction and fulfilment of expectations using the EXPRESAR group questionnaire&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 346 patients&#44; those who were satisfied&#47;very satisfied with efficacy and tolerability were &#8805;80&#37; and 64&#46;4&#37;&#44; with no differences between weekly&#44; biweekly or monthly administration regimens&#46; Regarding the fulfilment of expectations&#44; 59&#46;9&#37; considered the effect of the treatment greater than expected and 52&#46;6&#37; reported lower&#47;much lower than expected discomfort&#59; the latter percentage was higher in patients with monthly administration &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;049&#41;&#46; The percentages for nonadherence were 15&#46;6&#37; &#40;discomfort greater than expected&#41;&#44; 18&#46;5&#37; &#40;expected discomfort&#41; and 11&#46;1&#37; &#40;lower than expected or no discomfort&#41; &#40;<span class="elsevierStyleItalic">P</span>&#8239;&#61;&#8239;&#46;189&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Satisfaction and fulfilment of expectations were high&#46; Fulfilment of expectations of tolerability was better with monthly administration&#44; which could contribute to better adherence&#46;</p></span>"
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            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Patients and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En el estudio ARCO&#44; la adherencia al biol&#243;gico subcut&#225;neo en pacientes con artritis reumatoide fue mejor con administraci&#243;n mensual&#46; Evaluamos si satisfacci&#243;n y cumplimiento de expectativas pueden relacionarse con la adherencia al tratamiento&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La adherencia se evalu&#243; calculando el &#205;ndice de Posesi&#243;n de Medicaci&#243;n&#44; y satisfacci&#243;n y cumplimiento de expectativas mediante el cuestionario EXPRESAR&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En 346 pacientes&#44; los porcentajes satisfechos&#47;muy satisfechos con eficacia y tolerabilidad fueron &#8805;80&#37; y 64&#46;4&#37;&#44; sin diferencias entre pautas semanal&#44; cada dos semanas o mensual&#46; Sobre el cumplimiento de expectativas&#44; el 59&#46;9&#37; consider&#243; el efecto del tratamiento mayor al esperado&#44; y el 52&#46;6&#37; las molestias bastante&#47;mucho menores a las esperadas&#44; porcentaje mayor en pacientes con administraci&#243;n mensual p&#8239;&#61;&#8239;0&#44;049&#46; Los porcentajes de no-adherencia fueron 15&#46;6&#37; &#40;molestias mayores a las esperadas&#41;&#44; 18&#46;5&#37; &#40;molestias esperadas&#41; y 11&#46;1&#37; menores&#47;sin molestias p&#8239;&#61;&#8239;0&#44;189&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La satisfacci&#243;n y el cumplimiento de expectativas fueron altos&#46; El cumplimiento de expectativas de tolerabilidad fue mejor con administraci&#243;n mensual&#44; lo que podr&#237;a contribuir a una mejor adherencia&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Pacientes y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Calvo-Al&#233;n J&#44; Vela P&#44; Bustabad S&#44; Maceiras F&#44; Carmona L&#44; Cea-Calvo L&#46; Satisfacci&#243;n&#44; cumplimento de expectativas y adherencia al f&#225;rmaco biol&#243;gico subcut&#225;neo en pacientes con artritis reumatoide&#46; Estudio ARCO&#46; Reumatol Clin&#46; 2020&#59;16&#58;116&#8211;119&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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          0 => array:3 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No&#46; &#40;&#37;&#41; satisfied or very satisfied&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46; Do you feel satisfied with its efficacy&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">301 &#40;86&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46; Do you feel satisfied with how it is controlling symptoms&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">301 &#40;86&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46; Do you feel satisfied with the treatment regarding pain in your joints in general&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">291 &#40;83&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46; Do you feel satisfied with the treatment regarding pain in your hands&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">274 &#40;78&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46; Do you feel satisfied with the treatment regarding pain in your feet&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">239 &#40;68&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46; Do you feel satisfied with the treatment regarding the reduction of joint inflammation&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">297 &#40;85&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46; Do you feel satisfied with the side effects or discomfort &#40;such as dizziness or stomach pain&#41;&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222 &#40;64&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Percentages of patients who answered that they were satisfied or very satisfied in reply to the EXPRESAR group questionnaire&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">SC&#58; subcutaneous&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All &#40;n&#8239;&#61;&#8239;346&#41; &#37;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Administration regime</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Weekly &#40;n&#8239;&#61;&#8239;152&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fortnightly &#40;n&#8239;&#61;&#8239;133&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Monthly &#40;n&#8239;&#61;&#8239;60&#41; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Do you consider that the effect of treatment for your rheumatoid arthritis has been&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot&#47;quite a lot more than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;573</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite&#47;a lot less than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">The presence of discomfort caused by the administration of the treatment has been&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot&#47;quite a lot more than expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;048</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">35&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">23&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite a lot&#47;a lot less than expected&#44; or it has not caused discomfort&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">52&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">46&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">53&#46;2&nbsp;\t\t\t\t\t\t\n
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Idiomas
Reumatología Clínica (English Edition)
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