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Vol. 9. Issue 4.
Pages 248-249 (July - August 2013)
Vol. 9. Issue 4.
Pages 248-249 (July - August 2013)
Images in Clinical Rheumatology
DOI: 10.1016/j.reumae.2012.11.002
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Hypertrophic Osteoarthropathy Associated to Liver Cirrhosis
Osteoartropatía hipertrófica asociada a cirrosis hepática
Luz María Morána,??
Corresponding author

Corresponding author.
, Alfonso Arizab
a Servicio de Radiodiagnóstico, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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The patient, a 45-year-old male, was referred to the rheumatology clinic due to diffuse joint pain on the wrists and knees. The patient was diagnosed with liver cirrhosis and severe hepatopulmonary syndrome. Physical examination showed swelling of the knees and wrists (arthritis) and clubbing. The X-rays requested showed periosteal thickening observed continuously, in a diaphysometaphysiary location of the radius and ulna in both forearms, and predominantly in distal femurs and both knees, compatible with nonaggressive periosteal reaction. Fig. 1 shows periosteal thickening affecting both femurs on the concave bone edge and respecting the epiphysis, and equal involvement of the radius and ulna on the right wrist, in Fig. 2.

Fig. 1.

Periosteal thickening of both femurs.

Fig. 2.

Ulna and radius affection.


The findings on physical examination were finger-clubbing and arthritis of the hands and knees, and the radiological presence of continuous noninvasive periostitis of the concave edge affecting the long bones of both the upper and lower extremities, with a diagnosis of hypertrophic osteoarthropathy. This clinical entity is mainly associated with intrathoracic processes (especially malignancy, namely lung cancer and pleural tumors), but also other diseases among which one can include liver disease (hepatocellular carcinoma, alcoholic hepatitis and both Portal biliary cirrhosis and cirrhosis of the liver).1–3

In our case, the patient was treated with chemoembolization of the hepatocellular carcinoma, and is currently in alcohol detoxification using anti-inflammatory drugs for osteoarticular involvement.

Ethical Considerations

Protection of persons and animals. No experiments were performed on humans or animals.Data confidentiality. Patient data does not appear in this article.Right to privacy and informed consent. Authors obtained informed consent from patients and/or subjects referred to in this paper. These are in the hands of the corresponding author.


The authors have no disclosures to make.

M. Martínez-Lavín, C. Pineda.
Contribuciones de la Reumatología Mexicana al conocimiento médico. Osteoartropatía hipertrófica.
Rev Mex Reumatol, 16 (2001), pp. 223-226
M. Martinez-Lavin, A. Vargas, M. Rivera-Viñas.
Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation.
Curr Opin Rheumatol, 20 (2008), pp. 88-91
N. Gómez Rodríguez, J. Ibáñez Ruán, M. González Pérez.
Osteoartropatía hipertrófica primaria (paquidermoperiostosis). Aportación de 2 casos familiares y revisión de la literatura.
Rheumatol Clin, 5 (2009), pp. 259-263

Please, cite this article as: Morán LM, Ariza A. Osteoartropatía hipertrófica asociada a cirrosis hepática. Reumatol Clin. 2013;9:248–9.

Copyright © 2012. Elsevier España, S.L.. All rights reserved
Reumatología Clínica (English Edition)

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