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Vol. 2. Núm. 1.
Páginas 31-35 (enero - febrero 2006)
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Vol. 2. Núm. 1.
Páginas 31-35 (enero - febrero 2006)
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La entesis como elemento diana en las espondiloartritis
Enthesis as a target element in spondylarthritides
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J.L. Fernández-Sueiro
Autor para correspondencia
L.sueiro@canalejo.org

Correspondencia: Dr. J.L. Fernández-Sueiro. Servicio de Reumatología. Hospital Universitario Juan Canalejo. Las Jubias, 84. 15006 La Coruña. España.
Servicio de Reumatología. Hospital Universitario Juan Canalejo. La Coruña. España
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La entesis es una estructura frecuentemente afectada en las espondiloartritis; recientemente se ha postulado que desempeña un papel clave en la patogenia de estas enfermedades. A lo largo de esta revisión se tratarán los aspectos más relevantes de los conocimientos actuales sobre la entesis, se revisarán su anatomía y los componentes de la matriz extracelular presentes en ésta. Además se tendrá en cuenta su evaluación clínica y las técnicas modernas de imagen (resonancia magnética nuclear y ultrasonidos) que complementan su evaluación. Los estudios inmunohistológicos acompañados de los modelos animales, desarrollados con componentes de la entesis, indican su importancia en la patogenia de las espondiloartritis. Finalmente, se revisarán los últimos trabajos que evalúan la respuesta de las células T en pacientes con espondilitis anquilosante a componentes de la entesis.

Palabras clave:
Espondiloartritis
Espondilitis anquilosante
Entesis
Fibrocartílago
Agrecano
Versicano

Enthesis is a structure frequently involved in spondyloarthritides. According to a recent hypothesis, it may play a key role in the pathogenesis of these entities. The present review discusses the most important aspects of current knowledge of enthesis, such as its anatomy and the extracellular matrix components present within it. Clinical evaluation and the new imaging techniques (magnetic resonance imaging and ultrasound) that complement its evaluation will be briefly described. Immunohistological studies as well as animal models developed with enthesis molecules underline the importance of enthesis in the pathogenesis of spondyloarthritides. Finally, the latest research assessing the T cell response to enthesis components in patients with ankylosing spondylitis will be reviewed.

Key words:
Spondyloarthritis
Ankylosing spondylitis
Enthesis
Fibrocartilage
Aggrecan
Versican
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Copyright © 2006. Elsevier España S.L. Barcelona
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