Publish in this journal
Journal Information
Vol. 16. Issue 6.
Pages 506-507 (November - December 2020)
Visits
...
Vol. 16. Issue 6.
Pages 506-507 (November - December 2020)
Images in Clinical Rheumatology
DOI: 10.1016/j.reumae.2018.08.013
Full text access
Tophaceous gout in a woman
Gota tofácea en una mujer
Visits
...
María José Pérez Galán
Corresponding author
mjpg77@hotmail.com

Corresponding author.
, Celia García Jiménez
Unidad de Reumatología, Complejo Hospitalario de Jaén, Jaén, Spain
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Full Text
Clinical case

A 76 year-old woman, with a history of anaemia and hyperuricemia treated with ferrous sulphate and 100 mg allopurinol per day. She states that she has consumed half a litre of alcohol-free beer per day for 15 years. She states that she has no history of arterial hypertension, no chronic disease and that she does not consume diuretics.

She visited our surgery due to arthralgia in the hands and feet with a crisis of pain and functional impotency in multiple joints that has evolved over more than 15 years. Physical examination found major tophaceous deposits in the hands and feet, most strikingly in the right hand (Fig. 1), with incapacity of grasping, above all in the right hand.

Figure 1.

Tophaceous deposits in the hands.

(0.06MB).

Analysis detected 7.7 mg/dl uricaemia, while the rest of basic biochemistry was normal. The haemogram, acute phase reagents, rheumatoid factor and anti-citrulline antibodies were normal or negative.

Bone X-ray imaging showed an important increase in the soft parts, with trapping and erosion in the metacarpophalangeal, proximal and distal interphalangeal joints of both hands (Fig. 2), as well as erosion on the first metatarsal joints and luxation of the 5th left metatarsal joint (Fig. 3).

Figure 2.

X-ray image of hands: increased soft parts and erosion.

(0.05MB).
Figure 3.

X-ray image of feet: erosion in the first metatarsophalangeal joints.

(0.08MB).
Diagnosis

Tophaceous gout.

Evol ution

Treatment with hygienic and dietary methods was prescribed, with colchicine and an increased dose of allopurinol to maintain uricaemia below 5 mg/dl.

Discussion

Gout arthropathy is more common in men1 than it is in women, although it is the most frequent inflammatory disease of the joints in post-menopausal women. The first manifestation of the disease is typically acute arthritis.2 Tophi are sodium urate monohydrate deposits surrounded by a granulomatous inflammatory reaction. They are a pathognomic characteristic of gout and can be detected by physical examination and/or imaging techniques.3

We present the case of a woman with tophaceous arthropathy. We recall the importance of maintaining suitable levels of uricaemia, as this disease is potentially disabling. We underline that although it occurs more frequently in men, it is the most common inflammatory arthropathy in post-menopausal women.

Conflict of interests

The authors have no conflict of interests to declare.

References
[1]
V. Bhole, Rahman M.M. de VM, E. Krishnan, H. Choi.
Epidemiology of gout in women: Fifty-two-year followup of a prospective cohort.
Arthritis Rheum, 62 (2010), pp. 1069-1076
[2]
T. Neogi.
Clinical practice.
Gout N Engl J Med, 364 (2011), pp. 443-452
[3]
Tophi, mainly in articular, periarticular, bursal, bone, auricular, and cutaneous tissues are a pathognomonic feature of gout, and are detectable by physical exam, and/or by imaging approaches and pathology examination.

Please cite this article as: Pérez Galán MJ, García Jiménez C. Gota tofácea en una mujer. Reumatol Clin. 2020;16:506–507.

Copyright © 2018. Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
Idiomas
Reumatología Clínica (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?