Eficacia y seguridad de las inyecciones intraarticulares de ácido hialurónico en la artrosis de rodilla. Evaluación clínica y ecográfica

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Díaz-Cobos, J.L. Callejas-Rubio, C. Ocaña-Medina, N. Ortego-Centeno, J. Sánchez-Román, E. de Ramón-Garrido, M.T. Camps-García" "autores" => array:8 [ 0 => array:2 [ "nombre" => "F.J." "apellidos" => "García-Hernández" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Díaz-Cobos" ] 2 => array:2 [ "nombre" => "J.L." "apellidos" => "Callejas-Rubio" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Ocaña-Medina" ] 4 => array:2 [ "nombre" => "N." "apellidos" => "Ortego-Centeno" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Sánchez-Román" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "de Ramón-Garrido" ] 7 => array:2 [ "nombre" => "M.T." 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Evaluación clínica y ecográfica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "15" "paginaFinal" => "22" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Navarro, G. Herrero-Beaumont, E. Naredo, J. Paulino, J. Tornero, I. Villanueva" "autores" => array:6 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Navarro" "email" => array:1 [ 0 => "federiconavarro@supercable.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Herrero-Beaumont" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Naredo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff3" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Paulino" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff4" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Tornero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff5" ] ] ] 5 => array:3 [ "nombre" => "I." "apellidos" => "Villanueva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología. Hospital Universitario Virgen Macarena. Sevilla. España" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Reumatología. Fundación Jiménez Díaz. Madrid. España" "etiqueta" => "b" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servicio de Reumatología. Hospital Severo Ochoa. Leganés. Madrid. España" "etiqueta" => "c" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Reumatología. Hospital Nuestra Señora del Carmen. Ciudad Real. España" "etiqueta" => "d" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Servicio de Reumatología. Hospital General Universitario. Guadalajara. España" "etiqueta" => "e" "identificador" => "aff5" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondencia: Dr. F. Navarro. Servicio de Reumatología. Hospital Universitario Virgen Macarena. Av. Dr. Fedriani, 3. 41071 Sevilla. España." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy and safety of intraarticular injections of hyaluronic acid in knee osteoarthritis: clinical and ultrasonographic evaluations" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-04-27" "fechaAceptado" => "2005-10-28" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111544" "palabras" => array:3 [ 0 => "Ácido hialurónico" 1 => "Artrosis de rodilla" 2 => "Viscosuplementación" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111543" "palabras" => array:3 [ 0 => "Hyaluronic acid" 1 => "Osteoarthritis of the knee" 2 => "Viscosupplementation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "ObjetivosEvaluar la eficacia y seguridad del ácido hialurónico (AH) intraarticular en pacientes con artrosis de rodilla. Pacientes y métodosEstudio prospectivo, multicéntrico, no controlado con 6 meses de seguimiento. Se incluyó a 111 pacientes ambulatorios diagnosticados de artrosis de rodilla según criterios clínicos y radiológicos (excepto grado IV de Kellgren). A los pacientes se les administraron 5 inyecciones intraarticulares de AH (Adant®, Tedec-Meiji Farma S.A.) con cadencia semanal. La eficacia se evaluó a las 2, 12 y 24 postratamiento respecto del dolor global (EVA), índice Lequesne, índice WOMAC, valoración global por el paciente y el investigador (escala tipo Likert), rango de movimiento de flexión y extensión, y consumo de analgésicos. Se realizó ecografía de rodilla al inicio y al final del estudio. La seguridad se valoró mediante registro sistemático de acontecimientos adversos. ResultadosLos pacientes mostraron mejoría estadísticamente significativa en todos los parámetros respecto a los valores basales (p≤0,01). A los 6 meses, el 68% de los pacientes valoró su situación como mejor o mucho mejor. La presencia y cantidad de derrame sinovial en la articulación de la rodilla disminuyó de forma considerable tras el tratamiento. Los acontecimientos adversos fueron, sobre todo, locales y debidos mayoritariamente a la técnica de administración, y aparecieron reacciones por inyección en el 2,4% de los casos. ConclusiónLa administración de AH intraarticular es una alternativa eficaz y bien tolerada para el tratamiento de la artrosis de rodilla leve a moderada, con mejoría sintomática de hasta 6 meses." ] "en" => array:1 [ "resumen" => "ObjectivesTo evaluate the efficacy and safety of hyaluronic acid (HA) therapy in patients with osteoarthritis of the knee. Materials and methodsWe performed a prospective, multicenter, noncontrolled study with a 6-month followup. One hundred eleven outpatients with a diagnosis of knee osteoarthritis based on clinical and radiological criteria (except for Kellgren grade IV) were enrolled in the four participating centers. Five sequential intraarticular injections of HA (Adant®, Tedec-Meiji Farma, S.A.) were administered over a 4-week period. Efficacy was evaluated at the follow-up visits (2, 12 and 24 weeks after the final injection) by comparing posttreatment with baseline scores for the following variables: overall knee pain on a visual analog scale, Lequesne Index, WOMAC Index, patient and investigator overall assessment of efficacy on a 5-point Likert scale, knee range of movement, and analgesic consumption. Knee ultrasonography was performed at baseline and at the end of the study. Safety was evaluated by systematic recording of adverse events (AE). ResultsA statistically significant improvement in all the efficacy variables analyzed (p≤0.01) compared with baseline values was found at each of the follow-up visits. At 24 weeks, more than 68% of the patients rated their status as better or much better. The presence and amount of intraarticular fluid in the knee joint, assessed by ultrasonography, diminished dramatically after HA treatment. Most of the adverse events were local and were mainly due to the administration technique; the incidence of AEs due to injection was 2.4%. ConclusionIntraarticular administration of HA is an effective, safe and well-tolerated alternative in the treatment of mild-to-moderate osteoarthritis with symptomatic improvement lasting up to 6 months." ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for the medical management of osteoarthritis of the hip and knee. 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.D. Altman" 1 => "M.C. Hochberg" 2 => "R.W. Moskowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2000" "volumen" => "43" "paginaInicial" => "1905" "paginaFinal" => "1915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11014340" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for Testing Slow Acting Drugs in Osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Lequesne" 1 => "K. Brandt" 2 => "N. Bellamy" 3 => "R. Moskowitz" 4 => "C. Menkes" 5 => "J. Pelletier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1994" "volumen" => "21" "numero" => "Supl 41" "paginaInicial" => "65" "paginaFinal" => "73" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarticular Sodium Hyaluronate (Hyalgan®) in the treatment of Patients with Osteoarthritis of the Knee: A Randomized Clinical Trial" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Hyalgan® Study Group" "etal" => false "autores" => array:2 [ 0 => "R.D. Altman" 1 => "R.W. Moskowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1998" "volumen" => "25" "paginaInicial" => "2203" "paginaFinal" => "2212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9818665" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acción biológica del ácido hialurónico sobre los condrocitos artrósicos humanos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.J. Blanco" 1 => "E. Maneiro" 2 => "J.L. Fernández-Sueiro" 3 => "F.J. De Toro" 4 => "M. Freire" 5 => "J. Graña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Rev Esp Reumatol" "fecha" => "2000" "volumen" => "27" "paginaInicial" => "233" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influencia del peso molecular sobre los efectos biológicos del ácido hialurónico en los condrocitos articulares humanos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Maneiro" 1 => "M.J. López-Armada" 2 => "I. Fuentes" 3 => "J.L. Fernández-Sueiro" 4 => "B. Lema" 5 => "G. Graña" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Reumatol" "fecha" => "2001" "volumen" => "28" "paginaInicial" => "243" "itemHostRev" => array:3 [ "pii" => "S1575092209708423" "estado" => "S300" "issn" => "15750922" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An Analysis of Clinical Studies of the Use of Crosslinked Hyaluronan, Hylan, in the Treatament of Osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.E. Adams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1993" "volumen" => "20" "numero" => "Supl 39" "paginaInicial" => "16" "paginaFinal" => "18" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarticular Hyaluronan Injections in the Treatment of Osteoarthritis: State of the Art Review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.G. Peyron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1993" "volumen" => "20" "numero" => "Supl 39" "paginaInicial" => "10" "paginaFinal" => "15" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Villanueva I. Quality of Life in Osteoarthritis. Evaluation of physical function in knee osteoarthritis: Validation of an Spanish version of the WOMAC Questionnarie. Doctoral Thesis. University of Seville; 2001" ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemistry of normal synovium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.D. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2003.013383" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2004" "volumen" => "63" "paginaInicial" => "785" "paginaFinal" => "790" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15194572" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonographic imaging of normal and osteoarthritic cartilage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Grassi" 1 => "G. Lamanna" 2 => "A. Farina" 3 => "C. Cervicni" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "1999" "volumen" => "28" "paginaInicial" => "398" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10406407" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A method for estimating the probability of adverse drug reactions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.A. Naranjo" 1 => "V. Bustos" 2 => "E.M. Sellers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther" "fecha" => "1981" "volumen" => "30" "paginaInicial" => "239" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7249508" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A report of the Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Dougados" 1 => "P. LeClaire" 2 => "D. Van der Heijde" 3 => "D.A. Bloch" 4 => "N. Bellamy" 5 => "R.D. Altman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Osteoarthritisitis Cartilage" "fecha" => "2000" "volumen" => "8" "paginaInicial" => "395" "paginaFinal" => "403" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultrasonography in arthritis of the knee. A comparison with MR imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Ostergaard" 1 => "M. Court-Payen" 2 => "P. Gideon" 3 => "S. Wieslander" 4 => "M. Cortsen" 5 => "I. Lorenzen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Radiol" "fecha" => "1995" "volumen" => "36" "paginaInicial" => "19" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7833164" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonographic evaluation of osteoarthritic femoral condylar cartilage. Correlation with operative findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.J. McCune" 1 => "D.K. Dedrick" 2 => "A.M. Aisen" 3 => "A. MacGuire" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Orthop" "fecha" => "1990" "volumen" => "254" "paginaInicial" => "230" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2182254" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Precision of hyaline cartilage thickness measurements" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Jonsson" 1 => "K. Buckwalter" 2 => "M. Helvie" 3 => "L. Niklason" 4 => "W. Martel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Radiol" "fecha" => "1992" "volumen" => "33" "paginaInicial" => "234" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1591125" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonographic evaluation of femoral condylar cartilage in osteoarthritis and rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Iagnocco" 1 => "G. Coari" 2 => "A. Zoppini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1992" "volumen" => "21" "paginaInicial" => "201" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1529288" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Overview: new methods in imaging osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W. Martel" 1 => "R.S. Adler" 2 => "K. Chan" 3 => "L. Niklason" 4 => "M.A. Helvie" 5 => "K. Jonsson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Rheumatol Suppl" "fecha" => "1991" "volumen" => "27" "paginaInicial" => "32" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2027123" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673606686996" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations for a Core Set of Outcome Measures for Future Phase III Clinical Trials in Knee, Hip, and Hand Osteoarthritis. Consensus Development at OMERACT III" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Bellamy" 1 => "J. Kirwan" 2 => "M. Boers" 3 => "P. Brooks" 4 => "V. Strand" 5 => "P. Tugwell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "799" "paginaFinal" => "802" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9101522" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Musculoskeletal ultrasonography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Van Holsbeeck" 1 => "J.H. Introcaso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Radiol Clin North Am" "fecha" => "1992" "volumen" => "30" "paginaInicial" => "907" "paginaFinal" => "925" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1518936" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultrasound evaluation of painful rheumatoid shoulders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.M. Alasaarela" 1 => "E.L.I. Alasaarela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1994" "volumen" => "21" "paginaInicial" => "1642" "paginaFinal" => "1648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7799342" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultrasonography in Arthritis of the Knee. A comparison with MR imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Ostergaard" 1 => "M. Court-Payen" 2 => "P. Gideon" 3 => "S. Wieslander" 4 => "M. Cortsen" 5 => "I. Lorenzen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Radiol" "fecha" => "1995" "volumen" => "36" "paginaInicial" => "19" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7833164" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elbow effusion. Distribution of joint fluid with flexion and extension and imaging implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. De Maeseneer" 1 => "J.A. Jacobson" 2 => "S. Jaovisidha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Invest Radiol" "fecha" => "1998" "volumen" => "33" "paginaInicial" => "117" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9493728" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison between clinical evaluation and Ultrasonography in detecting hydrathrosis of the knee" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.P. Hauzeur" 1 => "L. Mathy" 2 => "V. De Maertelaer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "2681" "paginaFinal" => "2683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10606382" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultrasonography is Superior to Clinical Examination in the Detection and Localization of Knee Joint Effusion in Rheumatoid Arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Kane" 1 => "P.V. Balint" 2 => "R.D. Sturrock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2003" "volumen" => "30" "paginaInicial" => "966" "paginaFinal" => "971" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734890" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High molecular weight sodium hyaruonate (hyalectin) in osteoarthritis of the knee: a 1 year placebocontrolled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Dougados" 1 => "M. Nguyen" 2 => "V. Listrat" 3 => "B. Amor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Osteoarthritis Cartilage" "fecha" => "1993" "volumen" => "1" "paginaInicial" => "97" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8886085" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interaction of intraarticular hyaluronan and albumin in the attenuation of fluid drainage from joints" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Scott" 1 => "P.J. Coleman" 2 => "R.M. Mason" 3 => "J.R. Levick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200005)43:5<1175::AID-ANR28>3.0.CO;2-B" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2000" "volumen" => "43" "paginaInicial" => "1175" "paginaFinal" => "1182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10817572" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.L. Hill" 1 => "D.G. Gale" 2 => "C.E. Chaisson" 3 => "K. Skinner" 4 => "L. Kazis" 5 => "M.E. Gale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2001" "volumen" => "28" "paginaInicial" => "1330" "paginaFinal" => "1337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11409127" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution of biologically labelled hyaluronic acid injected into joints" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.N. Antonas" 1 => "J.R.E. Fraser" 2 => "K.D. Muirden" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "1973" "volumen" => "32" "paginaInicial" => "103" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4693453" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Ghosh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "1994" "volumen" => "12" "paginaInicial" => "75" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8162648" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sodium hyaluronate therapy in osteoarthritis: arguments for a potential benefial structural effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Dougados" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Semin Arthritis Rheum" "fecha" => "2000" "volumen" => "30" "numero" => "2 Supl 1" "paginaInicial" => "19" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11071578" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/1699258X/0000000200000001/v1_201305061726/S1699258X06730157/v1_201305061726/es/main.assets" "Apartado" => array:4 [ "identificador" => "17499" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000000200000001/v1_201305061726/S1699258X06730157/v1_201305061726/es/main.pdf?idApp=UINPBA00004M&text.app=https://www.reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06730157?idApp=UINPBA00004M"]

Estadísticas

Originales

Eficacia y seguridad de las inyecciones intraarticulares de ácido hialurónico en la artrosis de rodilla. Evaluación clínica y ecográfica

Efficacy and safety of intraarticular injections of hyaluronic acid in knee osteoarthritis: clinical and ultrasonographic evaluations

F. Navarroa,

Autor para correspondencia

federiconavarro@supercable.es

Correspondencia: Dr. F. Navarro. Servicio de Reumatología. Hospital Universitario Virgen Macarena. Av. Dr. Fedriani, 3. 41071 Sevilla. España.

, G. Herrero-Beaumontb, E. Naredoc, J. Paulinod, J. Torneroe, I. Villanuevaa

a Servicio de Reumatología. Hospital Universitario Virgen Macarena. Sevilla. España

b Servicio de Reumatología. Fundación Jiménez Díaz. Madrid. España

c Servicio de Reumatología. Hospital Severo Ochoa. Leganés. Madrid. España

d Servicio de Reumatología. Hospital Nuestra Señora del Carmen. Ciudad Real. España

e Servicio de Reumatología. Hospital General Universitario. Guadalajara. España

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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficacia y seguridad del &#225;cido hialur&#243;nico &#40;AH&#41; intraarticular en pacientes con artrosis de rodilla&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo&#44; multic&#233;ntrico&#44; no controlado con 6 meses de seguimiento&#46; Se incluy&#243; a 111 pacientes ambulatorios diagnosticados de artrosis de rodilla seg&#250;n criterios cl&#237;nicos y radiol&#243;gicos &#40;excepto grado IV de Kellgren&#41;&#46; A los pacientes se les administraron 5 inyecciones intraarticulares de AH &#40;Adant<span class="elsevierStyleSup">&#174;</span>&#44; Tedec-Meiji Farma S&#46;A&#46;&#41; con cadencia semanal&#46; La eficacia se evalu&#243; a las 2&#44; 12 y 24 postratamiento respecto del dolor global &#40;EVA&#41;&#44; &#237;ndice Lequesne&#44; &#237;ndice WOMAC&#44; valoraci&#243;n global por el paciente y el investigador &#40;escala tipo Likert&#41;&#44; rango de movimiento de flexi&#243;n y extensi&#243;n&#44; y consumo de analg&#233;sicos&#46; Se realiz&#243; ecograf&#237;a de rodilla al inicio y al final del estudio&#46; La seguridad se valor&#243; mediante registro sistem&#225;tico de acontecimientos adversos&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Los pacientes mostraron mejor&#237;a estad&#237;sticamente significativa en todos los par&#225;metros respecto a los valores basales &#40;p<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46; A los 6 meses&#44; el 68&#37; de los pacientes valor&#243; su situaci&#243;n como mejor o mucho mejor&#46; La presencia y cantidad de derrame sinovial en la articulaci&#243;n de la rodilla disminuy&#243; de forma considerable tras el tratamiento&#46; Los acontecimientos adversos fueron&#44; sobre todo&#44; locales y debidos mayoritariamente a la t&#233;cnica de administraci&#243;n&#44; y aparecieron reacciones por inyecci&#243;n en el 2&#44;4&#37; de los casos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n de AH intraarticular es una alternativa eficaz y bien tolerada para el tratamiento de la artrosis de rodilla leve a moderada&#44; con mejor&#237;a sintom&#225;tica de hasta 6 meses&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To evaluate the efficacy and safety of hyaluronic acid &#40;HA&#41; therapy in patients with osteoarthritis of the knee&#46;</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We performed a prospective&#44; multicenter&#44; noncontrolled study with a 6-month followup&#46; One hundred eleven outpatients with a diagnosis of knee osteoarthritis based on clinical and radiological criteria &#40;except for Kellgren grade IV&#41; were enrolled in the four participating centers&#46; Five sequential intraarticular injections of HA &#40;Adant<span class="elsevierStyleSup">&#174;</span>&#44; Tedec-Meiji Farma&#44; S&#46;A&#46;&#41; were administered over a 4-week period&#46; Efficacy was evaluated at the follow-up visits &#40;2&#44; 12 and 24 weeks after the final injection&#41; by comparing posttreatment with baseline scores for the following variables&#58; overall knee pain on a visual analog scale&#44; Lequesne Index&#44; WOMAC Index&#44; patient and investigator overall assessment of efficacy on a 5-point Likert scale&#44; knee range of movement&#44; and analgesic consumption&#46; Knee ultrasonography was performed at baseline and at the end of the study&#46; Safety was evaluated by systematic recording of adverse events &#40;AE&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A statistically significant improvement in all the efficacy variables analyzed &#40;p<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; compared with baseline values was found at each of the follow-up visits&#46; At 24 weeks&#44; more than 68&#37; of the patients rated their status as better or much better&#46; The presence and amount of intraarticular fluid in the knee joint&#44; assessed by ultrasonography&#44; diminished dramatically after HA treatment&#46; Most of the adverse events were local and were mainly due to the administration technique&#59; the incidence of AEs due to injection was 2&#46;4&#37;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Intraarticular administration of HA is an effective&#44; safe and well-tolerated alternative in the treatment of mild-to-moderate osteoarthritis with symptomatic improvement lasting up to 6 months&#46;</p>"
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                      "titulo" => "Recommendations for the medical management of osteoarthritis of the hip and knee&#46; 2000 update&#46; American College of Rheumatology Subcommittee on Osteoarthritis guidelines"
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                        "tituloSerie" => "Arthritis Rheum"
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                      "titulo" => "Guidelines for Testing Slow Acting Drugs in Osteoarthritis"
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                            2 => "N&#46; Bellamy"
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                            4 => "C&#46; Menkes"
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                        "tituloSerie" => "J Rheumatol"
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                        "volumen" => "21"
                        "numero" => "Supl 41"
                        "paginaInicial" => "65"
                        "paginaFinal" => "73"
                      ]
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                    0 => array:2 [
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                    0 => array:1 [
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                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1998"
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                        "paginaFinal" => "2212"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9818665"
                            "web" => "Medline"
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                        "tituloSerie" => "J Rheumatol"
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                        "paginaFinal" => "15"
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                    0 => array:2 [
                      "titulo" => "Immunohistochemistry of normal synovium"
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                        0 => array:2 [
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                          "autores" => array:1 [
                            0 => "M&#46;D&#46; Smith"
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                    0 => array:2 [
                      "doi" => "10.1136/ard.2003.013383"
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                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2004"
                        "volumen" => "63"
                        "paginaInicial" => "785"
                        "paginaFinal" => "790"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Sonographic imaging of normal and osteoarthritic cartilage"
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                          "autores" => array:4 [
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                            2 => "A&#46; Farina"
                            3 => "C&#46; Cervicni"
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                        ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "1999"
                        "volumen" => "28"
                        "paginaInicial" => "398"
                        "paginaFinal" => "403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10406407"
                            "web" => "Medline"
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                      "titulo" => "A method for estimating the probability of adverse drug reactions"
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                            0 => "C&#46;A&#46; Naranjo"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Pharmacol Ther"
                        "fecha" => "1981"
                        "volumen" => "30"
                        "paginaInicial" => "239"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7249508"
                            "web" => "Medline"
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                          "autores" => array:6 [
                            0 => "M&#46; Dougados"
                            1 => "P&#46; LeClaire"
                            2 => "D&#46; Van der Heijde"
                            3 => "D&#46;A&#46; Bloch"
                            4 => "N&#46; Bellamy"
                            5 => "R&#46;D&#46; Altman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Osteoarthritisitis Cartilage"
                        "fecha" => "2000"
                        "volumen" => "8"
                        "paginaInicial" => "395"
                        "paginaFinal" => "403"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasonography in arthritis of the knee&#46; A comparison with MR imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ostergaard"
                            1 => "M&#46; Court-Payen"
                            2 => "P&#46; Gideon"
                            3 => "S&#46; Wieslander"
                            4 => "M&#46; Cortsen"
                            5 => "I&#46; Lorenzen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Radiol"
                        "fecha" => "1995"
                        "volumen" => "36"
                        "paginaInicial" => "19"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7833164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sonographic evaluation of osteoarthritic femoral condylar cartilage&#46; Correlation with operative findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;J&#46; McCune"
                            1 => "D&#46;K&#46; Dedrick"
                            2 => "A&#46;M&#46; Aisen"
                            3 => "A&#46; MacGuire"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Orthop"
                        "fecha" => "1990"
                        "volumen" => "254"
                        "paginaInicial" => "230"
                        "paginaFinal" => "235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2182254"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Precision of hyaline cartilage thickness measurements"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Jonsson"
                            1 => "K&#46; Buckwalter"
                            2 => "M&#46; Helvie"
                            3 => "L&#46; Niklason"
                            4 => "W&#46; Martel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Radiol"
                        "fecha" => "1992"
                        "volumen" => "33"
                        "paginaInicial" => "234"
                        "paginaFinal" => "239"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1591125"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sonographic evaluation of femoral condylar cartilage in osteoarthritis and rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Iagnocco"
                            1 => "G&#46; Coari"
                            2 => "A&#46; Zoppini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Rheumatol"
                        "fecha" => "1992"
                        "volumen" => "21"
                        "paginaInicial" => "201"
                        "paginaFinal" => "203"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1529288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Overview&#58; new methods in imaging osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W&#46; Martel"
                            1 => "R&#46;S&#46; Adler"
                            2 => "K&#46; Chan"
                            3 => "L&#46; Niklason"
                            4 => "M&#46;A&#46; Helvie"
                            5 => "K&#46; Jonsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Rheumatol Suppl"
                        "fecha" => "1991"
                        "volumen" => "27"
                        "paginaInicial" => "32"
                        "paginaFinal" => "37"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2027123"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606686996"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommendations for a Core Set of Outcome Measures for Future Phase III Clinical Trials in Knee&#44; Hip&#44; and Hand Osteoarthritis&#46; Consensus Development at OMERACT III"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Bellamy"
                            1 => "J&#46; Kirwan"
                            2 => "M&#46; Boers"
                            3 => "P&#46; Brooks"
                            4 => "V&#46; Strand"
                            5 => "P&#46; Tugwell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1997"
                        "volumen" => "24"
                        "paginaInicial" => "799"
                        "paginaFinal" => "802"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9101522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Musculoskeletal ultrasonography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Van Holsbeeck"
                            1 => "J&#46;H&#46; Introcaso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiol Clin North Am"
                        "fecha" => "1992"
                        "volumen" => "30"
                        "paginaInicial" => "907"
                        "paginaFinal" => "925"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1518936"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasound evaluation of painful rheumatoid shoulders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;M&#46; Alasaarela"
                            1 => "E&#46;L&#46;I&#46; Alasaarela"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "21"
                        "paginaInicial" => "1642"
                        "paginaFinal" => "1648"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7799342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasonography in Arthritis of the Knee&#46; A comparison with MR imaging"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ostergaard"
                            1 => "M&#46; Court-Payen"
                            2 => "P&#46; Gideon"
                            3 => "S&#46; Wieslander"
                            4 => "M&#46; Cortsen"
                            5 => "I&#46; Lorenzen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Radiol"
                        "fecha" => "1995"
                        "volumen" => "36"
                        "paginaInicial" => "19"
                        "paginaFinal" => "26"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7833164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elbow effusion&#46; Distribution of joint fluid with flexion and extension and imaging implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; De Maeseneer"
                            1 => "J&#46;A&#46; Jacobson"
                            2 => "S&#46; Jaovisidha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Invest Radiol"
                        "fecha" => "1998"
                        "volumen" => "33"
                        "paginaInicial" => "117"
                        "paginaFinal" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9493728"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison between clinical evaluation and Ultrasonography in detecting hydrathrosis of the knee"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;P&#46; Hauzeur"
                            1 => "L&#46; Mathy"
                            2 => "V&#46; De Maertelaer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1999"
                        "volumen" => "26"
                        "paginaInicial" => "2681"
                        "paginaFinal" => "2683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10606382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrasonography is Superior to Clinical Examination in the Detection and Localization of Knee Joint Effusion in Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Kane"
                            1 => "P&#46;V&#46; Balint"
                            2 => "R&#46;D&#46; Sturrock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "966"
                        "paginaFinal" => "971"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734890"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High molecular weight sodium hyaruonate &#40;hyalectin&#41; in osteoarthritis of the knee&#58; a 1 year placebocontrolled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Dougados"
                            1 => "M&#46; Nguyen"
                            2 => "V&#46; Listrat"
                            3 => "B&#46; Amor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Osteoarthritis Cartilage"
                        "fecha" => "1993"
                        "volumen" => "1"
                        "paginaInicial" => "97"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8886085"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interaction of intraarticular hyaluronan and albumin in the attenuation of fluid drainage from joints"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Scott"
                            1 => "P&#46;J&#46; Coleman"
                            2 => "R&#46;M&#46; Mason"
                            3 => "J&#46;R&#46; Levick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200005)43:5<1175::AID-ANR28>3.0.CO;2-B"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "43"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1182"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10817572"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Knee effusions&#44; popliteal cysts&#44; and synovial thickening&#58; association with knee pain in osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Hill"
                            1 => "D&#46;G&#46; Gale"
                            2 => "C&#46;E&#46; Chaisson"
                            3 => "K&#46; Skinner"
                            4 => "L&#46; Kazis"
                            5 => "M&#46;E&#46; Gale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2001"
                        "volumen" => "28"
                        "paginaInicial" => "1330"
                        "paginaFinal" => "1337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11409127"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distribution of biologically labelled hyaluronic acid injected into joints"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;N&#46; Antonas"
                            1 => "J&#46;R&#46;E&#46; Fraser"
                            2 => "K&#46;D&#46; Muirden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "1973"
                        "volumen" => "32"
                        "paginaInicial" => "103"
                        "paginaFinal" => "111"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4693453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of hyaluronic acid &#40;hyaluronan&#41; in health and disease&#58; interactions with cells&#44; cartilage and components of synovial fluid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46; Ghosh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "12"
                        "paginaInicial" => "75"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8162648"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium hyaluronate therapy in osteoarthritis&#58; arguments for a potential benefial structural effect"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Dougados"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2000"
                        "volumen" => "30"
                        "numero" => "2 Supl 1"
                        "paginaInicial" => "19"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11071578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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  "PDF" => "https://static.elsevier.es/multimedia/1699258X/0000000200000001/v1_201305061726/S1699258X06730157/v1_201305061726/es/main.pdf?idApp=UINPBA00004M&text.app=https://www.reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X06730157?idApp=UINPBA00004M"
]

Información del artículo

ISSN: 1699258X
Idioma original: Español

DOI:10.1016/S1699-258X(06)73015-7

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año/Mes	Html	Pdf	Total

2024 Octubre	59	23	82
2024 Septiembre	180	46	226
2024 Agosto	177	72	249
2024 Julio	178	61	239
2024 Junio	209	66	275
2024 Mayo	143	65	208
2024 Abril	108	27	135
2024 Marzo	114	45	159
2024 Febrero	79	39	118
2024 Enero	94	24	118
2023 Diciembre	74	40	114
2023 Noviembre	85	42	127
2023 Octubre	132	37	169
2023 Septiembre	158	44	202
2023 Agosto	112	21	133
2023 Julio	133	43	176
2023 Junio	190	34	224
2023 Mayo	252	43	295
2023 Abril	182	14	196
2023 Marzo	287	52	339
2023 Febrero	214	46	260
2023 Enero	152	19	171
2022 Diciembre	115	46	161
2022 Noviembre	284	55	339
2022 Octubre	242	42	284
2022 Septiembre	272	46	318
2022 Agosto	234	52	286
2022 Julio	168	57	225
2022 Junio	131	64	195
2022 Mayo	136	90	226
2022 Abril	144	66	210
2022 Marzo	124	84	208
2022 Febrero	121	67	188
2022 Enero	126	73	199
2021 Diciembre	99	86	185
2021 Noviembre	139	105	244
2021 Octubre	162	74	236
2021 Septiembre	127	81	208
2021 Agosto	74	54	128
2021 Julio	87	42	129
2021 Junio	115	41	156
2021 Mayo	137	56	193
2021 Abril	450	60	510
2021 Marzo	211	44	255
2021 Febrero	141	38	179
2021 Enero	138	47	185
2020 Diciembre	133	29	162
2020 Noviembre	312	55	367
2020 Octubre	256	38	294
2020 Septiembre	215	36	251
2020 Agosto	179	50	229
2020 Julio	167	35	202
2020 Junio	218	61	279
2020 Mayo	173	53	226
2020 Abril	140	44	184
2020 Marzo	197	69	266
2020 Febrero	246	73	319
2020 Enero	271	89	360
2019 Diciembre	206	121	327
2019 Noviembre	212	108	320
2019 Octubre	324	171	495
2019 Septiembre	279	180	459
2019 Agosto	282	184	466
2019 Julio	309	162	471
2019 Junio	331	197	528
2019 Mayo	381	175	556
2019 Abril	327	264	591
2019 Marzo	294	202	496
2019 Febrero	290	163	453
2019 Enero	302	192	494
2018 Diciembre	277	124	401
2018 Noviembre	263	67	330
2018 Octubre	290	122	412
2018 Septiembre	470	158	628
2018 Agosto	531	108	639
2018 Julio	245	18	263
2018 Junio	1	0	1
2018 Mayo	20	2	22
2018 Abril	169	85	254
2018 Marzo	203	78	281
2018 Febrero	177	70	247
2018 Enero	145	53	198
2017 Diciembre	152	33	185
2017 Noviembre	209	65	274
2017 Octubre	200	54	254
2017 Septiembre	251	44	295
2017 Agosto	270	58	328
2017 Julio	208	55	263
2017 Junio	191	39	230
2017 Mayo	251	39	290
2017 Abril	395	33	428
2017 Marzo	363	43	406
2017 Febrero	557	48	605
2017 Enero	278	31	309
2016 Diciembre	255	16	271
2016 Noviembre	317	20	337
2016 Octubre	386	31	417
2016 Septiembre	491	32	523
2016 Agosto	442	20	462
2016 Julio	244	25	269
2016 Abril	1	0	1
2016 Marzo	3	0	3
2015 Diciembre	2	0	2
2015 Noviembre	3	0	3
2015 Octubre	1	0	1
2015 Agosto	3	0	3
2015 Julio	284	7	291
2015 Junio	490	17	507
2015 Mayo	498	28	526
2015 Abril	494	30	524
2015 Marzo	595	14	609
2015 Febrero	543	7	550
2015 Enero	442	18	460
2014 Diciembre	637	9	646
2014 Noviembre	762	10	772
2014 Octubre	818	16	834
2014 Septiembre	569	9	578
2014 Agosto	594	10	604
2014 Julio	657	5	662
2014 Junio	674	10	684
2014 Mayo	509	17	526
2014 Abril	310	19	329
2014 Marzo	229	22	251
2014 Febrero	171	18	189
2014 Enero	201	15	216
2013 Diciembre	157	12	169
2013 Noviembre	238	6	244
2013 Octubre	186	19	205
2013 Septiembre	130	16	146
2013 Agosto	92	22	114
2013 Julio	74	21	95
2013 Junio	60	15	75
2013 Mayo	57	16	73
2013 Abril	39	14	53
2013 Marzo	46	12	58
2013 Febrero	31	7	38
2013 Enero	26	5	31
2012 Diciembre	23	8	31
2012 Noviembre	19	6	25
2012 Octubre	12	8	20
2012 Septiembre	5	5	10
2012 Julio	1	0	1
2012 Mayo	2	0	2
2012 Marzo	1	0	1
2012 Enero	2	0	2
2011 Diciembre	2	0	2
2011 Noviembre	1	0	1
2011 Octubre	1	0	1
2011 Septiembre	1	0	1
2011 Agosto	1	0	1
2011 Julio	1	0	1
2011 Junio	3	0	3
2011 Mayo	8	0	8
2011 Abril	14	0	14
2011 Marzo	37	0	37
2011 Febrero	48	0	48
2011 Enero	62	0	62
2010 Diciembre	46	0	46
2010 Noviembre	43	0	43
2010 Octubre	25	0	25
2010 Septiembre	29	0	29
2010 Agosto	30	0	30
2010 Julio	43	0	43
2010 Junio	52	0	52
2010 Mayo	62	0	62
2010 Abril	81	0	81
2010 Marzo	64	0	64
2010 Febrero	55	0	55
2010 Enero	46	0	46
2009 Diciembre	67	0	67
2009 Noviembre	26	0	26
2009 Octubre	19	0	19
2009 Septiembre	23	0	23
2009 Agosto	24	0	24
2009 Julio	47	0	47
2009 Junio	25	0	25
2009 Mayo	24	0	24
2009 Abril	23	0	23
2009 Marzo	9	0	9
2009 Febrero	1	0	1
2008 Diciembre	35	0	35
2008 Noviembre	70	0	70
2008 Octubre	77	0	77
2008 Septiembre	80	0	80
2008 Agosto	51	0	51
2008 Julio	47	0	47
2008 Junio	54	0	54
2008 Mayo	61	0	61
2008 Abril	107	0	107
2008 Marzo	99	0	99
2008 Febrero	71	0	71
2008 Enero	86	0	86
2007 Diciembre	63	0	63
2007 Noviembre	93	0	93
2007 Octubre	99	0	99
2007 Septiembre	102	0	102
2007 Agosto	79	0	79
2007 Julio	84	0	84
2007 Junio	95	0	95
2007 Mayo	85	0	85
2007 Abril	70	0	70
2007 Marzo	80	0	80
2007 Febrero	91	0	91
2007 Enero	52	0	52

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