Publish in this journal
Journal Information
Vol. 11. Issue 1.
Pages 54-55 (January - February 2015)
Vol. 11. Issue 1.
Pages 54-55 (January - February 2015)
Images in Clinical Rheumatology
Full text access
Isolated Splenic Sarcoidosis
Sarcoidosis espl��nica aislada
Antonio Ruiz Serratoa,
Corresponding author

Corresponding author.
, M. ��ngeles Guerrero Le��na, Juan Jim��nez Mart��nb, Desir��e G��mez Loraa
a Servicio de Medicina Interna, Hospital de Antequera, M��laga, Spain
b Servicio de Anatom��a Patol��gica, Hospital de Antequera, M��laga, Spain
Article information
Full Text
Download PDF
Figures (3)
Show moreShow less
Full Text

A 37-year-old Caucasian woman, with no medical history of interest was seen at the clinic. She had presented epigastric and left hypochondrial mild, intermittent pain for years, with a daily frequency and with no relation to meals, having no other associated systemic symptoms. Physical examination was normal. Laboratory studies showed normal acute phase reactants, peripheral blood smear and angiotensin converting enzyme, as well as proteins and autoimmunity, infectious disease (including hydatidosis) and a Mantoux test. Chest and abdomen test, gastrointestinal transit images and electrocardiogram were all normal. An abdominal ultrasound and thoracoabdominal computed tomography showed multiple splenic lesions measuring 7–9mm in diameter, with no spleen enlargement (Fig. 1). The abdominal magnetic resonance showed multiple lesions on the spleen, hypointense in T2 and isointense in T1, with homogeneous and late enhancement upon contrast, with a diameter under 1cm (Fig. 2). Due to the persistence of left hypochondrial pain as well as the diagnostic uncertainty, a laparoscopic splenectomy was programmed. Macroscopically, the spleen presented multiple external and intraparenchymal nodules of a white-fibrous aspect and with a diameter under 1cm; microbiological tests were negative and the lesions were histologically compatible with non-casefying epithelioid granulomas (Fig. 3). After the uncomplicated splenectomy, the patient remained asymptomatic and with no treatment during follow-up.

Fig. 1.

Abdominal contrast CT scan, which shows multiple spleen lesions with no contrast uptake (arrows).

Fig. 2.

Abdominal MIR with gadolinium center in T2 showing splenic lesions (arrows).

Fig. 3.

Microscopic histology of the spleen with non-casefying granulomas (arrows).


Sarcoidosis is a granulomatous multisystemic disease of unknown etiology.1 More than 90% of affected patients have pulmonary manifestations at the moment of diagnosis.2 The extrapulmonary multiorganic affection is frequent, with the spleen involved in 10% in imaging studies and up to 40% in autopsies,3 being asymptomatic only in 5%–7%.4 However, because the affection is exclusively splenic, as was seen in our patient, it is extraordinarily infrequent, and we consider it relevant to present because the correlation between clinical, imaging and histological testing has been seldom reported in previous case publications.5,6

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that they have followed the protocols of their work center on the publication of patient data.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflict of Interest

The authors state no conflicts of interest.

M.C. Iannuzzi, B.A. Rybicki, A.S. Teirstein.
N Engl J Med, 357 (2007), pp. 2153-2165
V. Vardhanabhuti, N. Venkatanarasimha, G. Bhatnagar, M. Maviki, S. Iyengar, W.M. Adams, et al.
Extra-pulmonary manifestations of sarcoidosis.
Clin Radiol, 67 (2012), pp. 263-276
K. Iwai, T. Tachibana, T. Takemura, Y. Matsui, M. Kitaichi, Y. Kawabata.
Pathological studies on sarcoidosis autopsy. I. Epidemiological features of 320 cases in Japan.
Acta Pathol Jpn, 43 (1993), pp. 372-376
H. Zia, H. Zemon, F. Brody.
Laparoscopic splenectomy for isolated sarcoidosis of the spleen.
J Laparoendosc Adv Surg Tech A, 15 (2005), pp. 160-162
S. Kay.
Sarcoidosis of the spleen; report of 4 cases with a 23-year follow up in one case.
Am J Pathol, 26 (1950), pp. 427-443
Y.T. Wang, Y.P. Han, H. Xu, H.Z. Chen, K. Sheng, Q. Li.
Splenic sarcoidosis: a case report and review of literature.
Zhonghua Nei Ke Za Zhi, 48 (2009), pp. 367-370

Please cite this article as: Ruiz Serrato A, Guerrero León MÁ, Jiménez Martín J, Gómez Lora D. Sarcoidosis esplénica aislada. Reumatol Clin. 2015;11:54–55.

Copyright © 2013. Elsevier España, S.L.U.. All rights reserved
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?