Publish in this journal
Journal Information
Vol. 18. Issue 7.
Pages 422-428 (August - September 2022)
Download PDF
More article options
Vol. 18. Issue 7.
Pages 422-428 (August - September 2022)
Original Article
Hospitalization and mortality from COVID-19 of patients with rheumatic inflammatory diseases in Andalusia
Hospitalizaciones y mortalidad por COVID-19 en pacientes con enfermedades inflamatorias reumáticas en Andalucía
Natalia Mena-Vázqueza,b, Sara Manrique Arijaa,b,
Corresponding author

Corresponding author.
, Marta Rojas-Giménezc,d, Enrique Raya-ÿlvareze, María Luisa Velloso-Feijoóf, C. López-Medinac,d, Consuelo Ramos-Giraldezf, Francisco Javier Godoy-Navarretea,b, Rocío Redondo-Rodrígueza,b, Alba María Cabezas-Lucenaa,b, M. Morales-ÿguilaa,b, C.M. Romero-Barcoa,g, Antonio Fernández-Nebroa,b,h
a Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
b UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain
c Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
d Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain
e Hospital Universitario San Cecilio, Granada, Spain
f Hospital Virgen De Valme, Sevilla, Spain
g Hospital Universitario Virgen de la Victoria de Málaga, Málaga, Spain
h Departamento de Medicina, Universidad de Málaga, Málaga, Spain
Article information
Full Text
Download PDF

To describe whether rheumatic inflammatory diseases (RID) are associated with a higher risk of hospitalization and/or mortality from COVID-19 and identify the factors associated with hospitalization and mortality in RID and COVID-19 in different Hospitals in Andalusia.


Design: Multicentre observational case-COntrol study. Patients: RID and COVID-19 from different centres in Andalusia. Controls: patients without RIS matched by sex, age and CRP-COVID.

Protocol A list of patients with PCR for COVID-19 was requested from the microbiology service from March 14 to April 14, 2020. The patients who had RID were identified and then consecutively a paired control for each case.

Variables The main outcome variable was hospital admission and mortality from COVID-19.

Statistical analysis Bivariate followed by binary logistic regression models (DV: mortality/hospital admission).


One hundred and fifty-six patients were included, 78 with RID and COVID-19 and 78 without RID with COVID-19. The patients did not present characteristics of COVID-19 disease different from the general population, nor did they present higher hospital admission or mortality. The factor associated with mortality in patients with RID was advanced age (OR [95% CI], 1.1 [1.0–1.2]; P= .025), while the factors associated with hospitalization were advanced age (OR [95% CI], 1.1 [1.0–1.1]; P = .007) and hypertension (OR [95% CI], 3.9 [1.5–6.7]; P = .003).


Mortality and hospital admission due to COVID-19 do not seem to increase in RID. Advanced age was associated with mortality in RID and, in addition, HTN was associated with hospital admission.

Rheumatic inflammatory disease

Describir si las enfermedades inflamatorias reumáticas (EIR) se asocian con mayor riesgo de hospitalización y/o mortalidad por COVID-19 e identificar los factores asociados a la hospitalización y mortalidad en EIR y COVID-19 en diferentes hospitales de Andalucía.


Diseño: Estudio multicéntrico observacional de casos y controles. Pacientes Casos: EIR y COVID-19 de diferentes centros de Andalucía. Controles: pacientes sin EIR pareados por sexo, edad y PCR-COVID.

Protocolo Se solicitó al Servicio de Microbiología un listado de pacientes con PCR para COVID-19 desde 14 de marzo al 14 de abril de 2020. Se identificaron los pacientes que tuvieran EIR y luego consecutivamente un control pareado para cada caso.

Variables La variable de desenlace principal fue ingreso hospitalario y mortalidad por COVID-19.

Análisis estadístico Bivariante seguida de modelos de regresión logística binaria (variable dependiente: mortalidad/ingreso hospitalario).


Se incluyeron 156 pacientes con COVID-19, 78 con EIR y 78 sin EIR. Los pacientes con EIR no presentaron características de la enfermedad COVID-19 diferentes a la población general, tampoco mayor ingreso hospitalario ni mortalidad. El factor asociado con mortalidad en los pacientes con EIR fue edad (OR [IC 95%], 1,1 [1,0–1,2]; p = 0,025), mientras que los factores asociados con ingreso hospitalario fueron edad (OR [IC 95%], 1,1 [1,1–1,2]; p = 0,007) e hipertensión arterial (OR [IC 95%], 3,9 [1,5–6,7]; p = 0,003).


La mortalidad y el ingreso hospitalario por COVID-19 no parecen aumentados en las EIR. La edad se asoció con mortalidad en EIR y, además, la hipertensión arterial se asoció con ingreso hospitalario.

Palabras clave:
Enfermedad inflamatoria reumática


These are the options to access the full texts of the publication Reumatología Clínica (English Edition)
If you are member of Sociedad Española de Reumatología (SER) or the Colegio Mexicano de Reumatología (CMR):
Please go to the member area of SER or CMR and log in.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Reumatología Clínica (English Edition)

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?