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Vol. 1. Núm. S2.
Novedades terapéuticas en reumatología+J1:J72
Páginas S8-S15 (Diciembre 2005)
Novedades terapéuticas en reumatología
Acceso a texto completo
Enfoque terapéutico actual de la osteoartritis
R. Espinoza-Morales
Autor para correspondencia

Correspondencia: Dr. R. Espinoza-Morales. Jefe del Departamento de Reumatología. Centro Nacional de Rehabilitación. Avda. México-Xochimilco, 289. Colonia Arenal de Guadalupe. 14389 Deleg. Tlalpan. México DF. México.
, M.E. Pérez-Bastidas
Departamento de Reumatología. Centro Nacional de Rehabilitación. México DF. México
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R. Moskowitz.
Osteoarthritis. Diagnosis and medical/surgical management.
3re ed., Sunders, (2001),
R. Loeser, N. Shakoor.
Aging or osteoarthritis: which is the problem?.
Rheum Dis Clin N Am, 29 (2003), pp. 653-673
A. Mannoni, M.P. Briganti, M. Di Bari, L. Ferrucci, S. Costanzo.
Epidemiological profile of symptomatic osteoarthritis in older adults: a population based study in Dicomano, Italy.
Ann Rheum Dis, 62 (2003), pp. 576-578
Y. Zhang, J. Niu, M. Kelly-Hayes, C.E. Chaisson, P. Aliabadi, D.T. Felson.
Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study.
Am J Epidemiol, 156 (2002), pp. 1021-1027
M.C. Nevitt, L. Xu, Y. Zhang, L.Y. Lui, W. Yu, N.E. Lane, et al.
Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study.
Arthritis Rheum, 46 (2002), pp. 1773-1779
D.T. Felson, M.C. Nevitt, Y. Zhang, P. Aliabadi, B. Baumer, D. Gale, et al.
High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects.
Arthritis Rheum, 46 (2002), pp. 1217-1222
R. Espinosa, L. Hernández, C. Arroyo.
Prevalencia de manifestaciones musculoesqueléticas en México.
Rev Mex Reumatol, 20 (2005), pp. 5
M.H. Cardiel, J. Rojas-Serrano.
Community based study to estimate prevalence, burden of illness and help seeking behavior in rheumatic diseases in Mexico City. A COPCORD study.
Clin Exp Rheumatol, 20 (2002), pp. 617-624
R. Altman, G. Alarcón, D. Appelrouth, D. Bloch, D. Boreinstein, K. Brandt, et al.
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand.
Arthritis Rheum, 33 (1990), pp. 601-610
R. Altman, G. Alarcón, D. Appelrouth, D. Bloch, D. Boreinstein, K. Brandt, et al.
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.
Arthritis Rheum, 34 (1991), pp. 505-514
R. Altman, E. Asch, D. Bloch, G. Bole, D. Boreinstein, K. Brandt, et al.
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the knee.
Arthritis Rheum, 29 (1986), pp. 1039-1049
J. Woo, E. Lau, C.H. Sing, P. Lee, J. Zhang, T. Kwok, et al.
Socioeconomic impact of osteoarthritis in Hong Kong: utilization of health and social services, and direct and indirect costs.
Arthritis Care Res, 49 (2003), pp. 526-534
L. Carmona, J. Ballina, R. Gabriel, A. Laffon, EPISER Study Group.
The burden of musculoskeletal diseases in the general population of Spain: results from a national survey.
Ann Rheum Dis, 60 (2001), pp. 1040-1045
R. Espinosa, L. Hernández, C. Arroyo.
Patrón de utilización de servicios de salud en México en pacientes con artritis.
Rev Mex Reumatol, 20 (2005), pp. 20-21
S. Bollen.
Epidemiology of knee injuries: diagnosis and triage.
Br J Sports Med, 34 (2000), pp. 227-228
J.E. Manson, S.S. Bassuk.
Obesity in the United States: a fresh look at its high toll.
JAMA, 289 (2003), pp. 229-230
C.L. Hill, S.G. Suk, D. Gale, S. Totterman, M.E. Gale, D.T. Felson.
Cruciate ligament integrity in osteoarthritis of the knee.
Arthritis Rheum, 52 (2005), pp. 794-799
M. Reijman, J.M.W. Hazes, H.A.P. Pols, B.W. Koes, S.M.A. Bierma-Zeinstra.
Acetabular dysplasia predicts incident osteoarthritis of the hip: the Rotterdam study.
Arthritis Rheum, 52 (2005), pp. 787-793
D.T. Felson.
Risk factors for osteoarthritis: understanding joint vulnerability.
Clin Orthop Relat Res, 427 (2004), pp. 16-21
D.T. Felson.
Preventing knee and hip osteoarthritis.
Bull Rheum Dis, 47 (1998), pp. 1-4
C. Slemenda, K.D. Brandt, D.K. Heilman, S. Mazzuca, E.M. Braunstein, B.P. Katz, et al.
Quadriceps weakness and osteoarthritis of the knee.
Ann Intern Med, 127 (1997), pp. 97-104
E. Superio-Cabuslay, M.M. Ward, K.R. Loring.
Patient education interventions in osteoarthritis and rheumatoid arthritis: a meta-analytic comparison with nonsteroidal antiinflammatory dug treatment.
Arthritis Care Res, 9 (1996), pp. 292-301
S.A. Mazzuca, K.D. Brandt, B.P. Katz, M.P. Hanna, C.A. Mefi.
Reduced utilization and cost of primary care clinic visits resulting from self-care education for patients with osteoarthritis of the knee.
S.A. Mazzuca, K.D. Brandt, B.P. Katz, M. Chambers, D. Byrd, M. Hanna.
Effects of self-care education on the health status of inner-city patients with osteoarthritis of the knee.
M. Weinberger, V.W. Tierney, P. Booher, B.P. Katz.
Can the provision of information to patients with osteoarthritis improve functional status? A randomized, controlled trial.
Arthritis Rheum, 32 (1989), pp. 1577-1583
D.T. Felson, J.J. Anderson, A. Naimark, A.M. Walker, R.F. Melnan.
Obesity and knee osteoarthritis.
Ann Intern Med, 109 (1988), pp. 18-24
D.T. Felson, Y. Zhang, M.T. Hannan, J.J. Anderson.
Risk factors for incident radiographic knee osteoarthritis in the elderly.
S. Tepper, M.C. Hochberg.
Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES I).
Am J Epidemiol, 137 (1993), pp. 1081-1088
W.J. Carman, M. Sowers, V.M. Hawthorne, L.A. Weissfeld.
Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study.
Am Med J Epidemiol, 139 (1994), pp. 119-129
D.T. Felson, Y. Zhang, J.M. Anthony, A. Naimark, J.J. Anderson.
Weigth loss reduces the risk of symptomatic knee osteoarthritis in women.
Ann Intern Med, 116 (1992), pp. 535-539
E. Roddy, W. Zhang, M. Doherty.
Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review.
Ann Rheum Dis, 64 (2005), pp. 544-548
S.A. Brand, R.D. Crowninshield.
The effect of cane use on hip contact force.
Clin Orthop, 147 (1980), pp. 181-184
E.M. Keating, P.M. Faris, M.A. Ritter, J. Kane.
Use of lateral heel and sole wedges in the treatment of medial osteoarthritis of the knee.
Orthop Rev, 22 (1993), pp. 921-924
R. Marks, A.H. Quinney, J. Wessel.
Reliability and validity of measurement of position sense in women with osteoarthritis of the knee.
J Rheumatol, 20 (1993), pp. 1919-1924
J. Cushnagan, C. MacCarthry, P.A. Dieppe.
Taping the patella medially: a new treatment for osteoarthritis of the knee joint?.
Br Med J, 308 (1988), pp. 753-755
W.Y. Zhang, A. Li-Wan-Po.
The effectiveness of topically applied capsaicin. A meta-analysis.
Eur J Clin Pharmacol, 46 (1994), pp. 517-522
Lin J, Zhang W, Jones A, Doherty M. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomized controlled trials. BMJ.
K.M. Jordan, N.K. Arden, M. Doherty, B. Bannwarth, J.W. Bijlsma, P. Dieppe, et al.
EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT).
Ann Rheum Dis, 62 (2003), pp. 1145-1155
American College of Rheumatology.
Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines.
W. Zhang, A. Jones, M. Doherty.
Does paracetamol (acetaminophen) reduces the pain of osteoarthritis? A meta-analysis of randomized placebo controlled trials.
Ann Rheum Dis, 63 (2004), pp. 901-907
P. Amadio, D.M. Cummings.
Evaluation of acetaminophen in the management of osteoarthritis of the knee.
Curr Ther Res, 34 (1983), pp. 59-66
M. Zoppi, G. Peretti, E. Boccard.
Placebo-controlled study of the analgesic efficacy of an effervescent formulation of 500 mg paracetamol in arthritis of the knee or hip.
Eur J Pain, 16 (1995), pp. 42-48
C. Miceli-Richard, M. Le Bars, N. Schmidely, M. Dougados.
Paracetamol in osteoarthritis of the knee.
Ann Rheum Dis, 63 (2004), pp. 923-930
T. Pincus, G. Koch, H. Lei, B. Mangal, T. Sokka, R. Moskowitz, et al.
Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomized, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis.
Ann Rheum Dis, 63 (2004), pp. 931-939
R. Neame, W. Zhang, M. Doherty.
Historic issue of the annals: three papers examines paracetamol in osteoarthritis.
Ann Rheum Dis, 63 (2004), pp. 897-900
T. Pincus, J.F. Fort, B. Mangal, G. Koch, F. Wolfe, R. Moskowitz, et al.
Patient Preference for Placebo, Acetaminophen (paracetamol), or Celebrex Effectiveness Study (PACES-1): a double-blinded, randomized, crossover clinical trial in patients with osteoarthritis of the hip or knee [resumen].
Ann Rheum Dis, 62 (2003), pp. 73
H.J. Williams, J.R. Ward, M.J. Egger, R. Neuner, R.H. Brooks, D.O. Clegg, et al.
Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee.
Arthritis Rheum, 36 (1993), pp. 1196-1206
J.D. Bradley, K.D. Brandt, B.P. Katz, L.A. Kalasinski, S.I. Ryan.
Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.
J Rheumatol, 19 (1992), pp. 1950-1954
T. Pincus, G.G. Koch, T. Sokka.
A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee.
G.P. Geba, A.L. Weaver, A.B. Polis, M.E. Dixon, T.J. Scnitzer, Vioxx ACT (VACT) Group. Vioxx ACT (VACT) Group.
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
JAMA, 287 (2002), pp. 64-71
T.J. Schnitzer, M. Kamin, W.H. Olson.
Tramadol allows reduction of naproxen dose among patientes with naproxen-responsive osteoarthritis pain.
W.S. Mullican, J.R. Lacy.
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the managament of chronic pain: a comparative trail.
Clin Ther, 23 (2001), pp. 1429-1445
J.P. Case, A.J. Baliunas, J.A. Block.
Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium.
Arch Intern Med, 163 (2003), pp. 169-178
J.A. Chard, D.J. Tallon, P.A. Dieppe.
Epidemiology of research into interventions for the treatment of osteoarthritis of the knee joint.
Ann Rheum Dis, 59 (2000), pp. 414-418
M.r. Tramer, R.A. Moore, D.J. Reyanolds, H.J. McQuay.
Quantitative estimation of rare adverse events which follow biological progression: a new model applied to chronic NSAID use.
Pain, 85 (2000), pp. 169-182
A.G. Johnson, NSDAIDs and increased blood pressure.
What is the clinical significance?.
Drug Saf, 17 (1997), pp. 277-289
G.S. Bleumink, J. Feenstra, M.C. Sturkenboom, B.H. Stricker.
Nonsteroidal anti-inflammatory drugs and heart failure.
Drugs, 63 (2003), pp. 525-534
A. Whelton.
Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications.
Am J Med, 106 (1999), pp. 13-24
P. Courtney, M. Doherty.
Key questions concerning paracetamol and NSAIDs for osteoarthritis.
Ann Rheum Dis, 61 (2002), pp. 767-773
K.D. Brandt.
Non-surgical treatment of osteoarthritis: a half century of “advances”.
Ann Rheum Dis, 63 (2004), pp. 117-122
J.M. Bjordal, A.E. Ljunggren, A. Klovning, L. Slørdal.
Non-steroidal antiinflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomized placebo controlled trials.
BMJ, 329 (2004),
F.E. Silverstein, D.Y. Graham, J.R. Senior, H.W. Davies, B.J. Struthers, R.M. Bittman, et al.
Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving non steroidal antiinflammatory drugs. A randomized, double-blind, placebo-controlled trial.
Ann Intern Med, 123 (1995), pp. 241-249
N.D. Yeomans, Z. Tulassay, L. Juhasz, I. Racz, J.M. Howard, C.J. Van Rensburg, et al.
A comparison of omeprazole with ranitidine for ulcers associated with non-steroidal anti-inflammatory drugs.
N Engl J Med, 338 (1998), pp. 719-726
F.E. Silverstein, G. Faich, J.L. Goldstein, L.S. Simon, T. Pincus.
Gastrointestinal toxicity with celecoxib vs. nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
JAMA, 284 (2000), pp. 1247-1255
C. Bombardier, L. Laine, A. Reicin, D. Shapiro, R. Burgos-Vargas.
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.
N Engl J Med, 343 (2000), pp. 1520-1528
T.D. Warner, F. Giuliano, I. Vojnovic, A. Bukasa, J.A. Mitchell, J.R. Vane.
Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclooxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
Proc Natl Acad Sci U S A, 96 (1999), pp. 7563-7568
C. Fenton, G.M. Keating, A.J. Wagstaff.
Valdecoxib: a review of its use in the management of osteoarthritis, rheumatoid arthritis, dysmenorrhoea and acute pain.
Drugs, 64 (2004), pp. 1231-1261
J.E. Edwards, H.J. McQuay, R.A. Moore.
Efficacy and safety of valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials.
K.A. Lyseng-Williamson, M.P. Curran.
Drugs, 64 (2004), pp. 2237-2246
C.C. Hawkey, P. Svoboda, I.F. Fiedorowicz-Fabrycy, E.L. Nasonov, E.G. Pikhlak, M. Cousin, et al.
Gastroduodenal safety and tolerability of lumiracoxib compared with ibuprofen and celecoxib in patients with osteoarthritis.
J Rheumatol, 31 (2004), pp. 1804-1810
Food and Drugs Administration. Disponible en:
R.S. Bresalier, R.S. Sandler, H. Quan, J.A. Bolognese, B. Oxenius, K. Horgan, Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators, et al.
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.
N Engl J Med, 352 (2005), pp. 1092-1102
D.J. Graham, D. Campen, R. Hui, M. Spence, C. Cheetham, G. Levy, et al.
Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study.
N.A. Nussmeier, A.A. Whelton, M.T. Brown, R.M. Langford, A. Hoeft, J.L. Parlow, et al.
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.
N Engl J Med, 352 (2005), pp. 1081-1091
S.R. Knowles, E.J. Phillips, G. Wong, N.H. Shear.
Serious dermatologic reaction associated with valdecoxib: report of two cases.
J Am Acad Dermatol, 51 (2004), pp. 1028-1029
W. Zhang, M. Doherty, N. Arden, B. Bannwarth, J. Bijlsma, K.P. Gunther, et al.
EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).
Ann Rheum Dis, 63 (2004), pp. 11-14
J.Y. Reginster, R. Leroisy, L.C. Rovati.
Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled clinical trial.
K. Pavelka, J. Gatterova, M. Olejarova, S. Machacek, G. Giacovelli, L.C. Rovati.
Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
Arch Intern Med, 162 (2002), pp. 2113-2123
F. Richy, O. Bruyere, O. Ethgen, M. Cucherat, Y. Henrotin, J.Y. Reginster.
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
Arch Intern Med, 163 (2003), pp. 1514-1522
T.E. McAlindon, M.P. LaValley, J.P. Gulin, D.T. Felson.
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
JAMA, 283 (2000), pp. 1469-1475
B.A. Michel, G. Stucki, D. Frey, F. De Vathaire, E. Vignon, P. Bruehlmann, et al.
Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial.
Arthritis Rheum, 52 (2005), pp. 779-786
M. Yaron, I. Shirazi, I. Yaron.
Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures.
Osteoarthritis Cartilage, 7 (1999), pp. 272-280
N. Felisaz, K. Boumediene, C. Ghayor, J.F. Herrouin, P. Bogdanowicz, et al.
Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1.
Osteoarthritis Cartilage, 7 (1999), pp. 255-264
J.P. Pelletier, M. Yaron, B. Haraoui, P. Cohen, M.A. Nahir, D. Choquette, et al.
Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.
M. Dougados, M. Nguyen, L. Berdah, B. Mazieres, E. Vignon, M. Lequesne.
Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the chondromodulating effect of diacerein in OA of the hip.
Arthritis Rheum, 44 (2001), pp. 2539-2547
T. Appelboom, J. Schuermans, G. Verbruggen, Y. Henrotin, J.Y. Reginster.
Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study.
Scand J Rheumatol, 30 (2001), pp. 242-247
M. Lequesne, E. Maheu, C. Cadet, R.L. Dreiser.
Structural effect of avocado/ soybean unsaponifiables on joint space loss in osteoarthritis of the hip.
Arthritis Rheum, 47 (2002), pp. 50-58
Y.E. Henrotin, C. Sánchez, M.A. Deberg, N. Piccardi, G.B. Guillou, P. Msika, et al.
Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and pro-inflammatory mediator production by human osteoarthritic chondrocytes.
J Rheumatol, 30 (2003), pp. 1825-1834
C. Kut-Lasserre, C.C. Miller, A.L. Ejeil, B. Gogly, M. Dridi, N. Piccardi, et al.
Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP-1 and TIMP-2) secretion by human fibroblasts in culture.
J Periodontol, 72 (2001), pp. 1685-1694
E. Ernst.
Avocado-soybean unsaponifiables (ASU) for osteoarthritis- a systematic review.
Clin Rheumatol, 22 (2003), pp. 285-288
C.V. Little, T. Parsons.
Herbal therapy for treating osteoarthritis.
Cochrane Database Syst Rev, 1 (2001),
K. Walker-Bone.
“Natural remedies” in the treatment of osteoarthritis.
Drugs Aging, 20 (2003), pp. 517-526
M.C. Hochberg, R.D. Altman, K.D. Brandt, B.M. Clark, P.A. Dieppe, M.R. Griffin, et al.
Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology.
Arthritis Rheum, 38 (1995), pp. 1541-1546
G. Papachristou, S. Anagnostou, T. Katsorhis.
The effect of intra-articular hydrocortisone injection on the articular cartilage of rabbits.
Acta Orthop Scand, (1997), pp. 132-134
P. Creamer.
Intra-articular corticosteroid treatment in osteoarthritis.
Curr Opin Rheumatol, 11 (1999), pp. 417-421
J.P. Raynauld, C.H. Buckland-Wright, R. Ward, D. Choquette, B. Haraoui, J. Martel-Pelltier, et al.
Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee. A randomized, double-blind, placebo-controlled trial.
Arthritis Rheum, 48 (2003), pp. 370-377
J.G. Peyron.
Intraarticular hyaluronan injections in the tratment of osteoarthritis: state-of-the art review.
J Rheumatol, 20 (1993), pp. 10-15
Dougados M. Gossec.
Intra-articular treatments in osteoarthritis: from the symptomatic to the structure modifying.
Ann Rheum Dis, 63 (2004), pp. 478-482
I. Pasquali-Ronchetti, D. Guerra, F. Taparelli, F. Boraldi, G. Bergamini, G. Mori, et al.
Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis.
Rheumatology Oxford, 40 (2001), pp. 158-169
G.H. Lo, M. Lavalley, T. MacAlidon, D.T. Felson.
Intraarticular hyaluronic acid in treatment of knee osteoarthritis. A meta-analysis.
JAMA, 290 (2003), pp. 3115-3121
C.T. Whang, J. Lin, C.J. Cang, Y.T. Lin, S.M. Hou.
Therapeutics effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials.
J Bone Joint Surg, 84 (2004), pp. 538-545
M. Wobig, G. Bach, P. Beks, A. Dickut, J. Runzheimer, G. Schwieger, et al.
The role of elastoviscocity in the efficacy of viscosupplemetation for osteoarthritis of the knee: a comparison of hylan G-F 20 and a lower molecular weight hyaluronan.
Clin Ther, 21 (1999), pp. 1549-1562
V. Listrat, X. Ayral, F. Paternella, J.P. Bonvarlet, J. Simonnet, B. Amor, et al.
Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee.
Osteoarthritis Cartilage, 5 (1997), pp. 153-160
R.W. Jubb, S. Piva, L. Beinat, J. Dacre, P. Gishen, on behalf of the UK Hyalgan Study Group.
Structure modification in osteoarthritis with intra- articular sodium Hyaluronate of man. 500-730 KDa.
Ann Rheum Dis, 60 (2001), pp. 46.
J. Arrich, F. Piribauer, P. Mad, D. Schmid, K. Klaushofer, M. Mullner.
Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis.
CMAJ, 172 (2005), pp. 1039-1043
F.J. Blanco-García.
Manual SER de la artrosis. Sociedad Española de Reumatología.
1.ª ed., IM&C, (2002),
Copyright © 2005. Elsevier España S.L. Barcelona
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