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Vol. 17. Issue 7.
Pages 397-403 (August - September 2021)
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Vol. 17. Issue 7.
Pages 397-403 (August - September 2021)
Original Article
Results from a cross-sectional, observational study to assess inadequate pain relief in patients with knee and/or hip osteoarthritis in Mexico
Resultados de un estudio transversal y observacional para valorar el alivio inadecuado del dolor en pacientes de osteoartritis de rodilla y/o cadera en México
Ruben Burgos-Vargasa, Jyoti Aggarwale, Kelly D. Johnsonb,
Corresponding author

Corresponding author.
, Dena Rameyb, Fidel Lozanoc, Cynthia Macahiligd, Ishita Doshib, Kaan Tuncelib
a Hospital General de Mexico, Department of Rheumatology, Mexico
b Merck Sharp & Dohme Corp., Center for Observational and Real World Evidence, Kenilworth, NJ, USA
c Merck Sharpe & Dohme Corp., Global Medical Affairs, Kenilworth, NJ, USA
d Medical Data Analytics (MDA), A Division of Market Certitude, LLC, USA
e Pharmerit International, USA
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Tables (4)
Table 1. Participating physicians characteristics.
Table 2. Patient demographic and clinical characteristics.
Table 3. EQ-5D descriptive results for patients with and without IPR.
Table 4. Multivariate models to assess impact of IPR on PRO outcomes.
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Introduction and objectives

There is limited data that characterizes osteoarthritis (OA) patients who experience moderate to severe pain despite analgesic treatment in Mexico. In this study, we estimate the real-world prevalence of inadequate pain relief (IPR) among individuals with knee and/or hip OA who have been prescribed analgesic therapy and characterize this patient population for each country separately.

Materials and methods

This is a multinational, multi-site, cross-sectional, observational study. Participating physicians enrolled patients over 50 years of age with diagnosed knee and/or hip OA who had been prescribed topical and/or oral pain medication for at least 30 days prior to study visit, extracted data from their medical charts, and collected patient data using established questionnaires.


301 patients treated by 35 physicians in Mexico were enrolled in the study. More than half of the patients (53%) met the definition of IPR. Patients with IPR were significantly older (66.8 vs. 63.5 years, p=0.002) and were more likely to be obese (24.2% vs. 11.9%, p=0.006). Patients in the IPR group were more likely to report moderate/severe problems across all 5 dimensions of the EQ-5D and reported higher scores, indicating worse outcomes, on all three WOMAC subscales. Patients in the IPR group also reported reduced work productivity and greater treatment dissatisfaction compared to patients without IPR.

Discussion and conclusions

IPR is highly prevalent among individuals with knee and/or hip OA in Mexico. Patients with IPR experience decreased health-related quality of life HRQoL and work productivity, impaired function, and poor treatment satisfaction. Health care professionals need to be aware of the high prevalence of IPR, work toward improving OA patient management, and facilitate early intervention or changes in drug and other treatment modalities.

Quality of life
Introducción y objetivos

Existen datos limitados que caractericen a los pacientes de osteoartritis (OA) que experimentan dolor de moderado a severo a pesar del tratamiento analgésico en México. En este estudio calculamos la prevalencia en el mundo real del alivio inadecuado del dolor (AID) entre individuos con OA de rodilla y/o cadera a quienes se ha prescrito terapia analgésica, y caracterizamos a esta población de pacientes por país, de manera separada.

Materiales y métodos

Este estudio es multinacional, multicéntrico, transversal y observacional. Los médicos participantes reclutaron a pacientes mayores de 50años, con diagnóstico de OA de rodilla y/o cadera, a quienes se había prescrito medicación analgésica tópica y/u oral durante al menos 30días previos a la visita del estudio. Dichos facultativos extrajeron datos de sus cuadros médicos y recopilaron los datos de los pacientes utilizando cuestionarios establecidos.


Se incluyó en el estudio a 301 pacientes tratados por 35 facultativos en México. Más de la mitad de los pacientes (53%) cumplió la definición de AID. Los pacientes con AID eran significativamente mayores (66,8 vs. 63,5años, p=0,002) y con mayor probabilidad de ser obesos (24,2% vs. 11,9%, p=0,006). Los pacientes del grupo AID tenían mayor probabilidad de reportar problemas moderados/severos en las 5 dimensiones de EQ-5D, y reportaron puntuaciones más altas, lo cual es indicativo de peores resultados, en las tres subescalas de WOMAC. Los pacientes del grupo AID reportaron también una reducción de la productividad laboral y mayor insatisfacción con el tratamiento, en comparación con los pacientes sin AID.

Discusión y conclusiones

El AID es altamente prevalente entre los individuos con OA de rodilla y/o cadera en México. Los pacientes con AID experimentan una disminución de la calidad de vida relacionada con la salud (HRQoL) y la productividad laboral, deterioro funcional y mala satisfacción con el tratamiento. Los profesionales sanitarios deben ser conscientes de la alta prevalencia de AID, colaborar en la mejora del tratamiento de los pacientes de OA y facilitar la intervención temprana o los cambios de las modalidades de tratamiento farmacológico o de otro tipo.

Palabras clave:
Calidad de vida


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