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Is it the same?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "345" "paginaFinal" => "346" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carlos Abud-Mendoza, Marco U. Martínez-Martínez" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Carlos" "apellidos" => "Abud-Mendoza" "email" => array:1 [ 0 => "c_abud@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Marco U." "apellidos" => "Martínez-Martínez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad Regional de Reumatología y Osteoporosis, Hospital Central “Dr. Ignacio Morones Prieto” y Facultad de Medicina de la Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Triple terapia con FARME no biológico o tratamiento biológico para artritis reumatoide. ¿Son lo mismo?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The goals for rheumatoid arthritis (RA)—remission or low disease activity— are achieved through combination therapy with disease-modifying antirheumatic drugs (DMARDs) or biologic therapy. DMARDs combination therapy achieve the goals in higher percentage than DMARD monotherapy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a>. Recently O’Dell et al. compared triple therapy with three non-biologic DMARDs, and biologic therapy with etanercept-methotrexate in RA<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>. This comparison is important for developing countries because the poor availability through social security<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">O’Dell and colleagues did not find significant differences in DAS28 (using erythrocyte sedimentation ratio, ESR or <span class="elsevierStyleSmallCaps">C</span> reactive protein, CRP). Even DAS28 is considered the “gold standard” for evaluating disease activity, other clinical measures such as ultrasound or MRI might improve sensitivity for the targets in RA patients<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5–8</span></a>. The study reported that patients receiving biologic therapy achieved American College of Rheumatology ACR50 and ACR70 almost 10% higher than triple therapy. Previous studies informed improved productivity of daily work8 and slow or not radiographic progression in patients under biologics therapy, although the significance related with the structural differences is not clinically defined<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,9,10</span></a>. It is clear that there are benefits for patients receiving biologic therapy.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical benefits of triple therapy previously mentioned are relevant in most RA patients when compared to efficacy of DMARD combination. This is especially an attractive treatment because of the lower cost of triple therapy compared to biologics, particularly in developing countries. Although we do not have official data related with social security in México, approximately 20% of RA patients covered by ISSSTE (11% of total Mexican population), and less than 5% of IMSS (59% of total Mexican population) are receiving a biological therapy; Mexican population with no social security is a rare event to prescribe biologic therapy. However, although triple therapy can be more accessible than biologics, the latter treatment becomes necessary for at least in 20-30% of RA patients particularly when individual treatment is refractory to methotrexate. Nonetheless, treatments with higher doses of methotrexate<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a>, in combination with prednisone<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> or with another combination of DMARD, reduces the percentage of patients requiring biologics therapy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,14,15</span></a>. We suggest that initial triple DMARDs therapy for RA as the first therapy for monotherapy non-responsive patients and biologics must be reserved for refractory triple DMARDs therapy.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless of initial infliximab. The 5-year follow-up results of a randomised clinical trial, the NEO-RACo trial" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "for the NEO-RACo Study Group" "etal" => true "autores" => array:6 [ 0 => "V. Rantalaiho" 1 => "H. 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año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 14 | 17 | 31 |
2024 Septiembre | 43 | 21 | 64 |
2024 Agosto | 79 | 30 | 109 |
2024 Julio | 66 | 31 | 97 |
2024 Junio | 64 | 22 | 86 |
2024 Mayo | 75 | 27 | 102 |
2024 Abril | 61 | 20 | 81 |
2024 Marzo | 46 | 30 | 76 |
2024 Febrero | 44 | 21 | 65 |
2024 Enero | 34 | 30 | 64 |
2023 Diciembre | 30 | 21 | 51 |
2023 Noviembre | 45 | 40 | 85 |
2023 Octubre | 62 | 44 | 106 |
2023 Septiembre | 71 | 39 | 110 |
2023 Agosto | 30 | 11 | 41 |
2023 Julio | 40 | 30 | 70 |
2023 Junio | 48 | 23 | 71 |
2023 Mayo | 36 | 22 | 58 |
2023 Abril | 16 | 13 | 29 |
2023 Marzo | 52 | 32 | 84 |
2023 Febrero | 42 | 26 | 68 |
2023 Enero | 28 | 21 | 49 |
2022 Diciembre | 37 | 27 | 64 |
2022 Noviembre | 50 | 28 | 78 |
2022 Octubre | 54 | 32 | 86 |
2022 Septiembre | 43 | 34 | 77 |
2022 Agosto | 54 | 40 | 94 |
2022 Julio | 41 | 34 | 75 |
2022 Junio | 32 | 32 | 64 |
2022 Mayo | 43 | 50 | 93 |
2022 Abril | 56 | 43 | 99 |
2022 Marzo | 53 | 56 | 109 |
2022 Febrero | 52 | 26 | 78 |
2022 Enero | 44 | 28 | 72 |
2021 Diciembre | 44 | 51 | 95 |
2021 Noviembre | 56 | 46 | 102 |
2021 Octubre | 56 | 49 | 105 |
2021 Septiembre | 47 | 44 | 91 |
2021 Agosto | 31 | 46 | 77 |
2021 Julio | 29 | 43 | 72 |
2021 Junio | 41 | 30 | 71 |
2021 Mayo | 45 | 37 | 82 |
2021 Abril | 162 | 110 | 272 |
2021 Marzo | 110 | 42 | 152 |
2021 Febrero | 85 | 26 | 111 |
2021 Enero | 67 | 27 | 94 |
2020 Diciembre | 51 | 18 | 69 |
2020 Noviembre | 64 | 14 | 78 |
2020 Octubre | 52 | 11 | 63 |
2020 Septiembre | 56 | 57 | 113 |
2020 Agosto | 57 | 35 | 92 |
2020 Julio | 42 | 19 | 61 |
2020 Junio | 54 | 16 | 70 |
2020 Mayo | 61 | 20 | 81 |
2020 Abril | 67 | 21 | 88 |
2020 Marzo | 54 | 21 | 75 |
2020 Febrero | 68 | 36 | 104 |
2020 Enero | 57 | 33 | 90 |
2019 Diciembre | 54 | 26 | 80 |
2019 Noviembre | 53 | 36 | 89 |
2019 Octubre | 48 | 33 | 81 |
2019 Septiembre | 63 | 50 | 113 |
2019 Agosto | 42 | 31 | 73 |
2019 Julio | 50 | 37 | 87 |
2019 Junio | 82 | 27 | 109 |
2019 Mayo | 66 | 68 | 134 |
2019 Abril | 57 | 38 | 95 |
2019 Marzo | 42 | 18 | 60 |
2019 Febrero | 38 | 18 | 56 |
2019 Enero | 29 | 29 | 58 |
2018 Diciembre | 64 | 58 | 122 |
2018 Noviembre | 72 | 23 | 95 |
2018 Octubre | 51 | 22 | 73 |
2018 Septiembre | 33 | 6 | 39 |
2018 Agosto | 28 | 8 | 36 |
2018 Julio | 17 | 6 | 23 |
2018 Mayo | 2 | 0 | 2 |
2018 Abril | 36 | 6 | 42 |
2018 Marzo | 60 | 5 | 65 |
2018 Febrero | 18 | 3 | 21 |
2018 Enero | 18 | 2 | 20 |
2017 Diciembre | 19 | 8 | 27 |
2017 Noviembre | 20 | 5 | 25 |
2017 Octubre | 25 | 8 | 33 |
2017 Septiembre | 23 | 16 | 39 |
2017 Agosto | 17 | 9 | 26 |
2017 Julio | 27 | 11 | 38 |
2017 Junio | 38 | 5 | 43 |
2017 Mayo | 35 | 10 | 45 |
2017 Abril | 39 | 6 | 45 |
2017 Marzo | 32 | 9 | 41 |
2017 Febrero | 16 | 4 | 20 |
2017 Enero | 26 | 7 | 33 |
2016 Diciembre | 53 | 21 | 74 |
2016 Noviembre | 36 | 10 | 46 |
2016 Octubre | 56 | 16 | 72 |
2016 Septiembre | 39 | 6 | 45 |
2016 Agosto | 53 | 13 | 66 |
2016 Julio | 38 | 8 | 46 |
2016 Junio | 1 | 0 | 1 |
2016 Abril | 1 | 0 | 1 |
2016 Marzo | 2 | 0 | 2 |
2016 Febrero | 1 | 0 | 1 |
2015 Diciembre | 2 | 0 | 2 |
2015 Noviembre | 2 | 0 | 2 |
2015 Septiembre | 2 | 0 | 2 |
2015 Agosto | 1 | 0 | 1 |
2015 Julio | 14 | 6 | 20 |
2015 Junio | 36 | 8 | 44 |
2015 Mayo | 53 | 20 | 73 |
2015 Abril | 44 | 17 | 61 |
2015 Marzo | 52 | 13 | 65 |
2015 Febrero | 44 | 16 | 60 |
2015 Enero | 61 | 19 | 80 |
2014 Diciembre | 55 | 10 | 65 |
2014 Noviembre | 51 | 17 | 68 |
2014 Octubre | 109 | 43 | 152 |
2014 Septiembre | 128 | 57 | 185 |
2014 Agosto | 49 | 26 | 75 |