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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La artritis psori&#225;sica &#40;AP&#41; es una enfermedad autoinmunitaria&#44; inflamatoria&#44; cr&#243;nica que se caracteriza por artritis y psoriasis cut&#225;nea y se clasifica en el grupo de las espondiloartropat&#237;as &#40;EA&#41;&#46; Su gran heterogeneidad cl&#237;nica ha dificultado el estudio de su patogenia y la realizaci&#243;n de ensayos cl&#237;nicos aleatorizados extensos con DMARD &#40;<span class="elsevierStyleItalic">disease-modifying anti-rheumatic drugs</span> &#91;f&#225;rmacos antirreum&#225;ticos modificadores de la enfermedad&#93;&#41;&#46; La eficacia de las terapias biol&#243;gicas en la AP ha suscitado un gran inter&#233;s en esta enfermedad&#44; en su clasificaci&#243;n cl&#237;nica y en los mecanismos patog&#233;nicos subyacentes&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">A continuaci&#243;n&#44; se revisan varios art&#237;culos recientes sobre la patogenia de la AP&#44; centrados en la angiogenesis sinovial y su potencial como diana terap&#233;utica&#59; en la expresi&#243;n sinovial de macr&#243;fagos y prote&#237;na p53 y su relaci&#243;n con la destrucci&#243;n articular en la arthritis reumatoide &#40;AR&#41; y AP&#46; Finalmente&#44; se analiza si la forma poliarticular de la AP comparte caracter&#237;sticas inmunohistoqu&#237;micas con la AR o con las EA&#46; Aunque la efectividad de las terapias anti-factor de necrosis tumoral &#91;TNF&#93;-&#945; en la AR y la AP apoya que la patogenia de ambas enfermedades es similar&#44; estos y otros estudios indican que existen diferencias en la expresi&#243;n y el significado patog&#233;nico de ciertas c&#233;lulas y mol&#233;culas&#46; De confirmarse&#44; existir&#237;a la posibilidad de desarrollar nuevas terapias espec&#237;ficas para la AP&#46;</p>"
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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Psoriatic arthritis &#40;PsA&#41; is a chronic inflammatory autoimmune disease characterized by arthritis and psoriasis of the skin&#46; It is classified within the spondyloarthropathies &#40;SpA&#41; group&#46; The wide clinical heterogeneity of PsA has hampered research into its pathogenesis and the performance of large randomized clinical trials with disease-modifying anti-rheumatic drugs&#46; The success of biologic agents in PsA has stimulated wide interest in this disease as well as in its clinical classification and underlying pathogenic mechanisms&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">Several recent articles on the pathogenesis of PsA are reviewed&#44; focussing on the potential of synovial angiogenesis as a therapeutic target and on synovial expression of macrophages and p53 protein related to joint damage in rheumatoid arthritis &#40;RA&#41; and PsA&#46; Finally&#44; the question of whether the polyarticular variant of PsA shares immunohistochemical features with RA or SpA is also discussed&#46; Although the success of tumor necrosis factor-alpha antagonists in both RA and PsA supports a similar pathogenesis in both disorders&#44; these and other studies suggest that there are differences in the synovial expression and pathogenic significance of certain cells and molecules&#46; If confirmed&#44; this phenomenon could open new avenues in specific therapy for PsA&#46;</p>"
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                      "titulo" => "Matrix metalloproteinase-9&#44; apoptosis&#44; and vascular morphology in early arthritis"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distinct vascular patterns of early synovitis in psoriatic&#44; reactive and psoriatic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Reece"
                            1 => "J&#46;D&#46; Ca&#241;ete"
                            2 => "W&#46;J&#46; Parson"
                            3 => "P&#46; Emery"
                            4 => "D&#46;J&#46; Veale"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(199907)42:7<1481::AID-ANR23>3.0.CO;2-E"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1999"
                        "volumen" => "42"
                        "paginaInicial" => "1481"
                        "paginaFinal" => "1484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10403277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic usefulness of synovial vascular morphology in chronic arthritis&#46; A systematic survey of 100 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Ca&#241;ete"
                            1 => "J&#46;R&#46; Rodr&#237;guez"
                            2 => "G&#46;S&#46; Salvador"
                            3 => "A&#46; G&#243;mez"
                            4 => "J&#46; Mu&#241;oz-G&#243;mez"
                            5 => "R&#46; Sanmart&#237;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/sarh.2002.50004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "32"
                        "paginaInicial" => "378"
                        "paginaFinal" => "387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12833246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angiopoietins&#44; growth factors&#44; and vascular morphology in early arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Fearon"
                            1 => "K&#46; Griosios"
                            2 => "A&#46; Fraser"
                            3 => "R&#46; Reece"
                            4 => "P&#46; Emery"
                            5 => "P&#46;F&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "260"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12563678"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
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              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Ca&#241;ete"
                            1 => "J&#46;L&#46; Pablos"
                            2 => "R&#46; Sanmart&#237;"
                            3 => "C&#46; Mallofre"
                            4 => "S&#46; Marsal"
                            5 => "J&#46; Maymo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20181"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "paginaInicial" => "1636"
                        "paginaFinal" => "1641"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15146434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Salvador"
                            1 => "R&#46; Sanmart&#237;"
                            2 => "A&#46; Garc&#237;a-Peir&#243;"
                            3 => "J&#46;R&#46; Rodr&#237;guez-Cros"
                            4 => "J&#46; Munoz-G&#243;mez"
                            5 => "J&#46;D&#46; Ca&#241;ete"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2004.024430"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2005"
                        "volumen" => "64"
                        "paginaInicial" => "183"
                        "paginaFinal" => "187"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15647425"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                          "etal" => true
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                            1 => "D&#46; Baeten"
                            2 => "L&#46;D&#46; De Rycke"
                            3 => "B&#46; Vandooren"
                            4 => "D&#46; Foell"
                            5 => "J&#46; Roth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Research &#38; Therapy"
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                        "paginaFinal" => "R580"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25786049"
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Vol. 1. Núm. 4.
Páginas 218-222 (noviembre - diciembre 2005)
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Vol. 1. Núm. 4.
Páginas 218-222 (noviembre - diciembre 2005)
Revisión
Acceso a texto completo
Sinovitis psoriásica: implicaciones patogénicas y terapéuticas
Psoriatic synovitis: pathogenic and therapeutic implications
Visitas
10211
J.D. Cañete-Crespillo
Autor para correspondencia
jcanete@clinic.ub.es

Correspondencia: Dr. J.D. Cañete-Crespillo. Unidad de Artritis. Servicio de Reumatología. Hospital Clínic de Barcelona. Villarroel, 170. 08036 Barcelona. España.
Unidad de Artritis. Servicio de Reumatología. Hospital Clínic de Barcelona. España
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Resumen
Bibliografía
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Estadísticas

La artritis psoriásica (AP) es una enfermedad autoinmunitaria, inflamatoria, crónica que se caracteriza por artritis y psoriasis cutánea y se clasifica en el grupo de las espondiloartropatías (EA). Su gran heterogeneidad clínica ha dificultado el estudio de su patogenia y la realización de ensayos clínicos aleatorizados extensos con DMARD (disease-modifying anti-rheumatic drugs [fármacos antirreumáticos modificadores de la enfermedad]). La eficacia de las terapias biológicas en la AP ha suscitado un gran interés en esta enfermedad, en su clasificación clínica y en los mecanismos patogénicos subyacentes.

A continuación, se revisan varios artículos recientes sobre la patogenia de la AP, centrados en la angiogenesis sinovial y su potencial como diana terapéutica; en la expresión sinovial de macrófagos y proteína p53 y su relación con la destrucción articular en la arthritis reumatoide (AR) y AP. Finalmente, se analiza si la forma poliarticular de la AP comparte características inmunohistoquímicas con la AR o con las EA. Aunque la efectividad de las terapias anti-factor de necrosis tumoral [TNF]-α en la AR y la AP apoya que la patogenia de ambas enfermedades es similar, estos y otros estudios indican que existen diferencias en la expresión y el significado patogénico de ciertas células y moléculas. De confirmarse, existiría la posibilidad de desarrollar nuevas terapias específicas para la AP.

Palabras clave:
Artritis psoriásica
Sinovitis
Patogénesis

Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune disease characterized by arthritis and psoriasis of the skin. It is classified within the spondyloarthropathies (SpA) group. The wide clinical heterogeneity of PsA has hampered research into its pathogenesis and the performance of large randomized clinical trials with disease-modifying anti-rheumatic drugs. The success of biologic agents in PsA has stimulated wide interest in this disease as well as in its clinical classification and underlying pathogenic mechanisms.

Several recent articles on the pathogenesis of PsA are reviewed, focussing on the potential of synovial angiogenesis as a therapeutic target and on synovial expression of macrophages and p53 protein related to joint damage in rheumatoid arthritis (RA) and PsA. Finally, the question of whether the polyarticular variant of PsA shares immunohistochemical features with RA or SpA is also discussed. Although the success of tumor necrosis factor-alpha antagonists in both RA and PsA supports a similar pathogenesis in both disorders, these and other studies suggest that there are differences in the synovial expression and pathogenic significance of certain cells and molecules. If confirmed, this phenomenon could open new avenues in specific therapy for PsA.

Key words:
Psoriatic arthritis
Synovitis
Pathogeny
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Bibliografía
[1.]
D.D. Gladman.
Current concepts in psoriatic arthritis.
Curr Opin Rheumatol, 14 (2002), pp. 361-366
[2.]
D. Veale, O. FitzGerald.
Psoriatic arthritis.
Best Pract Res Clin Rheumatol, 16 (2002), pp. 523-535
[3.]
P.S. Heliwell.
Relationship of psoriatic arthritis with the other spondyloarthropathies.
Curr Op Rheumatol, 16 (2004), pp. 344-349
[4.]
C. Palazzi, I. Olivieri, A. Petricca, et al.
Rheumatoid artritis or psoriatic arthritis symetrical polyarthritis? A difficult differential diagnosis.
J Rheumatol, 20 (2002), pp. 3-4
[5.]
A.P. Anandarajah, C.T. Ritchlin.
Pathogenesis of psoriatic arthritis.
Curr Op Rheumatol, 16 (2004), pp. 338-343
[6.]
D. Baeten, H.J. Moller, J. Delanghe, E.M. Veys, S.K. Moestrup, F. De Keyser.
Association of CD163+ macrophages and local production of soluble CD163 with lower lymphocyte activation in spondyloarthropathy synovitis.
Arthritis Rheum, 50 (2004), pp. 1611-1623
[7.]
C.T. Ritchlin, S.A. Haas-Smith, P. Li, D.G. Hicks, E.M. Schwarz.
Mechanisms of TNFa-and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis.
J Clin Invest, 111 (2003), pp. 821-831
[8.]
H.G. Fassbender.
Pathology and pathobiology of rheumatic diseases.
2nd ed., Springer, (2002),
[9.]
D. McGonagle, P.G. Conaghan, P. Emery.
Psoriatic arthritis: a unified concept twenty years on.
[10.]
A. Fraser, U. Fearon, R. Reece, P. Emery, D.J. Veale.
Matrix metalloproteinase-9, apoptosis, and vascular morphology in early arthritis.
[11.]
R. Reece, J.D. Cañete, W.J. Parson, P. Emery, D.J. Veale.
Distinct vascular patterns of early synovitis in psoriatic, reactive and psoriatic arthritis.
[12.]
J.D. Cañete, J.R. Rodríguez, G.S. Salvador, A. Gómez, J. Muñoz-Gómez, R. Sanmartí.
Diagnostic usefulness of synovial vascular morphology in chronic arthritis. A systematic survey of 100 cases.
Semin Arthritis Rheum, 32 (2003), pp. 378-387
[13.]
U. Fearon, K. Griosios, A. Fraser, R. Reece, P. Emery, P.F. Jones, et al.
Angiopoietins, growth factors, and vascular morphology in early arthritis.
J Rheumatol, 30 (2003), pp. 260-268
[14.]
J.D. Cañete, J.L. Pablos, R. Sanmartí, C. Mallofre, S. Marsal, J. Maymo, et al.
Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritis.
Arthritis Rheum, 50 (2004), pp. 1636-1641
[15.]
G. Salvador, R. Sanmartí, A. García-Peiró, J.R. Rodríguez-Cros, J. Munoz-Gómez, J.D. Cañete.
p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage.
Ann Rheum Dis, 64 (2005), pp. 183-187
[16.]
E. Kruithof, D. Baeten, L.D. De Rycke, B. Vandooren, D. Foell, J. Roth, et al.
Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis.
Arthritis Research & Therapy, 7 (2005), pp. R569-R580
Copyright © 2005. Elsevier España S.L. Barcelona
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