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Original Article
Available online 8 December 2021
JAK kinase inhibitors and varicella zoster virus infection in patients with rheumatoid arthritis. Systematic review of the literature
Inhibidores de receptores JAK quinasa e infección por virus varicela zoster en pacientes con artritis reumatoide. Revisión sistemática de la literatura
Carmen Olga Sánchez Gonzáleza,
Corresponding author

Corresponding author.
, Juan Carlos Nieto Gonzálezb
a Sección de Reumatología, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain
b Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Received 23 January 2021. Accepted 10 June 2021
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Figures (1)
Tables (5)
Table 1. Available JAK kinase inhibitors and under study in rheumatoid arthritis.
Table 2. Tofacitinib studies.
Table 3. Studies on baricitinib.
Table 4. Studies on upadacitinib and filgotinib.
Table 5. Studies on peficitinib and decernotinib.
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JAK kinase inhibitors (JAKi) are a new therapeutic option in the treatment of rheumatoid arthritis, but they are not without risks, especially the incidence of herpes zoster (HZ).

Material and methods

Systematic literature review that evaluates the incidence of HZ published in the clinical trials of the different JAK is marketed or under study.


The HZ rates ranged between 1.51 and 20.22. The results were expressed mainly as a percentage of events. The most recent studies better categorized the incidence of HZ and its severity.


JAK is are associated with an increased risk of HZ. Although the HZ rates of the selective JAK1 JAK is are lower, more studies are needed to confirm these results.

Rheumatoid arthritis
JAK inhibitors
Herpes zoster

El objetivo de esta revisión sistemática es evaluar la infección por herpes zoster (HZ) publicada en los ensayos clínicos fase II y fase III de pacientes con AR en tratamiento con inhibidores de JAK (iJAK).

Material y métodos

Revisión sistemática de la literatura que evalúa la incidencia de HZ publicada en los ensatyos clínicos de los distintos iJAK comercializados o en estudio.


Las tasas de HZ variaron entre el 1.51 y 20.22. Los resultados se expresaron principalmente en porcentaje de eventos. Los estudios más recientes categorizaron mejor la incidencia de HZ y su gravedad.


Los iJAK se asocian a mayor riesgo de HZ. Aunque las tasas de HZ de los iJAK sleectivos de JAK1 son menores, son necesarios más estudios que confirmen estos resultados.

Palabras clave:
Artritis reumatoide
Inhibidores de JAK
Herpes zoster


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