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DOI: 10.1016/j.reumae.2021.01.001
Available online 3 June 2021
Relationship of IP-10 gene expression to systemic lupus erythematosus activity
Relación de la expresión génica de IP-10 con la actividad del lupus eritematoso sistémico
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Julián Torres-Vázqueza, Martín Uriel Vázquez-Medinaa,b,c,
Corresponding author
marvazcan65@hotmail.com

Corresponding author.
, David Alberto Comoto-Santacruzd, Mariano Emilio Pradillo-Maciasa,c, Omar Eloy Muñoz-Monroya, Adriana Martínez-Cuazitla,c,d
a Hospital Central Militar, SEDENA, Mexico City, Mexico
b Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico
c Departamento de Investigación, Hospital Central Militar, SEDENA, Mexico City, Mexico
d Laboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, SEDENA, Mexico City, Mexico
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Table 1. Characteristics of the groups and relative gene expression (fold change) of IP-10.
Abstract
Objectives

To evaluate IP-10 gene expression in patients with SLE, and its possible relationship with disease activity.

Patients and methods

This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the level of lupus activity evaluated with the SLEDAI 2-K instrument.

Results

Different levels of gene expression were found according to the SLE activity (P = <.001). IP-10 gene expression levels were higher in patients with severe activity than in those with no activity, low activity, and moderate activity. The increase in gene expression in the severe activity group was significant with a Fold Change of 3

Conclusion

The significant increase in relative gene expression IP-10 may be a marker of severe lupus activity.

Keywords:
CXCL-10
IP-10
INF
SLE
Systemic lupus erythematosus
Lupus activity
Resumen
Objetivo

Evaluar la expresión génica del gen IP-10 en pacientes con LES, y su posible relación con la actividad de la enfermedad.

Pacientes y métodos

El estudio incluyó 120 pacientes diagnosticados con LES y 30 controles sanos. Se investigó la expresión génica relativa de IP-10 con el método Fold Change, la cual fue correlacionada con el nivel de actividad lúpica evaluado con el instrumento SLEDAI 2-K.

Resultados

Se encontró diferentes niveles en la expresión génica de IP-10 relacionada con la actividad lúpica (p= <0,001). Los niveles de expresión génica de IP-10 fueron mayores en los pacientes con actividad grave respecto a aquellos sin actividad, actividad baja y actividad moderada. El incremento en la expresión génica del grupo con actividad grave fue significativo con un Fold Change de 3.

Conclusión

El incremento significativo en la expresión génica relativa IP-10 puede ser un marcador de actividad lúpica grave.

Palabras clave:
CXCL-10
IP-10
INF
LES
Lupus eritematoso sistémico
Actividad lúpica

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